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If you are a victim of digoxin poisoning, you will be prescribed the digoxin toxicity antidote. but what is digoxin? Digoxin is a medication commonly prescribed to treat heart conditions like congestive heart failure and atrial fibrillation (such as angina). While it can be highly effective in managing these conditions for you, the therapeutic window for digoxin is narrow, and if you overdose on it, it will lead to digoxin toxicity, a potentially life-threatening condition.