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Angiotensin II receptor blocker (ARB) drugs, also referred to as angiotensin receptor blockers or angiotensin receptor antagonists, constitute a vital class of medications used in the management of various cardiovascular and renal conditions. These medications play a pivotal role in the treatment of hypertension, heart failure, kidney diseases, and angina by targeting the renin-angiotensin-aldosterone system (RAAS). Here, I will explore the mechanisms of ARB drugs, their medical applications, potential side effects, and the importance of consulting a healthcare professional before commencing any treatment, with a particular focus on their role in addressing angina and chest pain.