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Modulator therapies, manufactured by Vertex Pharmaceuticals (VRTX.O), may no longer be available for new cystic fibrosis (CF) patients in the UK. A draft guidance recently published by the National Institute for Health and Care Excellence (NICE) stated that it would not recommend the use of Kaftrio, Symkevi and Orkambi on new CF patients. Kaftrio and Symkevi are currently recommended for the treatment of cystic fibrosis in patients aged 6 years and older, while Orkambi is used for patients aged 1 and older. The NICE draft guidance highlighted medicine costs and the strain on resources and finances faced by the National Health Service (NHS) as reasons for removing these drugs.

311: Idiopathic Pulmonary Fibrosis (N) is organized by Medical Education Systems (MedEdSys), Inc. Identify how idiopathic pulmonary Fibrosis is diagnosed

Wear purple customized silicone wristbands to support cystic fibrosis and to raise awareness on the same.

Know the causes, diagnosis and treatments for cystic fibrosis and support awareness with custom silicone wristbands.

The outbreak of Burkholderia cepacia complex (Bcc) in the UK, which is associated with contaminated eye gels imported from India, has led to the death of one person, and many others falling ill, according to a government report. Bcc is a group of antibiotic-resistant bacteria that are widely found within the environment. Although it rarely causes infection, it can result in severe ones in individuals with compromised immune systems and those living with cystic fibrosis, the UK Health Security Agency (UKHSA) said. Between January 2023 and February 2024, there were 52 confirmed and six probable cases across the UK linked to the bacteria outbreak, as revealed in the Health Protection Report published by UKHSA. Forty-one of these cases were hospital inpatients, 38 of which were in critical-care settings. Twenty-five cases were considered to have "clinically significant infections attributable to Bcc", out of which 11 had eye infections, nine had respiratory infections and four had bacteremia (bacteria entering the bloodstream). Two individuals with cystic fibrosis (CF) were infected, and while one was treated, the other died, with the report indicating Bcc infection to have "contributed to the death."

New drug targets a faulty protein that causes cystic fibrosis led to improved lung function, fewer symptoms in people with the lung disease.

Pharmacy professionals to be included as key stakeholders in the implementation, delivery and evaluation of a wide range of genomic services, said the Royal Pharmaceutical Society (RPS). RPS's statement has been developed in collaboration with pharmacy organisations who have co-badged the report, such as the British Oncology Pharmacy Association, the UK Clinical Pharmacy Association, Association of Pharmacy Technicians and the College of Mental Health Pharmacy. It looks at current and future roles for pharmacy professionals in genomic medicine across many aspects of practice such as person-centred care and collaboration, professional practice, education, leadership, management and research. Pharmacists and pharmacy technicians in the UK have already established roles in the application of genomic medicine in some areas of practice, such as antimicrobial stewardship and infectious diseases, and the management of certain genetic conditions, such as cystic fibrosis. The society believes, the current role of pharmacy professionals in genomics can be expanded upon in the future to both lead and support many relevant aspects of genomic implementation. These are described across all healthcare sectors, within the Genome UK strategy produced by the UK Government, and within the implementation plans published in England, Scotland and Wales. Lead for Pharmacogenomics at RPS Sophie Harding said: "Pharmacy professionals are the gatekeepers of medication safety and efficacy across all areas of healthcare. They are skilled at interpreting complex scientific data and use evidence-based medicine to maximise the benefits of treatments for patients, whilst supporting shared decision-making with patients and the multidisciplinary team.

Non-alcoholic fatty liver disease (NAFLD) is a common liver condition that requires timely diagnosis. It involves a spectrum of liver conditions ranging from non-alcoholic steatohepatitis (NASH) to fibrosis and can eventually evolve into cirrhosis. Over the years, liver biopsy has been the popular diagnostic procedure for NASH/NAFLD. However, considering the progressive nature of NAFLD, sole reliance on liver biopsy procedures does not only lack feasibility but is also susceptible to suboptimal standardization. Going through liver biopsy surgery is unnecessary at the slightest observation of NAFLD symptoms. Observing NASH/NAFLD red flags is not enough to determine the presence of the disease. You will need a proper diagnosis to ascertain the liver condition. This article emphasizes the benefits of choosing the non-invasive liver test diagnostic procedure instead of the invasive method. UNDERSTANDING NASH/NAFLD Nonalcoholic Fatty Liver Disease (NAFLD) is one of two types: simple fatty liver or NAFL and Non-Alcoholic Steatohepatitis (NASH). Simple fatty liver or NAFL indicates the presence of fat in the liver. NASH is the least common and clinically aggressive variant of NAFLD.

In partnership with the Prescription Charges Coalition (PCC), the Royal Pharmaceutical Society (RPS) has taken a significant step by urging political leaders to abolish prescription charges for individuals with long-term conditions. Tase Oputu, Chair of the RPS England Pharmacy Board, signed an open letter on Thursday, calling on party leaders to address this pressing issue. The letter emphasises the outdated nature of the current exemption list, which forces individuals with chronic conditions like Parkinson's, cystic fibrosis, and HIV to bear the cost of their essential medications. It urges party leaders to urgently review and update the exemption list to ensure equitable access to necessary medicines. "Nobody should face a financial barrier to accessing the medicines they need," Oputu stated.

The current funding and contractual framework for community pharmacy is not fit for purpose, the Health and Social Care Committee report has concluded, recommending a complete overhaul to reduce its complexity. Published today, the report highlighted the necessity for a new framework to ensure adequate funding and to prevent damaging cross-subsidy between clinical services and prescription dispensing, as is presently observed. The report revealed that community pharmacy funding has fallen by over 30 per cent in real terms since 2015, resulting in an annual shortfall of at least £67,000 per pharmacy for individual owners. More than 1,100 community pharmacies have closed since 2015, of which were serving the most deprived areas, it said. MPs on the committee have urged the government to address medicine shortages, warning that they could undermine flagship initiatives such as 'Pharmacy First' by eroding public confidence in pharmacists. "People living with type 2 diabetes, ADHD, epilepsy and cystic fibrosis, and those experiencing the menopause, have faced challenges accessing the vital medication they need. Many others are facing similar experiences.

Chronic hepatitis due to viral infection causes liver cell damage leading to fibrosis or even cirrhosis, impairing the liver's ability to function properly. A few patients are advised for liver transplant which is not a simple operation. Mynahcare talked to two eminent doctors on liver transplantation and its intricacies.

PBR Staff Writer Published 24 February 2014 US-based biotechnology firm Vertex Pharmaceuticals has received approval from the US Food and Drug Administration (FDA) for a supplemental New Drug Application (sNDA) of its Kalydeco (ivacaftor) for the treatment of people with cystic fibrosis (CF).