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An experimental Alzheimer's drug developed by Eli Lilly and Co slowed cognitive decline by 35% in a late-stage trial, the company said on Wednesday, providing what experts say is the strongest evidence yet that removing sticky amyloid plaques from the brain benefits patients with the fatal disease. Lilly's drug, donanemab, met all goals of the trial, the company said. It slowed progression of Alzheimer's by 35% compared to a placebo in 1,182 people with early-stage disease whose brains had deposits of two key Alzheimer's proteins, beta amyloid as well as intermediate levels of tau, a protein linked with disease progression and brain cell death. The study also evaluated the drug in 552 patients with high levels of tau and found that when both groups were combined, donanemab slowed progression by 29% based on a commonly used scale of dementia progression known as the Clinical Dementia Rating Scale (CDR-SB). Using that scale, experts said Lilly's findings were roughly on par with Eisai Co Ltd and Biogen Inc's lecanemab, sold under the brand name Leqembi, which reduced cognitive decline by 27% in patients with early Alzheimer's in a study published last year. The results drove Lilly's shares to a record high, up more than 6% at $429.85. Dr. Ronald Petersen, an Alzheimer's researcher at Mayo Clinic, said Lilly's trial is the third to show removing amyloid from the brain slows progression of the disease, which could put to rest some lingering doubts about the benefits of drugs in the class and the amyloid-lowering theory. "It's modest, but I think it's real," he said of the benefit, "and I think it's clinically meaningful." Dr. Erik Musiek, a Washington University neurologist at Barnes-Jewish Hospital, said the efficacy looks as good or better than lecanemab.

A study by scientists in a UK university has shown the scale of the prevalence of a condition that can lead to various cardiometabolic diseases. The study published in the Annals of Internal Medicine journal on Tuesday (January 4) has prompted calls for changes to healthcare policy after researchers revealed, for the first time, the scale of the impact of the condition associated with benign tumours that can lead to type 2 diabetes and high blood pressure. Up to 10 per cent of adults have a benign tumour, or lump, known as an 'adrenal incidentaloma' in their adrenal glands which can be associated with the overproduction of hormones including the stress steroid hormone cortisol that can lead to type 2 diabetes and high blood pressure. Previous small studies suggested that one in three adrenal incidentalomas produce excess cortisol, a condition called mild autonomous cortisol secretion (MACS). An international research team led by the University of Birmingham carried out the largest ever prospective study of over 1,305 patients with adrenal incidentalomas to assess their risk of high blood pressure and type 2 diabetes and their cortisol production by comparing patients with and without MACS.

The National Pharmacy Association (NPA) has called on the NHS and the Department of Health to immediately publish the government-commissioned analysis of pharmacy underfunding and reveal the true scale of the crisis. Commissioned by NHS England, the long-awaited independent review is expected to "lay bare the perilous financial state" of community pharmacies, which is a vital part of the nation's health infrastructure. However, the NPA is concerned that the government may delay its release until after current funding consultations are concluded. The NPA argued that the public needs to understand the fragile nature of the pharmacy network before any new deal can be agreed. It has also warned health officials not to hide "the true scale of funding needed to reverse a decade of swingeing cuts", which has forced record numbers of pharmacy closures. NPA chair Nick Kaye said: "It would be a scandal to keep that evidence buried secret and leave MPs, pharmacies and the public in the dark." He acknowledged that the new government has inherited a crisis in pharmacy funding and emphasised that it will need to take "strong action" to maintain access to medicines.

The Department of Health and Social Care (DHSC) has introduced new arrangements for the application of discount deduction to community pharmacy payments which will be implemented in six financial quarters beginning in October 2022 and concluding in January 2024. Under the new discount deduction system, the current single scale will be split into three groups: one each for generic medicines, branded medicines, and appliances. Separate fixed deduction rates have been determined for each group. This will provide all pharmacies the same rates of deduction applied to their reimbursement for the three different groups, regardless of the total value of that reimbursement. Fin McCaul, PSNC member and independent community pharmacy contractor, said: "The discount deduction scale has been a point of contention for contractors for many years, and PSNC has long been pushing to remedy this. "The incoming changes are designed to both improve equity of access to margin and manage the distortions presented by branded medicines, which just don't have the same level of discount available as generics.

The pharmacy market in England has seen a significant transformation in recent years, driven by a trend of large-scale disposals by corporate operators. Jonathan Board, Director - Pharmacy, Christie & Co, has told Pharmacy Business that several corporate operators are looking to sell off their marginal or non-performing assets while independent operators are eager to acquire and enhance businesses further. Due to their scale, corporate operators are compelled to adopt a 'one size fits all' approach. However, Jonathan believes this puts them at a disadvantage compared to many independent operators who are better positioned to meet local patient and community needs, delivering a more personalised approach to patient engagement, and a variety of other services "As such, where corporate disposals have taken place, there has been a steady stream of independent operators eager to take over and develop the businesses further," he said.

My Sweat Life blogger Kelsey Wells has proved that weight on a scale is insignificant when it comes to being fit and healthy. She has urged her fans - all (almost) half a million of them - to 'Screw the Scale'. Read the complete post here and learn how she has challenged perceptions of weight with a set of photos.

"There are many different kinds of safety factors that should be adhered to when you are exercising. For instance, it is essential to warm up beforehand and warm down afterwards to prevent muscle and tendon strain and injury. It is also wise to start your exercise regime at the low end of the scale and build up gradually over some weeks, so you don't strain muscles that are weak. However, there are less obvious considerations that are often forgotten when you go off to your exercise class."

"There are many different kinds of safety factors that should be adhered to when you are exercising. For instance, it is essential to warm up beforehand and warm down afterwards to prevent muscle and tendon strain and injury. It is also wise to start your exercise regime at the low end of the scale and build up gradually over some weeks, so you don't strain muscles that are weak. However, there are less obvious considerations that are often forgotten when you go off to your exercise class."

Dr Michael Gamlen, the inventor of Gamlen instruments presents a tablet press machine to the students at the School of Pharmacy on 16 October. The equipment not only solves the challenge of producing lab-scale tablets under precise conditions but also offers valuable insights into material compaction properties. It is also known as a powder compaction analyser which has been given on loan to the University of Sunderland for five years. Dr Gamlen talks about the machine and how pharmacy students will benefit, saying: "It allows you to make tablets under tightly controlled conditions and enables you to make accurate comparisons between different materials and processes. "The students will be able to easily see the impact of the tablet compaction conditions on tablet properties. This is very important to understand when developing new tablet formulations and manufacturing products."

Tricycle is also better and will enable the rider to make sharper turns on roads. Every time a person needs to be seated in a conventional tricycle or disembark from it, the needs help. But attached footrests to help the rider. With a bigger seat and stronger tyres, the vehicle will also help vendors. And every part of the cycle can be dismantled too, which makes it easier to transport. Although tricycles are often associated with toddlers, they are also widely ridden by adults. 'Trikes' are often ridden by older adults or people with disabilities who prefer the extra balance offered by a third wheel. Characteristics of Tricycles: Three wheels. Easily balanced. Brakes. Gears. Often have a storage basket at the rear. Can buy electric powered tricycles. In tricycles distinct types of pedal-driven motion. The tricycle was conceived and produced especially for children from the outset, however bicycles for children were derived by a simple reduction of the scale of the adult counterpart. Standard Single Hand Drive Tricycle: Frame : Made by E.R.W. Tubes 22.22 mm- 18 G. Seat & Back : MS, CRC Sheet Seat Size 18"x 16" Wheel Size : Wheel Diameter 28"x 1 1/2" Tyre and Tube Standard Company. Parts : Standard Quality Color : Black Painted Brake : Front Wheel liver System Drive : Rear Wheel Right Side Tricycle with rear wheel chain-driven transmission and a diamond shaped frame, it quickly entered into widespread use for transportation, work, and leisure purposes. Tricycles are available to accommodate a vast array of special needs. Hand-pedaled recumbent tricycles make it possible for those without the use of their legs. Children, teens and adults with cerebral palsy and similar disorders can select tricycles specially designed to increase strength and coordination. Caregivers to autistic children can ride with their child on tandem special needs tricycles built to accommodate one adult and one child rider.

Travel Wheelchair is also known as Transport Wheelchair or ultra lightweight aluminium wheelchair. Travel wheelchair are great for road trips or travel tours, you can go anywhere with a Travel chair, the frame is so light and easy to fold and store, this type of wheelchair fits easily into the trunk of your car or if you are traveling by plane, bus or train. Travel Wheelchair are easy to carry and fold it is so ultra lightweight that can be folded into small bag for easy transportation and storage. Travel wheelchair utilizing small caster wheel and lightweight materials and can tip the scale at as little as 14.5 kg. Travel chairs are geared towards storability and portability but they are even more convenient for those on-the-go. Travel Wheelchair feature four smaller wheels, rather than the large rear-mounted wheels that characterize standard wheelchairs and their design ensures that they are always foldable and convenient to carry, whether it's a family vacation, or a good fashioned road trip, Travel wheelchair are best. Travel wheelchair is a lightweight Folding Wheelchairs with manual drive having compact size, easy to carry with its foldable nature. Travel wheelchair is ideal for both outdoor and indoor usage and mostly used while travelling and it has a fold-down back and swing-away footrests for easy storage and transport. Transport Wheelchair features comfortable padded arm rests, adjustable seatbelt and a cup holder in a convenient location for the user. Seat Widths and Depths- Most models of wheelchair in the Ultra Lightweight Wheelchairs category offer standard sizes from 12" to 20" in 1" increments a some will even allow for custom orders for in between sizes of seat width. Seat Heights- Seat to floor heights of this category can be anywhere from 14" to 22" and will often be up to 2" lower at the back of the seat to create what is known as "dump". Armrests- Armrests on Travel wheelchair depending on the model and can be exactly the sa

The portable travel wheelchairs, utilizing small caster wheel and lightweight materials, can tip the scale at as little as 13 lbs! Like our transport chairs, travel chairs are geared towards storability and portability, but they're even more convenient for those on-the-go. These chairs feature four smaller wheels, rather than the large rear-mounted wheels that characterize standard wheelchairs, and their design ensures that they're always foldable and convenient to carry. Whether it's a family vacation, or a good fashioned road trip, these lightweight wheelchairs are your best bet. There are a new breed of ultra lightweight aluminium wheelchairs available that fold down for easy transportation and storage. These compact travel folding wheelchairs fit neatly into the boot of a car and are ideal for use on holiday, for days out or for short shopping trips.The Light Travel Wheelchair in a Holdall is an ultra lightweight aluminium wheelchairs which fold into its own bag for easy transportation and storage. Every vacation is an opportunity to experience the adventure of a lifetime. And with the right wheelchair, nothing will stand in your way. A portable wheelchair gives you the freedom to travel anywhere and everywhere with ease. Whether you're on a family road trip, a dream vacation to Disneyland, or a Caribbean cruise, a travel wheelchair can make all the difference. No matter where you are going, you'll want to make sure your travel wheelchair is: Lightweight: A lightweight wheelchair lets you keep up with the group and lifts into cars, buses or other transportation easily. Compact: To avoid hassles, your compact wheelchair should easily fold up at the door of an airplane, easy lift into the overhead compartment, or to fit into the trunk of an automobile. Durable: When traveling, you don't want to get stuck because your wheelchair broke down or you have a flat tire. Adaptable: You won't want to miss out on eating at a special res

Tricycle FOr Disabled People People with disabilities have often been excluded from mobility and access opportunities. Certainly, our public transport system has some way to go before it is even close to being accessible to everyone. With cycling for people with disabilities becoming one of the fastest-growing areas of interest in the cycling world, it is likely that cycling with its versatile simplicity and low running costs will succeed in providing access where other forms of transport have failed. Small-scale manufacturers are combining innovation with positive attitude and designing cycles that meet abilities. "Most of the people who depend on these tricycles are daily wage workers who have to travel long distances every day. The regular tricycles have no suspension and the riders are prone to spinal injuries. Most of them also cannot afford good medical care, and driving these tricycles for a long time affects their back," he added. We have several bicycles for people who have a problem with cycling. We produce special bicycles, tricycles, tricycles for children, adult tricycles, tandems, side by side bikes, wheelchair bikes, wheelchair transport bikes, a walking aid and a bicycle for the transport of 8 children. Benefits Lower extremity strengthening Reciprocal leg motion patterning Balancing skills Using visual, spatial perception for steering Social interaction with peers and neighbors Specifications 1.good quality and useful tricycle 2.for reasonable price Tricycle FOr Handicapped Children The most important requirements were: Stability The stability of the tricycle is very important for the safety of the user. This can be achieved by making the wheelbase wide enough and the center of gravity as low as possible but limited by the space needed for the legs of the user. Driving comfort The correct position of the propulsion handles is necessary for easy and comfortable driving. Weight Many existing tr

Utilizing small wheels and lighter materials, transport wheelchairs can tip the scale at as little as 19 lbs., ideal for those looking for a highly portable option. Transport chairs also tend to be more affordable and offer the benefit of increased mobility without breaking the bank. This type of lightweight wheelchair is often referred to as a "transfer chair" and is typically used for shorter trips. Since it's geared towards storability and portability, it features four smaller wheels and dispenses with the larger, rear-mounted wheels that characterize standard wheelchairs. Its construction ensures that it's always foldable and portable, but does so at the expense of self-propulsion. Instead, a transport chair is built so that a caregiver can easily push the user from point A to B. Transport Wheelchair features a lightweight aluminum frame with a multiple finish options. It comes standard with padded-permanent armrests and swing-away footrests with composite footplates. It is an ideal solution for easy transportation and storage. Karma KM 2500 Small Wheel Wheelchair: Karma KM 2500 Small Wheel Wheelchair Specifications: Width 18" Front/Rear Wheels 6" to 14" Seat Width 47cm Seat Depth 40cm Overall Width 66cm Overall Collapsed Width 36cm Armrest Height 21cm Overall Length 90cm Seat Height 47cm Backrest Height 38cm Overall Height 86cm Weight 9.2 k.g. Karma KM 2500 Small Wheel Wheelchair Seat and Back: AEGIS Microbe Shield Approved by the FDA, EPA, EU, etc., bonded anti-microbial barrier upholstery protects from odor, staining and deterioration from bacteria, fungus and other microorganisms. It is a shield for your health. Karma KM 2500 Small Wheel Wheelchair Extended Armrest: By simulating the natural position of arms, the extended armrest design is ergonomic and creates bigger seating space. An Ultra lightweight wheelchair (9.2 kg) with a compact design for either attendant assisted or self propelling users. The

Wolf Shlagman is the CEO, Founder, and Chief Angel of Care Angel. He is a creative technologist, tinkerer, and visionary behind the success of the company.

A large-scale European trial has indicated that frozen embryo transfers fail to deliver any improvement over fresh transfers during the in vitro fertilisation (IVF) process.

Face masks can be quite discomforting to wear and there are a lot of reasons not to like them. You have to fiddle with the loops to wear them and after extended wear, they hurt. They also irritate your skin and fog up your glasses and make communication a little difficult. To foster mask adoption, the Department of Health and Human Services (HHS) in collaboration with the National Institute for Occupational Safety and Health (NIOSH) and the Biomedical Advanced Research and Development Authority, has launched a $500,000 "Mask Innovation Challenge" inviting Americans to submit ideas to make masks more comfortable to wear. The content is open until April 21 and participants have until then to submit innovative ideas that eliminate concerns with wearing masks while ensuring they are protecting themselves against coronavirus. In a press statement announcing the contest, Nikki Bratcher-Bowman, the acting assistant secretary for preparedness and response, said "with this mask challenge, we want to get people across the country involved in developing new masks that are both effective and comfortable. This will help us control COVID-19 and be better prepared for future public health emergencies." Contest Requirements and Prizes Anyone with a unique idea that follows CDC safety guidelines can submit their idea on or before 5 p.m ET on April 21. There are other requirements to enter and win this contest: 1. To receive a price, you must be a US citizen or a legal resident 2. For the first phase of the challenge, up to 10 winners will be chosen who will split a $100,000 prize, with each person taking $10,000 home. 3. Several parameters such as filtration efficiency, inhalation airflow resistance, fit, and other test methods will be used to judge the best design. According to HHS, sprays or drugs that can be inhaled or absorbed through the nose, mouth, or skin are not permitted to be used in mask design. NIOSH-approved respirators or FDA-approved surgical masks m

The peak in the number of deaths that stem from heart diseases, is on an increasing scale, every single year. According to research, blood pressure, obesity, inactivity, and high cholesterol levels are contributors to cardiovascular diseases. A sedentary… Read More »