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National Institute of Health and Care Excellence (NICE) has not recommended 'Tirzepatide', also known as Mounjaro, developed by Eli Lilly, in its draft guidance issued on Tuesday (27 June) for treating type 2 diabetes in adults alongside diet and exercise. The independent NICE committee recognised the importance of new treatment options given that fewer than two-thirds of the adults with type 2 diabetes have adequate glucose control when using current treatment options. Evidence submitted to the committee from clinical trials showed the use of tirzepatide at any dose resulted in better glucose control and lower weight compared with semaglutide or insulin therapy. The weight reduction was more pronounced with higher doses of tirzepatide, while the effect on glucose levels seemed less dose-dependent. Similar effects were observed against all GLP-1 receptor agonists in company's network meta-analysis, but this was uncertain. The committee have asked the company to provide more data to address the uncertainties in the clinical evidence, when compared to all relevant alternative treatments.

WAGMI or 'we are all gonna make it' is an established abbreviation in the crypto world, and pharmacists can learn from it. To all the dreamers, the visionaries, the go-getters, the futurists - we need you all. In the past few months, since the rebranding of Facebook into Meta, the word 'Metaverse' has become exponentially popular and there is a huge opportunity for pharmacists to get involved. In his popular podcast, Aragorn Meulendijks, the chief marketing officer at Your Open Metaverse - YOM, gave a crystal-clear vision on the unique and valuable possibility of a metaverse pharmacy or metapharmacy. Imagine it is 2030, and there are over a billion users of Virtual Reality headsets. You have recently been hired as the new metaverse pharmacist (metapharmacist) at the global metaverse pharmacy (metapharmacy) "YOMRx". Your patient comes to your metapharmacy with their digital twin (different to digital avatar)where you are able to provide them with medical advice (metaconsultation).