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Face masks can be quite discomforting to wear and there are a lot of reasons not to like them. You have to fiddle with the loops to wear them and after extended wear, they hurt. They also irritate your skin and fog up your glasses and make communication a little difficult. To foster mask adoption, the Department of Health and Human Services (HHS) in collaboration with the National Institute for Occupational Safety and Health (NIOSH) and the Biomedical Advanced Research and Development Authority, has launched a $500,000 "Mask Innovation Challenge" inviting Americans to submit ideas to make masks more comfortable to wear. The content is open until April 21 and participants have until then to submit innovative ideas that eliminate concerns with wearing masks while ensuring they are protecting themselves against coronavirus. In a press statement announcing the contest, Nikki Bratcher-Bowman, the acting assistant secretary for preparedness and response, said "with this mask challenge, we want to get people across the country involved in developing new masks that are both effective and comfortable. This will help us control COVID-19 and be better prepared for future public health emergencies." Contest Requirements and Prizes Anyone with a unique idea that follows CDC safety guidelines can submit their idea on or before 5 p.m ET on April 21. There are other requirements to enter and win this contest: 1. To receive a price, you must be a US citizen or a legal resident 2. For the first phase of the challenge, up to 10 winners will be chosen who will split a $100,000 prize, with each person taking $10,000 home. 3. Several parameters such as filtration efficiency, inhalation airflow resistance, fit, and other test methods will be used to judge the best design. According to HHS, sprays or drugs that can be inhaled or absorbed through the nose, mouth, or skin are not permitted to be used in mask design. NIOSH-approved respirators or FDA-approved surgical masks m

Oxford Cannabinoid Technologies Holdings plc, which specialises in developing cannabis-derived medicines with pain-relieving properties, has successfully administered the first-in-human dose of its lead pharmaceutical drug compound, OCT461201, in its phase 1 clinical trial. The company holds a portfolio of four drug candidates intended for use as licensed pain medications. The drug is a selective cannabinoid receptor type 2 agonist with the potential to treat chemotherapy-induced peripheral neuropathy and irritable bowel syndrome. The UK trial, conducted by Simbec Research Limited, part of Simbec-Orion Group Ltd., is progressing with healthy volunteers, OCTP said in a statement. Using a single ascending dose protocol, the primary objective is to demonstrate OCT461201's safety and tolerability, while providing information on its pharmacokinetic profile, to confirm its value as a potential drug. Results from the trial, funded entirely by OCTP's existing resources, are expected in the third quarter of 2023, the statement added.

A Tricycle is a type of human-powered land vehicle powered by the arms rather than the legs, as on a bicycle. Most handcycles are tricycle in form, with two coasting rear wheels and one steerable powered front wheel. Despite usually having three wheels, they are also known as handbikes. Many manufacturers have designed and released hand-powered recumbent trikes, or handcycles. Handcycles are a regular sight at HPV meets and are beginning to be seen on the streets. These usually follow a delta design with front wheels driven by standard derailleur gearing powered by hand cranks. Brake levers are usually mounted on the handholds which are usually mounted in phase, unlike pedal cranks, which are usually 180° out of phase. This allows the rider to more easily use their torso to help propel the cycle. The entire crank assembly and the front wheel turn together, allowing the rider to steer and crank simultaneously. Single-Hand-Drive-Tricycle come in a variety of styles, making them accessible to people with a wide variety of disabilities. There are also hybrids between a handcycle, a recumbent bike and a tricycle. Fork steer handcycles represent the majority of handcycles sold. They work well for both low and high-level spinal injuries, and most have adjustable footrests, seat angle, and come with a variety of gearing, wheel and tire configurations depending on intended use: racing, recreation, or touring. Manufacturers of this type of handcycle include Invacare (Top End), Intrepid Equipment, Varna, Schmicking and Sunrise Medical. Lean steer handcycles are another type of handcycle. In this type of handcycle the rider leans into the turn to steer. There is a longer learning curve with lean steer handcycles, and they are significantly less stable at high speed. The lean steer system feels similar to mono skiing: using your whole body to steer the handcycle. Lean steer handcycles can work well for lower-level injuries; although, some athletes with high-level di

Dr. Steven Quay, President and CEO of Atossa Therapeutics, wants us to understand what he calls three phases of COVID-19. He says the first two phases can usually be treated at home, but the third means a trip to the hospital. The goal is to treat the first two phases at home to prevent your body from slipping into the third phase.

Denmark's Zealand Pharma and Boehringer Ingelheim said their experimental obesity treatment achieved up to 14.9% weight loss in a mid-stage trial, lining up a potential contestant in the booming obesity drug market. In a statement on Wednesday (May 10), the partners said that the Phase II dose-finding trial met its primary endpoint of weight loss after 46 weeks. Paola Casarosa, head of therapeutic areas at Germany's Boehringer Ingelheim told Reuters the partners are in discussion with regulators about the design of a planned follow-up trial in the third and last phase of testing. The enormous demand for weight-loss treatments such as Novo Nordisk's Wegovy, or potentially Eli Lilly's Mounjaro, could support as many as 10 competing products with annual sales reaching up to $100 billion within a decade, mostly in the United States, industry executives and analysts said. Lilly said about a year ago that Mounjaro was shown to reduce up to 22.5% in weight after 72 weeks of treatment in a much larger late-stage trial.

Initial weeks are very hectic for the newborns and their mothers, because in this phase, infants are trying to adapt the new things from the surrounding.

Initial weeks are very hectic for the newborns and their mothers, because in this phase, infants are trying to adapt the new things from the surrounding.

The Scottish Medicines Consortium (SMC) has accepted AbbVie's RINVOQ (upadacitinib) for use within NHS Scotland for the treatment of adult patients with moderately to severely active ulcerative colitis (UC). Upadacitinib offers an additional treatment choice in the therapeutic class of janus kinase inhibitors. "Daily life with ulcerative colitis is difficult due to the debilitating and unpredictable nature of its symptoms", said Dr Jonathan Macdonald, Consultant Gastroenterologist at NHS Greater Glasgow and Clyde. "Clinical trials have shown that upadacitinib as a once daily pill controls symptoms in eight weeks for many patients and provided sustained responses at one year. The SMC's decision is good news for people with ulcerative colitis in Scotland as it provides an additional treatment option to help them gain control of their condition." The SMC decision is based on data from the induction studies U-ACHIEVE and U-ACCOMPLISH, as well as the Phase 3 U-ACHIEVE maintenance study, which demonstrated the efficacy of upadacitinib versus placebo in its ability to achieve clinical remission. The SMC's decision follows the granting of Marketing Authorisation for upadacitinib in UC in July 2022.

The US Food and Drug Administration (FDA) has approved the Novartis drug, Cosentyx, (secukinumab) to treat moderate to severe hidradenitis suppurativa (HS) in adults. HS is a chronic, progressive and painful disease which affects one in 100 people worldwide, and has limited treatment options. "Cosentyx is the only FDA-approved fully human biologic that directly inhibits interleukin-17A (IL-17A), a cytokine believed to be involved in the inflammation of HS," said the Swiss company. The FDA approval was based on robust Phase III data (SUNSHINE and SUNRISE studies) in which Cosentyx showed rapid relief from HS symptoms as early as Week 21.

GlaxoSmithKline and Sanofi said on Wednesday (December 15) they expect data from late-stage clinical trials of its booster dose of their Covid-19 vaccine candidate in the first quarter, instead of this year, another delay for the potential shot. The news came as two companies said preliminary data from trials showed the single-dose booster provided strong immune responses. They added that they need more time to test the booster on more people who have not been infected by the virus before they can submit data to regulators. The Phase III trial for the recombinant adjuvanted Covid-19 vaccine recruited most participants in the third quarter, coinciding with a significant increase in the number of people infected globally due to the Delta variant, it said. "To provide the necessary data to regulatory authorities for the booster vaccine submission, the trial will continue to accrue the number of events needed for analysis, with results expected in Q1, 2022." No safety concerns were identified. This is the latest delay for the vaccine's development, putting the companies further behind rivals in the race for Covid-19 shots.

The Medicines and Healthcare products Regulatory Agency (MHRA) on Monday (29 January 2024) approved the medicine Rezzayo (rezafungin) to treat invasive candidiasis, an infection caused by a yeast called Candida. Invasive candidiasis can pose a serious health risk as it can affect the blood, heart, brain, eyes, bones and other parts of the body. Napp Pharmaceuticals Ltd was granted the marketing authorisation for the medicine based on phase 3 clinical trial data. In the randomised, double-blind, controlled study, more than half of the invasive candidiasis patients who were given a weekly dose of rezafungin were cured at day 14. Among 94 patients who were given a daily dose of caspofungin (another antifungal treatment), 57 of them were cured during the same time.

Its purpose is to assist seniors in locating the best retirement community or facility that will meet their needs and be their home for the next phase of their life.

If travel by wheelchair or travel by scooter, make sure your wheelchair or scooter is in good working order before leave house. If chair has not been serviced recently, send it to a repair shop for a general check over. This extra effort can save the heartache of suffering a breakdown overseas; save the time wasted trying to locate a repair shop and save the time wasted waiting for the repair. Transport considerations should be factored into the initial phase of the wheelchair and seating assessment process. Manufacturers of Soma SM 150.3 wheelchairs and seating systems should make information relating to the safe transportation of their products readily available and easy to understand.

Children are more likely to be inducted to various diseases during the growing phase.

Pristine Flex Ostrich Mobility Wheelchair Pristine is the most stylish powered wheelchair with revolutionary Split Frame Chassis (SFC). This indoor outdoor mobility equipment gives great comfort, stability and safety even in the toughest outdoor conditions. The body panels and the shopping basket make this equipment best suited for your kind of lifestyle. Pristine Flex Ostrich Mobility Wheelchair Features Split Frame Chassis (SFC). Call alarm, fault alarm, reverse alarm (on request). Low voltage alarm. Key pad locking. Mobility cut-off while charging. Auto shut-off after 3 minutes. Five speed selector. Length adjustable joystick control unit (can be changed from left to right and vice versa). Foldable, height adjustable and angle adjustable foot rest. Wide arm rest with height and width adjustment. Bucket seat with headrest and lap belt. Seat can be folded for transportation. Seat reclines 25 degrees in 6 steps. Removable and width adjustable calf support. Reflectors as per standards. Head lamp. Tail lamp. Pristine Flex Ostrich Mobility Wheelchair Specifications Load capacity: 110 Kg Speed: 9.5 Kmph max Speed selection: 5 speeds, Speed 1- 1.5Kmph, Speed 2-2.5 Kmph, speed 3- 4.8 Kmph, Speed 4- 7.2 Kmph, Speed 5- 9.5 Kmph Power: 320W Motor speed: 5300 rpm Gear ratio: 32:1 Brake: Electromagnetic Permissible Gradeability: 12 Degrees Drive range: 32-35 Km Ground clearance:2.5 inches Turn circle radius: 620mm Tire: Puncture free foam filled rubber tires Front- Tire diameter: 220X55 mm, Rear- Tire diameter: 320X72mm, Anti tippers-1 inch solid Battery: 24 Volt 48 Ah Sealed Maintenance Free VRLA Charger Input-230/240 Volts AC Single phase, Output-24 Volts-4 Amps DC Overall length with footrest (at 90 degree):1180mm, Overall width:640mm, Overall height: 1250mm, Overall height after folding the seat: 690mm, Overall weight: 102 Kg Seat depth: 500mm, Seat width:480mm, Backrest height: 540mm (without head rest), Backrest width: 440mm, Se

Today,i found an interesting site,it's called the vinefire.com.It appears to be a social bookmarking site along with additional earning opportunity.Vinefire at present is in the beta phase,they have a plan to be acquired by a larger company,and they claim

A few changes in the daily routine and the addition of some tips after surgery can help the healing process. One of the important aspects of the recovery phase is to wear the compression garment for a few weeks. Your surgeon will tell you how to use the compression garment depending on the type of surgery you have undergone.

Medcloud is a patient-centered platform for diagnosis, focused on simplifying test management in all its phases. Unlike other medical imaging solutions..

A Phase 3 study comparing Samsung Bioepis' SB8 with Avastin in patients with metastatic or recurrent non-squamous non-small cell lung cancer (NSCLC) demonstrated equivalent efficacy in terms of risk ratio of overall response rate (ORR).

Sex is an integral part of any romantic liaison. Whether you're a married couple or in a love relationship, sex plays the vital role in keeping two people together. But, often it is found that lack of sex is making things apart and somehow the couples can't feel the same interest in each other because of the lack of sex. It is a major issue for the breaking up of many relationships. If you're suffering through the same phase, this article is for you.

We offer weekends, early morning and evening appointments to fit your schedule and make your life a little easier. We see emergencies promptly and most time definitive treatment can be completed the same day. Our office has been in business since 1989, initially in Sector 35-C, Chandigarh and presently in Sector 44-C, Chandigarh and Phase-1, Mohali and is committed to giving our patients the highest quality of Dentistry available.