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The pharmacy chain has already announced plans to permanently close hundreds of its branches across the UK to consolidate its portfolio of 2,200 stores to 1,900. Two of its branches in North Wales will be closed next year, with its site in Rhos on Sea set to close its doors in March 2024 and the shop in Colywn Bay the following month. In a statement obtained by The Sun, Clwyd West MP David Jones has branded the closures "hugely bad news for the local community". He added that it is not "a case of simple shop closures," but "another body blow for the local retail economy." The Station Road shopping centre, where the Colwyn Bay store is located, has already seen the closure of several other prominent stores, including WHSmith, the MP stated. The closure of two Boots stores will leave many people "extremely worried as to how they will be able to obtain essential medicines," he added.

Boots has shut down three more stores, as it moves forward with its plan to close 300 stores across the UK over the next 12 months. On Saturday (18 November), Boots closed its branches in Mudge Way, Plymouth; Mount Pleasant Road, Exeter; and Low Moor Road, Kirkby, Ashfield. The NHS issued a memo to shoppers and patients who use the Plymouth branch, which is located next to Plympton Health Centre, to inform them that "you will need to find and nominate another pharmacy to dispense your prescriptions going forward." Patients can set their nomination by contacting their new pharmacy and requesting "they do this for you." According to DevonLive, a note was attached to the Mount Pleasant pharmacy door that read: "Boots Mount Pleasant Store will close on Saturday, November 18 2023.

Boots customers were left disappointed as the retail giant closed three more branches, two in Kent and one in Glasgow. On Sunday 21 January, Boots' branches in Cliftonville and Biggin Hill were closed, forcing locals to find an alternative pharmacy, Express.co.uk reported. Cliftonville residents have taken to social media to express their disappointment over the closure of their local pharmacy on Northdown Road. Even though there is another Boots branch in Margate, they said that Cliftonville branch is "much more accessible, with parking available right outside, on the bus route and surrounded by a residential area within easy walking distance." One resident has branded the retailer's decision as "crazy", as per the news portal.

Over a century-year-old Boots pharmacy in St James's Street, Brighton shut its doors permanently on Saturday (20 January) leaving the communities disappointed. The branch in Kemp Town, which was opened to the public for the first time in 1914, was supposed to close on November 19 last year but continued trading into the new year, The Argus reported. Locals are not happy with the retailer's decision to close the store as some say it used to be "always busy with prescriptions and people buying things." Another person recalled that Boots had earlier closed two pharmacies, one on Lewes Road, Brighton, and another on Church Road, Hove. The American-owned health and wellbeing chain is in the process of closing more UK branches in the coming months as it's targeting to reduce its store portfolio to 1,900 from 2,200.