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Tom Fields

Alerts and Decision Support for Abnormal Laboratory Values Do Not Improve Clinical Mana... - 0 views

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    The program had no impact on the clinical management of these patients or the frequency of adverse events. Program developers nonetheless believe the approach could be highly effective if the alerts and decision support were better integrated into existing workflow and the system made easier to use. They are working on these refinements and plan to test a revamped program in the future.
Dr.Ravichandra Karkal

WORKUP AND DIAGNOSIS OF A SOLITARY THYROID NODULE from Townsend: Sabiston Textbook of S... - 3 views

  • Rapid growth and signs of possible invasion, such as pain or hoarseness, are most suggestive, but not conclusive of malignancy
  • Clinical groups with the highest risk for malignancy in a thyroid nodule are children, males, adults younger than 30 or older than 60 years, and those exposed to radiation therapy, especially during childhood
  • history of specific endocrine disorders
    • Dr.Ravichandra Karkal
       
      medullary carcinoma, MEN 2, or papillary thyroid cancer (PTC), or a history of familial polyposis, including Gardner's syndrome.
  • ...9 more annotations...
  • Serum Tg has been reported as useful in predicting a well-differentiated carcinoma
  • Radioisotope Scanning
  • radionuclide scans allow assessment of thyroid function.
  • Technetium pertechnetate (99mTc) is taken up rapidly by the normal activity of follicular cells. It is trapped by follicular cells, but not organified. 99mTc has a short half-life and low radiation dose. Its rapid absorption allows quick evaluation of increased uptake (so-called hot) or hypofunctioning (so-called cold) areas of the thyroid.
  • 123I and 131I iodine scintigraphy is also used to evaluate the functional status of the gland
  • Advantages of scanning with 123I include a low dose of radiation (30 mrad) and short half-life.
  • 123I is a good choice for evaluating suspected lingual thyroids or substernal goiters.
  • 131I has a longer half-life (8 days) and emits higher levels of β-radiation. 131I is optimal for imaging thyroid carcinoma.
  • screening modality of choice for the evaluation of distant metastasis.
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