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A three-wheeled wheelchair was built in 1655 or 1680 by a disabled German man, Stephan Farffler, who wanted to be able to maintain his mobility. Since he was a watch-maker, he was able to create a vehicle that was powered by hand cranks. In 1789, two French inventors developed a three wheeled vehicle, powered by pedals; They called it the tricycle. 19th century tricycle used in Iran In 1818, British inventor Denis Johnson patented his approach to designing tricycles.[clarification needed] In 1876, James Starley developed the Coventry Lever Tricycle, which used two small wheels on the right side and a large drive wheel on the left side; power was supplied by hand levers. In 1877, Starley developed a new vehicle he called the Coventry Rotary, which was "one of the first rotary chain drive tricycles." Starley's inventions started a tricycling craze in Britain; by 1879, there were " twenty types of tricycles and multi-wheel cycles ... produced in Coventry, England, and by 1884, there were over 120 different models produced by 20 manufacturers." The first front steering tricycle was manufactured by The Leicester Safety Tricycle Company of Leicester, England in 1881 which was brought to the market in 1882 costing £18. They also developed a folding tricycle at the same time.Buy online Tricycle for handicapped and disabled at lowest price and cheap cost in india from wheelchair india online shopping store of Tricycle manufacturer, distributor, dealer and supplier of variety of Tricycles at low price in india for handicapped and disability product like Disabled Tricycle Deluxe Double Hand Drive, Tricycle Deluxe Single Hand Drive, Tricycle Standard Double Hand Drive, Tricycle Regular Single Hand Drive, Standard Single Hand Drive Tricycle, along with that we offer huge discount. Tricycles were used by riders who did not feel comfortable on the high wheelers, such as women who wore long, flowing dresses. In the UK, upright tricycles are sometimes referred to as "ba

A three-wheeled wheelchair was built in 1655 or 1680 by a disabled German man, Stephan Farffler, who wanted to be able to maintain his mobility. Since he was a watch-maker, he was able to create a vehicle that was powered by hand cranks. In 1789, two French inventors developed a three wheeled vehicle, powered by pedals; They called it the tricycle. 19th century tricycle used in Iran In 1818, British inventor Denis Johnson patented his approach to designing tricycles.[clarification needed] In 1876, James Starley developed the Coventry Lever Tricycle, which used two small wheels on the right side and a large drive wheel on the left side; power was supplied by hand levers. In 1877, Starley developed a new vehicle he called the Coventry Rotary, which was "one of the first rotary chain drive tricycles." Starley's inventions started a tricycling craze in Britain; by 1879, there were " twenty types of tricycles and multi-wheel cycles ... produced in Coventry, England, and by 1884, there were over 120 different models produced by 20 manufacturers." The first front steering tricycle was manufactured by The Leicester Safety Tricycle Company of Leicester, England in 1881 which was brought to the market in 1882 costing £18. They also developed a folding tricycle at the same time. Tricycles were used by riders who did not feel comfortable on the high wheelers, such as women who wore long, flowing dresses. In the UK, upright tricycles are sometimes referred to as "barrows". Many trike enthusiasts ("trikies") in the UK belong to the Tricycle Association, formed in 1929. They participate in day rides, tours and time trials. Massed start racing of upright tricycles is limited to one or two criteriums such as in Bungay, Suffolk each year.

The research of Conolidine as a pain reliever is a milestone in pain management, attributed to pioneering efforts in pharmacology and natural compound research. Known for its unique pain-relieving properties without addictive risks, Conolidine's potential lies in its natural origins and the innovative mind that recognized its value. The inventor of Conolidine has done thorough research on the bark of the crepe jasmine plant and also paid attention to Taebermontana Divaricata and its usage in traditional medicines. His contributions from isolation to the refining of the Conolidine compound are commendable to ensure this compound for safe, modern therapeutic use. The invention of Conolidine represents a new era in pain management, especially amid rising concerns over opioid addiction and dependency issues. The inventor's work has brought forward a solution that addresses chronic pain while bypassing the common side effects of traditional pain medications. Thanks to this innovative contribution, Conolidine has paved the way for future research into other plant-based compounds, inspiring hope for more natural and accessible health solutions. The Conolidine inventor has not only introduced a potentially life-changing product but has also set a precedent for the future of natural medicine and pain relief.

Dr Michael Gamlen, the inventor of Gamlen instruments presents a tablet press machine to the students at the School of Pharmacy on 16 October. The equipment not only solves the challenge of producing lab-scale tablets under precise conditions but also offers valuable insights into material compaction properties. It is also known as a powder compaction analyser which has been given on loan to the University of Sunderland for five years. Dr Gamlen talks about the machine and how pharmacy students will benefit, saying: "It allows you to make tablets under tightly controlled conditions and enables you to make accurate comparisons between different materials and processes. "The students will be able to easily see the impact of the tablet compaction conditions on tablet properties. This is very important to understand when developing new tablet formulations and manufacturing products."

Computer Science Tuesday, April 25, 2023 Computer hardware Computer hardware is the physical components that make up a computer system. It includes everything from the central processing unit (CPU) to the monitor, keyboard, and mouse. Understanding the different types of hardware and how they work together is essential for anyone who works with computers. In this article, we will explore the various components of computer hardware, including internal and external components, and the peripherals that connect to them. We will also discuss the importance of hardware maintenance, the latest advancements in computer technology, and factors to consider when choosing the right hardware for your needs. Whether you are a computer technician, a gamer, or simply someone who uses a computer for everyday tasks, this article will help you better understand the world of computer hardware. Introduction to Computer Hardware Computer hardware refers to the physical components that make up a computer system. It includes everything from the processor and memory to input/output devices such as the keyboard and monitor. In this article, we will explore the different types of computer hardware and their functions. What is Computer Hardware Computer hardware refers to the physical components of a computer system. It includes all the components that can be touched, seen, and used to interact with a computer, such as the monitor, keyboard, and mouse. Hardware is different from computer software, which refers to the programs and applications that run on a computer system. History of Computer Hardware The history of computer hardware dates back to the 1820s when Charles Babbage, an English mathematician, and inventor, designed the first analytical engine, which was considered to be the first mechanical computer. With time, more complex electronic computers were developed, including the first Intel microprocessor in 1971. Since then, computer hardware has continued to evolve, becoming

The Medicines and Healthcare Products Regulatory Agency (MHRA) has authorised an innovative and first-of-its-kind gene-editing treatment for sickle-cell disease and transfusion-dependent β-thalassemia. Known as Casgevy (exagamglogene autotemcel), the treatment is based on the innovative gene-editing tool CRISPR, for which its inventors were awarded the Nobel Prize in 2020. Casgevy is the first medicine to be licensed that uses CRISPR, and it is to be used for treating patients aged 12 and over. To date, a bone marrow transplant has been the only permanent treatment option for these life-long conditions, which in some cases can be fatal. The MHRA's authorisation came after a rigorous assessment of its safety, quality and effectiveness.