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Immunogenicity refers to the capacity of a vaccine to provoke an immune response in the body. An effective immune response is characterized by the production of specific antibodies, activation of immune cells, and the development of immunological memory. The goal is to elicit a durable and robust response that can prevent or control infections. Leveraging Viral Vector Technology Viral vectors serve as essential vehicles for delivering antigenic proteins or genetic material into target cells, triggering an immune response. Biotechnology companies have been exploring advanced strategies to optimize viral vector design, aiming to enhance immunogenicity and improve vaccine effectiveness. Vector Selection: The choice of viral vector plays a crucial role in determining immunogenicity. Different viruses have unique properties and characteristics that can impact immune responses. Biotechnology companies meticulously select viral vectors that possess the desired attributes, such as the ability to infect target cells efficiently and induce strong immune responses. Genetic Engineering: Advanced genetic engineering techniques are employed to modify viral vectors, tailoring them to specific vaccine requirements. By introducing specific antigenic proteins or genetic material, researchers can stimulate the immune system to mount a targeted response. This precise manipulation enhances the vaccine's ability to elicit a robust immune reaction. Immunomodulatory Elements: Biotechnology companies are incorporating immunomodulatory elements into viral vector designs. These elements can enhance the immune response by stimulating various components of the immune system, such as antigen-presenting cells and T cells. By activating and priming these immune cells, the vaccine can generate a more potent and sustained immune response. Adjuvants: Adjuvants are substances added to vaccines to enhance their immunogenicity. They stimulate and amplify the immune response, improving the va

The NHS's latest report on ambulance services in England for March 2024 reveals significant progress in response times for emergency calls across all categories compared to recent months. The Ambulance Quality Indicators (AQI) Statistical Note, released in April, underscores both improvements and persistent challenges within the sector. Recent figures obtained from the Liberal Democratic party suggest ongoing struggles with response times, particularly for category two patients, which may include individuals experiencing strokes or heart attacks requiring a response within 18 minutes. Similarly, in November last year, ambulance waits for category 2 calls surged to their highest level since December 2022, reaching 93 minutes, after dropping to 32 minutes in January 2023 according to the British Heart Foundation. However, according to the latest statistical figures obtained from AQI, March 2024 witnessed the shortest average response times for all four categories of emergency calls since August 2023.

New legislative orders approved by the Privy Council will give the General Pharmaceutical Council (GPhC) and Pharmaceutical Society of Northern Ireland (PSNI) powers to set professional standards for Responsible Pharmacists, Superintendent Pharmacists and Chief Pharmacists. The Pharmacy (Preparation and Dispensing Errors - Hospital (and Other Pharmacy Services) Order 2022 and the Pharmacy (Responsible Pharmacists, Superintendent Pharmacists etc.) Order 2022 have been published and are expected to come into force in December 2022. Trevor Patterson, Chief Executive of the Pharmaceutical Society NI said: "We have been working with our colleagues in the GPhC and Government for some time on these two pieces of important legislation and we are delighted they have now reached the statute books. "Both Orders enable and enhance the powers we, and the GPhC, have to define the roles and responsibilities of Responsible, Superintendent and Chief Pharmacists, respectively. They also create protections against criminal prosecution for hospital pharmacists where an inadvertent error is made either in dispensing or assembly, in certain defined circumstances, similar to the protections available to colleagues working in community/registered pharmacy settings. Provisions that allow the appointment of a Deputy Registrar for our organisation will also be introduced.

Duncan Rudkin, the CEO of the General Pharmaceutical Council (GPhc) has highlighted the importance of strengthening pharmacy governance to provide clarity around how pharmacies are organised and managed. This will ensure that patients and the public continue to receive safe and effective pharmacy care, he said while speaking at the annual Sigma Conference in London on Sunday (5 November). According to him, there could be rules that outlined the essential roles and responsibilities of responsible pharmacists, and professional standards for responsible pharmacists, superintended pharmacists and chief pharmacists. He also announced that the GPhC will be shortly launching a consultation to integrate a new set of standards for the statutory role of hospital chief pharmacists "which up until recently has never been recognised in law." It is expected to be launched by early January 2024. However, Duncan, emphasised that they cannot start the work on standards for responsible and superintendent pharmacists until they know the government plans in relation to supervision. "Because of course, the responsible pharmacists' regime, and the supervision regime are in many ways intertwined, and can't certainly be looked at separately.

Prime minister Rishi Sunak appointed Conservative MP for North East Cambridgeshire Steve Barclay as secretary of state for health and social care on 25 October 2022. He previously held the same role between 5 July and 6 September - after Sajid Javid resigned as health secretary. As head of the Department of Health and Social Care (DHSC) his responsibilities will include "overall financial control and oversight of NHS delivery and performance" as well as "oversight of social care policy". Mr Barclay was succeeded by Thérèse Coffey, who thanked her "great ministerial team" at the DHSC in a Tweet, before taking up her new responsibility as environment secretary in the new cabinet. As head of the Department of Health and Social Care (DHSC) his responsibilities will include "overall financial control and oversight of NHS delivery and performance" as well as "oversight of social care policy". Mr Barclay was succeeded by Thérèse Coffey, who thanked her "great ministerial team" at the DHSC in a Tweet, before taking up her new responsibility as environment secretary in the new cabinet.

Businesses have a responsibility for the safety of their employees, as well as visitors that are on their premises. If an injury occurs on their property, a company can be held responsible. There are various issues and rules that may apply, so it is important to know the facts regarding such situations. Here are 4 impacts legalities to consider for your business when dealing with such incidents. STATUS OF ENVIRONMENT AND RESPONSIBILITY OF PREMISES When you are looking into injury cases that occur and involve the premises or property of a business, one of the most important aspects to consider is the status of the property itself. All property that has access to the public owned by an individual or business must be maintained in a manner that is safe for people to reasonably move around. This is often associated with sidewalks and pathways, as well as corridors, hallways, and various rooms in businesses. You must ensure that areas where people may be around are safe such as ensuring no water or substance is present on floors that would cause falls or slips, and otherwise having the signage to indicate the need for caution. This is not limited to people, but can also apply to vehicles and equipment, ensuring oil stains and spills do not endanger the operators and employees in the area. Businesses should recognize any risks that are present and also be mindful to address environmental concerns in the immediate area as they are made aware of them. If a business fails to address such potential dangers, they are indeed potentially liable for any injuries and health concerns that come as a result of willful ignorance of the situation.

The Department of Health and Social Care (DHSC) has published its response to the 2016 hub and spoke consultation which has paved the way for a new discussion following engagement with community pharmacies and other stakeholders this year. The response showed that many respondents supported use of hub and spoke dispensing models in independent pharmacies, but expressed concerns about some practicalities related to it. Respondents raised concerns around "patient data, liability, implications for the supply chain, and risks to the existence of small community pharmacies." They also raised question about the speed of access to medicines in an emergency and security of data transfers between hubs and spokes, DHSC stated.

The Pharmacists' Defence Association (PDA) has raised concerns over "certain elements" of the Pharmaceutical Society of Northern Ireland (PSNI)'s consultation on pharmacy staffing levels. PSNI recently consulted on its draft guidance for pharmacy staffing levels which sets out to explain what pharmacy owners and superintendents must do to ensure that each pharmacy has enough skilled and qualified staff. This includes having an appropriate skill mix, to provide safe and effective pharmacy services which comply with the standards. PDA said that the role of the 'responsible pharmacist' has not been "fully acknowledged" and that more clarification is needed. The association has made a few recommendations to PSNI that includes: the guidance must explicitly recognise the statutory role of the responsible pharmacist and their authority in securing the safe operations within the pharmacy. "The guidance should specify that pharmacy owners and superintendents must ensure that they do not set incentives or targets which may compromise the professional judgement of staff." It also recommended that unregistered staff (including unregistered managers) are accountable firstly to the responsible pharmacist for any activity involving the clinical care of patients (for example unregistered managers must not interfere in diary bookings for vaccinations).

Community pharmacies must be involved in future planning for public health emergencies, especially in cases where a quick response is needed such as the Covid-19 pandemic, a European-wide research has recommended. The project, co-led by the University of Huddersfield professor Zaheer-Ud-Din Babar in medicines and healthcare, focuses on how community pharmacies dealt with the pandemic, covering 31 pharmacy interventions on Covid-19 in 32 countries in Europe. The interventions include prevention, response, and recovery measures. It also covers improved access to medicines, expanded powers granted to pharmacies, rapid antigen testing, along with Covid-19 vaccination. Community pharmacists in the US, Canada, and Australia have been engaged in pandemic prevention, preparedness, and response strategic guidance after the 2009 flu pandemic. The aim of the research is to map the current reported practice and trends and review the pharmacies' intervention in Europe.

If you want to start your day feeling refreshed and energized, consider creating a daily regimen of ginger shots instead! Ginger shots are like taking ginger ale straight to the source. They give you all sorts of vitamins, minerals, and antioxidants your body needs to feel its best. These shots are beverages made from concentrated doses of ginger root (Zingiber officinale), which are asserted to aid in warding off sickness and strengthen your resilience against many health conditions. However, ginger shots just became prevalent recently in the wellness society; ginger brews have been used since ancient times to cure a host of ailments. While ginger presents unique health features, you may wonder whether sipping ginger shots is healthful. This article inspects ginger shots, including their potential health benefits, side effects, and preparation at home. Ginger Shots Ginger shots are potent drinks made with fresh ginger root. The ingredients used in the shot differ depending on the recipe you want to try. Some shots include only fresh ginger juice, while others comprise lemon juice, orange juice, turmeric, cayenne pepper, and/or manuka honey. You can make it at home by squeezing fresh ginger root juice or blending fresh, grated ginger with different juices, like lemon or orange. Now you can see that these shots are available pre-made or made to take away at juicers or health food stores. You can also beat them up at home by operating a juicer machine. For this, just add freshly grated ginger to citrus juice or mix a dash of ginger with other ingredients in a high-powered blending pot. You may find ginger shots spicy and unpleasant to drink owing to their high content of ginger roots. Hence, they're made in small amounts and generally drunk in one or two swigs. Ginger Root Ginger root has been used medicinally for thousands of years. The ancient Chinese used it to treat stomach problems, colds, and inflammation. According to the National Institute of Health (NIH

While thanking the provisionally registered pharmacists and their employers for supporting NHS services during the pandemic, the General Pharmaceutical Council (GPhC) has asked the 63 eligible candidates to join the main register by January 31 to continue practicing. A total number of 4,799 provisionally-registered pharmacists have been on the provisional register since it was introduced in July 2020 in response to the Covid-19 pandemic, which had affected the registration assessment schedule. As of Tuesday (January 18), 237 were still on the provisional register, of which 84 have begun the process to join the main register, 90 did not sat an assessment, while 63 eligible candidates are yet to start their application. The register enabled trainees who had completed their training to support NHS services and provide patient care effectively as provisionally-registered pharmacists, while they waited to sit the registration assessment. After providing three potential opportunities to trainees to sit the registration assessment - in March, July and November 2021, the provisional register will close on January 31, 2022.

The Pharmacists' Defence Association (PDA) has advised its member to check their understanding of what activities can legitimately take place when no RP is signed in at the pharmacy or the absence provisions are used. The advisory to its member was followed after noticing a considerable talk on social media about compliance with the Responsible Pharmacist (RP) regulations which also included unauthorised activity occurring when no RP is signed in. "There have been comments made that some pharmacists and pharmacy team members may fear repercussions from challenging or whistle-blowing about such behaviour," PDA said. "To assist members with the interpretation of the RP regulations, the PDA has made available a legal briefing note about the RP regulations produced by a specialist pharmacy regulation law firm." It further added: "Non-compliance with the regulations by pharmacy teams should be reported to the pharmacy superintendent."

The Community Pharmacy Workforce Development Group (CPWDG) has called upon policymakers to take action in response to the 2022 Community Pharmacy Workforce survey for England, which revealed a significant workforce reduction. The survey found a steady decrease in the number of full-time equivalent (FTE) pharmacists, pharmacy technicians, and pharmacy support staff from 2017 to 2022, with no signs of a slowdown. In response, it presented four recommendations to the Government and the NHS, aimed at ensuring that the sector can effectively adapt to the evolving needs of patients. CPWDG's findings indicate that vacancy rates are on the rise, reaching nearly 25 per cent, or 1 in 4 roles, in certain regions, accompanied by a noticeable shift in working patterns.

RPS Scotland has named Fiona McIntyre as its new Policy and Practice Lead. With a background in hospital pharmacy, McIntyre will be responsible for policy development and professional support at RPS Scotland, and is set to assume her new role in early October. McIntyre will assume a leadership role for specific projects across Great Britain, collaborating with the Policy and Practice Leads in England and Wales, RPS Scotland said in a statement. Her responsibilities include representing pharmacists in working groups and meetings, engaging with pharmacists and pharmacy organisations, and supporting the RPS Director for Scotland. "During my career in NHS Scotland, I have advocated for pharmacy teams whenever possible," said McIntyre. "I am passionate about the profession's role in the safe and effective use of medicines, and I'm privileged to join the RPS. I look forward to promoting pharmacy in Scotland and helping our profession reach its full potential." "I'm pleased that Fiona will be joining the RPS Scotland team as our policy lead," said Laura Wilson, Director for RPS Scotland. "Fiona's experience will be invaluable to the role, and the whole team looks forward to her starting with us in October."

The National Health Service will begin its autumn Covid vaccine program next week, a month earlier than planned in response to the spread of a new variant dubbed Pirola. Covid vaccines will be administered to care home residents and housebound individuals from Monday onwards, while over-65s and other vulnerable groups will receive their appointments the week after. On Aug. 30, NHS England shifted the autumn vaccination drive to start on September 11 in response to the new Covid-19 variant, BA.2.86, detected on August 18. The primary groups can book through a national system upon receiving an invitation from the NHS. Some people may get an earlier call from their GP, and a few have already scheduled Covid vaccinations alongside their flu jabs. The NHS will begin inviting other eligible groups from Sept. 18. However, it is important to note that not everyone will receive a call at the same time. These groups will include individuals aged 65 and over, those aged six months to 64 years in a clinical risk category, frontline health and social care workers, and individuals aged 12 to 64 who are carers or household contacts of those with immunosuppression.

In its response to the Health and Social Care Committee inquiry into 'Digital Transformation in the NHS', the Community Pharmacy IT Group (CP ITG) has highlighted issues concerning the NHS community pharmacy. CP ITG, of which PSNC is a member, has urged that pharmacy teams should have access to up-to-date records information, e.g. from Shared Care Records, GP Connect and Summary Care Records with Additional Information. It has also stated that the Booking and Referral Standards (BaRS) should be extended so that future referrals into and from pharmacy can be communicated seamlessly. In its written response, CP ITG said: "Ensure that BaRS is expanded and aligns with other referral IT standards such as GP Connect referrals. Ensure it is used across community pharmacy, the GP sector, other health care sectors and across the NHS, and by all health IT suppliers, so that messages and referrals can flow smoothly within and across sectors and patients can have a seamless experience and safe care." The group has asked the Health and Social Care Committee to create a framework for the development of pharmacy IT to ensure IT suppliers are better equipped to support pharmacy teams and their delivery of services.

The Pharmaceutical Services Negotiating Committee (PSNC) has appointed Robbie Turner as chief transformation officer, to work closely with LPCs as part of its newly launched Transforming Pharmacy Representation (TAPR) programme. PSNC launched the TAPR Programme in response to the contractor vote in favour of the Review Steering Group's proposals. As part of the programme - alongside actioning the recommendations for PSNC - there will be support for LPCs to implement their proposals. Williams will be responsible for leading, driving, and having oversight of the TAPR workstream to increase efficiency and outcomes across the network of LPCs in England. This will include the provision of specialist hands-on guidance and support to LPC members and officers, to promote implementation of the RSG proposals, best practice and challenging the status quo. Williams was formerly chief officer of Community Pharmacy West Yorkshire LPC and subsequently Director for England and Director of Pharmacy and Member Experience at the Royal Pharmaceutical Society.

he Pharmacy Schools Council (PhSC) has elected Professor Katie Maddock as the organisation's new chair. Prior to becoming head of school at Keele University, Professor Maddock had been MPharm course director and associate dean for education for the Faculty of Medicine and Health Sciences, responsible for developing the clinical teaching at Keele. Before joining Keele University, she taught clinical pharmacy and pharmacy practice at Aston University. Her research interests lie in pharmacy education, particularly the use of technology in teaching, clinical therapeutics, augmented reality simulation and interprofessional education. She was also awarded a principal fellowship of the Higher Education Academy in November 2020. Having worked in hospital pharmacy, Professor Maddock is acutely aware of the pressures that Covid-19 has placed on healthcare, as well as the importance of retaining and building upon the positive changes to patient care and pharmacy practice that were developed in response to the pandemic.

Britain has become the first country to approve a Codiv-19 vaccine that targets both the original and Omicron variant of the virus. Medicines regulator MHRA approved the so-called bivalent vaccine made by US drug company Moderna as a booster for adults. The agency's decision was based on clinical trial data that showed the booster triggered "a strong immune response" against both Omicron (BA.1) and the original 2020 virus, it said. The MHRA also cited an exploratory analysis in which the shot was also found to generate a good immune response against the currently dominant Omicron offshoots BA.4 and BA.5. "The first generation of Covid-19 vaccines being used in the UK continue to provide important protection against the disease and save lives," MHRA chief executive June Raine said in a statement. "What this bivalent vaccine gives us is a sharpened tool in our armoury to help protect us against this disease as the virus continues to evolve."

In a mutual agreement with the STADA board, Roger Scarlett-Smith has stepped down from his role as head of UK. The company has assigned the responsibility of UK operation to Rudolf Bär with current responsibilities as cluster head for Mid-Sized European Markets. Scarlett-Smith joined STADA in October 2018 to lead the UK operation upon the retirement of Dieno George. Prior to this, he had enjoyed an illustrious career in the Consumer Healthcare sector, largely with GlaxoSmithKline, for which he held positions including as President North America, President EMEA and Head of Global Categories. Under his leadership, the STADA UK business has grown sales by 50 per cent and profitability has more than doubled. He has reshaped the business to improve efficiency. There has been a marked acceleration of product innovation including key line extensions to the Zoflora disinfectant range as well as the introduction of a salmeterol and fluticasone inhaler in the Rx respiratory sector. Meanwhile, T+R has developed a fine reputation regionally, being voted number 1 regional company last year and winning many national industry awards.