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British drugmaker GSK has signed deals with three companies allowing them to make inexpensive generic versions of its long-acting HIV preventive medicine for use in lower-income countries, where the majority of new HIV cases occur. The injected drug cabotegravir is approved by regulators in Britain and the United States. Last July, GSK announced a program with the United Nations-backed healthcare organisation, the Medicines Patent Pool, aiming to get poor countries access to new HIV therapies far earlier than they did for previous HIV medicines. During the HIV/AIDs epidemic in Africa in the 1990s and early 2000s, in which many millions of people died, treatments used widely in wealthy countries were unavailable on the continent. GSK said last year the new program could result in the generic form of its injection being available in lower-income countries beginning in 2026. The drugmaker's HIV treatment division, ViiV Healthcare, said in a statement on Wednesday it had issued voluntary licenses - waiving intellectual property rights - to Aurobindo, Cipla and Viatris, which will manufacture the generic versions of injectable cabotegravir.

Esperion Therapeutics' non-statin therapy "bempedoic acid" has shown modest results in reducing the risk of major cardiovascular events in statin-intolerant patients in the cholesterol lowering via bempedoic acid, an ACL-inhibiting regimen (CLEAR Outcomes) trial, revealed GlobalData, a leading data and analytics company. As a result, there is substantial room for improvement in this space as a potential approval is expected in Australia in near-term based on these results, said GlobalData. According to GlobalData's Pharmaceutical Intelligence Center, the total number of diagnosed prevalent cases of dyslipidemia in Australia is expected to increase at a compound annual growth rate of approximately 1.2% from 5.2 million in 2022 to 5.4 million in 2025. Neha Myneni, Pharma Analyst at GlobalData, comments: "Bempedoic acid joins several statin alternatives that have shown the potential to reduce cardiac illnesses. However, with not much significant improvement in the outcomes, there exists a clear room for improvement for non-statin therapies in this space." Bempedoic acid is the sixth class of cholesterol-lowering drugs (other than cholesteryl-ester transfer protein isoform (CETPi) inhibitors), that has demonstrated the potential to reduce heart attacks and strokes. Other class of therapies with similar potential currently marketed in Australia include statins, bile acid resins, niacin, ezetimibe, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors (alirocumab, evolocumab, and inclisiran).

One type of bacteria found in the gut may contribute to the development of Type 2 diabetes, while another may protect from the disease, according to early results from an ongoing, prospective study led by investigators at Cedars-Sinai. The study, published in the peer-reviewed journal Diabetes, found people with higher levels of a bacterium called Coprococcus tended to have higher insulin sensitivity, while those whose microbiomes had higher levels of the bacterium Flavonifractor tended to have lower insulin sensitivity. Mark Goodarzi, the director of the Endocrine Genetics Laboratory at Cedars-Sinai in Los Angeles, California, is leading an ongoing study that is following and observing people at risk for diabetes to learn whether those with lower levels of these bacteria develop the disease. "The big question we're hoping to address is: Did the microbiome differences cause diabetes, or did diabetes cause the microbiome differences?" said Goodarzi, who is the senior author of the study and principal investigator of the multicenter study called Microbiome and Insulin Longitudinal Evaluation Study (MILES).

Women who are trying to conceive should stop vaping as it may affect fertility, a study by the women's health firm Hertility has suggested. Analysis of blood samples from more than 8000 women revealed that vapers and smokers have lower levels of anti-mullerian hormone (AMH), which indicates how many eggs women have left in their ovaries. Across all age groups, AMH levels were found to be lower in people who vaped than non-vapers, suggesting that vaping could accelerate age-related decline in egg reserve. Concerningly, the report revealed that one in five British women vape while trying to get pregnant, with a significant portion also engaging in other lifestyle "vices" such as alcohol, drugs and smoking.

(2) Plank Although a simple pose to presume, it happens to be one of the most useful of the abdominal muscle exercises. Stay horizontal on your stomach with your hands placed precisely below your shoulders. Your heels should be off the ground and toes curled under. Slowly, lift your body as you straighten out your hands. Your weight should be balanced on your hands and on the toes. Hold this position, approximately for 1 minute, and release thereafter for a stronger core.

A tricycle for special needs is made so can go along for the ride in wheelchair or sitting in a special seat, both of which are attached right in front of another adult's trike. Tricycles to accommodate a vast array of special needs. Hand-pedaled recumbent tricycles are available for those without the use of their legs. Children, teens and adults with cerebral palsy and similar disorders can select tricycles specially designed to increase strength and coordination. Caregivers to autistic children can ride with their child on tandem special needs tricycles built to accommodate one adult and one child rider. Accessories are also available to convert standard trikes to suit specific needs. The objective of tricycle design is to produce wheelchairs that perform well and can provide appropriate seating and postural support without compromising strength, durability and safety. A Hand Driven Tricycle, abbreviated to trike is a three-wheeled passenger vehicle, usually carrying a single rider. The tricycle consists of a motorbike and an attached passenger sidecar and should not be confused with the tricycle. The trike is a motorized three-wheeled pedicab. Human-powered trikes are powered by pedals or hand cranks. Motorized trikes use motorcycle or scooter,or electric motors. Tricycles tend to be used for commercial purposes: such as "pedicabs" for transport passengers, and freight trikes for making deliveries. In the adult-sized tricycles are used primarily for recreation, shopping, and exercise. Tricycles are favoured by children and senior adults alike for their apparent stability versus a bicycle; but a conventional trike has poor dynamic lateral stability, and the rider must take care when cornering to avoid tipping the trike over. Standard Single Hand Driven Tricycle: Frame : Made by E.R.W. Tubes 22.22 mm- 18 G. Seat & Back : MS, CRC Sheet Seat Size 18"x 16" Wheel Size : Wheel Diameter 28"x 1 1/2" Tyre and Tube Standard Company. Parts : Standard Quality

"The more you eat in, the more you can control and the healthier your plate is going to be," says Rachel Brandeis of the American Dietetic Association. "I wish people would think that when they are eating, they could be lowering their cancer risk." Read the full article...

A tricycle for special needs is made so can go along for the ride in wheelchair or sitting in a special seat, both of which are attached right in front of another adult's trike. Tricycles to accommodate a vast array of special needs. Hand-pedaled recumbent tricycles are available for those without the use of their legs. Children, teens and adults with cerebral palsy and similar disorders can select tricycles specially designed to increase strength and coordination. Caregivers to autistic children can ride with their child on tandem special needs tricycles built to accommodate one adult and one child rider. Accessories are also available to convert standard trikes to suit specific needs. The objective of tricycle design is to produce wheelchairs that perform well and can provide appropriate seating and postural support without compromising strength, durability and safety. A Hand Driven Tricycle, abbreviated to trike is a three-wheeled passenger vehicle, usually carrying a single rider. The tricycle consists of a motorbike and an attached passenger sidecar and should not be confused with the tricycle. The trike is a motorized three-wheeled pedicab. Human-powered trikes are powered by pedals or hand cranks. Motorized trikes use motorcycle or scooter,or electric motors. Tricycles tend to be used for commercial purposes: such as "pedicabs" for transport passengers, and freight trikes for making deliveries. In the adult-sized tricycles are used primarily for recreation, shopping, and exercise. Tricycles are favoured by children and senior adults alike for their apparent stability versus a bicycle; but a conventional trike has poor dynamic lateral stability, and the rider must take care when cornering to avoid tipping the trike over. Standard Single Hand Driven Tricycle: Frame : Made by E.R.W. Tubes 22.22 mm- 18 G. Seat & Back : MS, CRC Sheet Seat Size 18"x 16" Wheel Size : Wheel Diameter 28"x 1 1/2" Tyre and Tube Standard Company. Parts : Standard Quality

A tricycle for special needs is made so can go along for the ride in wheelchair or sitting in a special seat, both of which are attached right in front of another adult's trike. Tricycles to accommodate a vast array of special needs. Hand-pedaled recumbent tricycles are available for those without the use of their legs. Children, teens and adults with cerebral palsy and similar disorders can select tricycles specially designed to increase strength and coordination. Caregivers to autistic children can ride with their child on tandem special needs tricycles built to accommodate one adult and one child rider. Accessories are also available to convert standard trikes to suit specific needs. The objective of tricycle design is to produce wheelchairs that perform well and can provide appropriate seating and postural support without compromising strength, durability and safety. A Hand Driven Tricycle, abbreviated to trike is a three-wheeled passenger vehicle, usually carrying a single rider. The tricycle consists of a motorbike and an attached passenger sidecar and should not be confused with the tricycle. The trike is a motorized three-wheeled pedicab. Human-powered trikes are powered by pedals or hand cranks. Motorized trikes use motorcycle or scooter,or electric motors. Tricycles tend to be used for commercial purposes: such as "pedicabs" for transport passengers, and freight trikes for making deliveries. In the adult-sized tricycles are used primarily for recreation, shopping, and exercise. Tricycles are favoured by children and senior adults alike for their apparent stability versus a bicycle; but a conventional trike has poor dynamic lateral stability, and the rider must take care when cornering to avoid tipping the trike over. Standard Single Hand Driven Tricycle: Frame : Made by E.R.W. Tubes 22.22 mm- 18 G. Seat & Back : MS, CRC Sheet Seat Size 18"x 16" Wheel Size : Wheel Diameter 28"x 1 1/2" Tyre and Tube Standard Company. Parts : Standard Quality

Cervix is the lower part of the uterus,that communicates with the vagina.A part of the cervix protrudes withn the vagina

A tricycle for special needs is made so can go along for the ride in wheelchair or sitting in a special seat, both of which are attached right in front of another adult's trike. Tricycles to accommodate a vast array of special needs. Hand-pedaled recumbent tricycles are available for those without the use of their legs. Children, teens and adults with cerebral palsy and similar disorders can select tricycles specially designed to increase strength and coordination. Caregivers to autistic children can ride with their child on tandem special needs tricycles built to accommodate one adult and one child rider. Accessories are also available to convert standard trikes to suit specific needs. The objective of tricycle design is to produce wheelchairs that perform well and can provide appropriate seating and postural support without compromising strength, durability and safety. A Hand Driven Tricycle, abbreviated to trike is a three-wheeled passenger vehicle, usually carrying a single rider. The tricycle consists of a motorbike and an attached passenger sidecar and should not be confused with the tricycle. The trike is a motorized three-wheeled pedicab. Human-powered trikes are powered by pedals or hand cranks. Motorized trikes use motorcycle or scooter,or electric motors. Tricycles tend to be used for commercial purposes: such as "pedicabs" for transport passengers, and freight trikes for making deliveries. In the adult-sized tricycles are used primarily for recreation, shopping, and exercise. Tricycles are favoured by children and senior adults alike for their apparent stability versus a bicycle; but a conventional trike has poor dynamic lateral stability, and the rider must take care when cornering to avoid tipping the trike over. Standard Single Hand Driven Tricycle: Frame : Made by E.R.W. Tubes 22.22 mm- 18 G. Seat & Back : MS, CRC Sheet Seat Size 18"x 16" Wheel Size : Wheel Diameter 28"x 1 1/2" Tyre and Tube Standard Company. Parts : Standard Quality

Colon cancer is the cancer of the lower part of the digestive system called the large Intestine or Colon & Balanced Diet and Regular Exercise Curtails Colon Cancer

Colon cancer is the cancer of the lower part of the digestive system called the large Intestine or Colon & Balanced Diet and Regular Exercise Curtails Colon Cancer

New data on weight loss drugs that could compete with Novo Nordisk's Wegovy are raising expectations there will soon be more options, and possibly lower prices, in an estimated $100 billion marketplace, doctors and pharmaceutical executives say. Drugmakers are ratcheting up their research and aiming for new formulations that can be taken as pills, options to deliver higher weight loss or drugs that reduce fat while maintaining muscle. "It has really been an explosion of innovation," said Dr. Robert Gabbay, chief science officer at the American Diabetes Association (ADA), which receives funding from both Novo and Eli Lilly and Co and just concluded its annual meeting in San Diego, California. "If there are multiple (treatments) in the market, that will lead to some level of competition and greater access."

Covid-19 vaccine maker Novavax on Wednesday said it expects revenue this year to be flat or lower as it works to improve its commercial performance and pick up market share from much larger rivals, Pfizer and Moderna. The company posted a larger-than-expected fourth-quarter loss as revenue lagged analysts' estimates. Chief executive John Jacobs said Novavax claimed just a low-single-digit percentage market share in the US during the most recent vaccination campaign, as demand for Covid vaccines was smaller than hoped and the company got its protein-based shot to market later than its messenger RNA-based rivals. "We were disappointed with that US performance," Jacobs said in an interview. He said the company's sales force was not targeted enough toward retail pharmacy chains, and that its 5-dose vials were not as convenient for use as rivals' pre-filled syringes.

...Do not take steroids. Steroids have been proven to interrupt the body's ability to produce natural hormones. Steroids can also have a negative effect on your liver, as well as lowering "good" cholesterol, and often causes men to develop some breast tissue... Enhance Your Body With These Bodybuilding Tips

The main causes of the lower muscle back pain are mainly two. One is due to the muscle imbalance and the other is the joint imbalance.

Arthritis is usually common when you reach 45. The thing that a lot of people don't understand in relation to arthritis tends to be that fast diagnosis of the condition can insure much lowered severity in later years.

Precor EFX 556 Elliptical Crosstrainer is a premium and gym quality fitness equipment is designed with the intent to protect your knees, hips and lower back.

Vissco Elastic Tubular Anklet Having an ankle injury or sprain can really render you immobile. The Vissco Elastic Tubular anklet provides compression, warmth and increase blood flow offering optimal support to the ankle joint. It is a seamless product with an open toe and open heel that ensure movement stays easy. It is made from skin friendly material and has a ventilating effect as the cotton knitted elastic releases sweat making the support breathable. Treatment of ankle conditions and pain Working as a coordinated team, our orthopedic/sports medicine specialists, surgeons and physical therapists use the most highly advanced, innovative techniques available to correct damage and reduce pain in the complex ankle joint, customized to each patient's individual needs. Ranging from conservative to interventional surgery, these treatment options include: Ankle arthroscopy/arthroscopic surgery Brostrom procedure for recurrent ankle sprains/instability Decompression of ankle impingement Drilling cartilage injury (OCD of talus) Orthisis Physical therapy and rehabilitation Removal of loose bodies WHEN TO USE Ligament sprain Soft tissue injury Swelling of ankle joint Vissco Elastic Tubular Anklet Features Skin Friendly Easy Breathe Soft Support Anti-Fungal Vissco Elastic Tubular Knee Caps Muscle or Ligament strains can be really bothersome, especially at the knee joint. We often over-work our knees in strenuous physical activities and then suffer from inflammations or strains. You might want to pick up our elastic tubular knee cap. It provides compression, warmth and improves blood flow to the soft tissue areas surrounding the joint. Its lightweight, breathable and comfortable ensuring it's worn more often, thus improving its therapeutic results. The cotton knitted fabric releases sweat and permit airflow, which its ergonomic design ensures a two way stretch. CALF & KNEE Your knee is where your thigh-bone and shin-bone m