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AstraZeneca on Wednesday (April 5) said a combination of its cancer drugs Imfinzi and Lynparza met the main goal in a late-stage trial in patients with advanced ovarian cancer. The drugmaker said treatment with a combination of those drugs, along with chemotherapy and bevacizumab - the existing standard of care - improved progression-free survival in newly diagnosed patients with advanced ovarian cancer without certain mutations. Lynparza is jointly developed with U.S.-based Merck & Co as a treatment for breast cancer in early stage with certain mutations. Imfinzi alone, along with chemotherapy and bevacizumab, did not reach statistical significance in its interim analysis, the drugmaker added. Philipp Harter, director, Department of Gynaecology and Gynaecologic Oncology, Evangelische Kliniken Essen-Mitte, Germany and principal investigator for the trial, said: "DUO-O showcases the power of academia and industry collaboration in advancing new treatment combinations for patients with ovarian cancer. I'm grateful for the academic cooperative study groups and patients around the world that made this trial possible and look forward to sharing the results with the clinical community." Susan Galbraith, executive vice president, Oncology R&D, AstraZeneca, said: "While there has been significant progress for patients with advanced ovarian cancer, an unmet need still remains. These data from the DUO-O trial provide encouraging evidence for this this Lynparza and Imfinzi combination in patients without tumour BRCA mutations and reinforce our continued commitment to finding new treatment approaches for these patients. It will be important to understand the key secondary endpoints as well as data for relevant subgroups."

In a recent announcement the Medicines and Healthcare products Regulatory Agency (MHRA) unveiled its strategic approach to artificial intelligence (AI), as it sets out to embrace the transformative potential of AI in healthcare regulation. Building upon the Government's white paper 'A pro-innovation approach to AI regulation', released in 2023, the MHRA outlined five key strategic principles guiding its adoption of AI. These principles encompass safety, security, and robustness; appropriate transparency and explainability; fairness, accountability, and governance; and contestability and redress. A science-led organization, the MHRA was tasked with providing an independent view of its approach to AI in medicine and science, aligning with a government white paper. Recognising its role in UK's goal to be a science and tech leader by 2030, MHRA is tasked to evaluate AI's opportunities and risks across regulatory, public service, and evidence-based decision-making area.

American pharmaceutical giant Pfizer has received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) for its medication Etrasimod, marketed as Velsipity, used to treat people with moderately to severely active ulcerative colitis. Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in the lining of the large intestine (colon) and rectum. The approved recommended dose for Velsipity is one 2 mg tablet to be taken once daily. For the first three days, it is advised to take the medication with food, and subsequently, it can be taken daily either with or without food. According to the regulator, the approval of the medication is based on evidence from two clinical studies, which showed that 26 per cent of patients taking etrasimod achieved clinical remission after 12 weeks of treatment compared with 11 per cent of those receiving placebo. The studies included more than 740 patients aged 16 years and over for whom standard treatment or other treatments did not work well enough or could not be used.

The Competition and Markets Authority (CMA) has revoked its initial enforcement order imposed on Pharmacy2U Limited (Pharmacy2U) concerning the acquisition of Metabolic Healthcare Ltd (Lloyds Direct). In the revocation order issued on February 12, the regulator said its decision was "based on the evidence it has received in its assessment of the Merger to date." The CMA served an initial enforcement order under section 72(2) of the Enterprise Act 2002 on Pharmacy2U, P2U Holdings Limited, G Square Capital II L.P., G Square Healthcare Private Equity LLP (collectively, the Acquirer Group) and Lloyds Direct on 28 November 2023. It announced that it was considering "whether it is or may be the case that a relevant merger situation has been created and whether the creation of that situation has resulted or may be expected to result in a substantial lessening of competition in any market or markets in the United Kingdom (UK)."

In a collaborative effort to combat the escalating threat of antimicrobial resistance (AMR), UWE Bristol and Bedminster Pharmacy have secured grant funding from the UKRI Regional Innovation Fund (RIF) for a groundbreaking 4-month project. This initiative aims to revolutionise antimicrobial stewardship (AMS) practices at the community pharmacy level, addressing the pressing need for evidence-based approaches in tackling AMR. With antibiotic misuse contributing significantly to the rise of AMR, the project underscores the vital role of community pharmacies in promoting responsible antibiotic use. Mr Ade Williams, Superintendent Pharmacist at Bedminster Pharmacy, emphasised the significance of this endeavour, stating:

In the fast-evolving world of medicine, staying updated with the latest research trends is crucial for healthcare professionals and researchers alike. This helps ensure that patient care is based on the best available evidence and keeps professionals at the forefront of innovations and advancements. Here are six essential tips on how to stay informed about the latest medical research trends. 1. Utilize Trusted Sources The vast amount of information available online can be overwhelming, making it essential to discern credible sources from unreliable ones. Here are some strategies to help: Identify Reputable Journals and Databases: Publications like The New England Journal of Medicine, The Lancet, and JAMA are renowned for their rigorous peer-review processes. Databases like PubMed and Google Scholar are also excellent for accessing a wide range of scientific papers. Check for Peer-Reviewed Articles: Peer review ensures that research has been evaluated by experts in the field, enhancing its credibility. Look for Author Credentials: Research conducted by established experts in the field is more likely to be trustworthy. Evaluate Institutional Affiliations: Research from reputable institutions and organizations often signifies high-quality work.

Addiction is a complex and multifaceted condition that can significantly impact an individual's physical, emotional, and psychological well-being. Despite the strong desire to overcome addiction, many people struggle to achieve lasting recovery on their own. Professional help is crucial in addiction treatment because it offers specialized knowledge, comprehensive care, and evidence-based approaches tailored to each individual's needs. With the support of trained professionals, individuals are more likely to develop the skills and strategies necessary to achieve and maintain long-term sobriety. Understanding the Nature of Addiction Addiction is often misunderstood as merely a lack of willpower or moral failing. However, it is recognized by the medical community as a chronic disease that affects the brain's reward, motivation, and memory functions. These changes make it exceedingly challenging for individuals to control their substance use, even when facing adverse consequences. Through professional assessment, clinicians can identify the specific nature and extent of the addiction. This involves understanding the types of substances used, frequency, and the presence of co-occurring mental health conditions. Accurate diagnosis is essential for developing a tailored treatment plan that addresses all aspects of the individual's condition. The people behind https://healtreatmentcenters.com/resources/ note that there are many treatment centers and support groups available to help people with addiction. It takes the expertise of professionals to properly diagnose and treat addiction effectively.

Steve Rector is the CEO of Corizon Health. He was brought on board after a 2017 corporate reorganization resulted in new investors and a new board of directors, including - for the very first time - three independent board members and a significant decrease in corporate debt.