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The human brain has always loved the dopamine rush of notifications, in any form; recent research indicates the unpredictable but ubiquitous updates of Gmail or Twitter carry the same neurological effect as rocking a slot machine. While Internet use is "not addictive in the same way as pharmacological substances are," as cognitive scientist Tom Stafford noted in 2013, we continually chase those unpredictable payoffs on Facebook and Instagram in ways that tend to mirror gambling or sex addictions, even if "Internet addiction" writ large currently holds an ambiguous position in the Diagnostic and Statistical Manual of Mental Disorders.

For products whose fundamental business proposition is harnessing attention, building those so-called "compulsion loops" isn't an accident of technology—it's the whole point. Indeed, observers have argued since Parker's "human psychology" flub last year that Facebook has not just meticulously measured, but fundamentally altered human behavior, and nascent technology ventures emboldened by Facebook's world-changing success have sought to translate the behavioral tricks that psychologist B.F. Skinner applied to the gambling kiosk to every mobile app under the sun. "When a gambler feels favored by luck, dopamine is released," Natasha Schüll, author of Addiction by Design: Machine Gambling in Las Vegas, told the Guardian in March. All Facebook managed to do was find a way to miniaturize the captivating logic of the slot machine—with no cost to the user but their time and attention.

While the human brain is tremendously plastic, that doesn't mean Facebook is savagely rewiring the human brain. Indeed, the Facebook users in the Cal State–Fullerton study "showed greater activation of their amygdala and striatum, brain regions that are involved in impulsive behavior," as Live Science's Tia Ghose reported at the time. Ghose continued: "But unlike in the brains of cocaine addicts, for instance, the Facebook users showed no quieting of the brain systems responsible for inhibition in the prefrontal cortex." Facebook isn't fundamentally rewiring the structure of the human brain, but its ubiquity has the same relative effect by kicking our rewards centers into overdrive.

A common misconception is that these youths are choosing to engage in the commercial sex trade. But as recent advances in neuroimaging techniques help scientists unravel the myriad ways that trauma affects the brain, emerging evidence suggests that brain changes resulting from trauma could make young people more vulnerable to exploiters and less receptive to people trying to help. Rather than making a conscious decision to rebel, these kids are simply doing their best to survive, using the adaptive strategies that their brains developed in response to a perilous world.

Though the human brain is adaptable throughout life, adaptability is greatest during childhood, as the developing brain responds to the surrounding environment. Survival is the brain's top priority. Young people growing up in dangerous environments will develop brains that are highly responsive to threat cues. In particular, recent studies show that children who have experienced trauma exhibit drastic changes in their amygdala, an area of the brain wired to identify signs of danger.

Besides the amygdala, another brain region affected by trauma is the hippocampus, an area involved with contextual learning and memory. The hippocampus takes context into account, so that a person can appropriately respond to the same cues in different situations. For instance, most people would respond differently to hearing gunfire in a shooting range than they would to hearing gunfire in an airport.