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Bill Fulkerson

A prediction model of outcome of SARS-CoV-2 pneumonia based on laboratory findings - 0 views

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    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in thousands of deaths in the world. Information about prediction model of prognosis of SARS-CoV-2 infection is scarce. We used machine learning for processing laboratory findings of 110 patients with SARS-CoV-2 pneumonia (including 51 non-survivors and 59 discharged patients). The maximum relevance minimum redundancy (mRMR) algorithm and the least absolute shrinkage and selection operator logistic regression model were used for selection of laboratory features. Seven laboratory features selected in the model were: prothrombin activity, urea, white blood cell, interleukin-2 receptor, indirect bilirubin, myoglobin, and fibrinogen degradation products. The signature constructed using the seven features had 98% [93%, 100%] sensitivity and 91% [84%, 99%] specificity in predicting outcome of SARS-CoV-2 pneumonia. Thus it is feasible to establish an accurate prediction model of outcome of SARS-CoV-2 pneumonia based on laboratory findings.
Bill Fulkerson

Scientists work to shed light on Standard Model of particle physics - 0 views

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    As scientists await the highly anticipated initial results of the Muon g-2 experiment at the U.S. Department of Energy's (DOE) Fermi National Accelerator Laboratory, collaborating scientists from DOE's Argonne National Laboratory continue to employ and maintain the unique system that maps the magnetic field in the experiment with unprecedented precision.
Bill Fulkerson

Researchers report new approach to cultured meat - 0 views

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    Humans are largely omnivores, and meat has featured in the diets of most cultures. However, with the increasing population and pressure on the environment, traditional methods of meeting this fundamental food requirement are likely to fall short. Now, researchers at the University of Tokyo report innovative biofabrication of bovine muscle tissue in the laboratory that may help meet escalating future demands for dietary meat.
Bill Fulkerson

Scientists May Be Using the Wrong Cells to Study Covid-19 | WIRED - 0 views

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    BY NOW THERE'S little doubt about hydroxychloroquine: It doesn't work for treating Covid-19. But there's a bigger, more important lesson hidden in the story of its failure-a rarely-mentioned, but altogether crucial, error baked into the early research. The scientists who ran the first, promising laboratory experiments on the drug had used the wrong kind of cells: Instead of testing its effects on human lung cells, they relied on a supply of mass-produced, standardized cells made from a monkey's kidney. In the end, that poor decision made their findings more or less irrelevant to human health. Worse, it's possible that further research into novel Covid-19 cures will end up being compromised by the same mistake.
Bill Fulkerson

Full article: Re-assembling the surveillable refugee body in the era of data-craving - 0 views

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    This article traces the travel of biometric data of Syrian refugees in Jordan through a hastily evolving political economy characterized by a pervasive craving for the extraction, storage and brokering of displacement data. It analyzes iris-enrollment as problematic acts of quasi-citizenship for the displaced requiring the performance of social and economic docility in order to attain identity, cash and service provision. Quasi-objects in the form of digital footprints are fashioned through infrastructures that simultaneously seek to model, yet fail to capture, socioeconomic existence in displacement contexts. Discourses of anti-fraud, donor dictates, upward accountability and strategies of financial inclusion of 'the unbanked', facilitate the marketization of the creation of data-doubles in laboratories of displacement and loopholes for externalization. Driven by increasingly blurred lines between technological, humanitarian and financial interests, this development has transformative effects on both those displaced, and on a humanitarian sector tasked with safeguarding their rights.
Bill Fulkerson

The health of ecosystems based on the ground beetle - 0 views

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    In a collaboration with Italian scientists as part of the European project Ecopotential, EPFL scientists built a model to predict the dynamics of two carabid species across the landscape of Gran Paradiso National Park in the Graian Alps, in Northern Italy, now combining field measurement with advanced remote sensing. The results are published in PNAS and the open-model is available on GitHub. "The main result of this work, which I deem important, is to suggest that an integrated ecohydrological framework blending field evidence, both theoretical and remotely acquired, has contributed substantially to our understanding of key indicators of ecological well-being, carabid beetles, in complex environments like iconic mountains," explains Andrea Rinaldo, who leads the Laboratory of Ecohydrology.
Bill Fulkerson

Lab-grown earthquakes reveal the frictional forces acting beneath our feet - 0 views

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    Simulating an earthquake on a miniature scale in a laboratory known unofficially as the "seismological wind tunnel," engineers and seismologists have produced the most comprehensive look to date at the complex physics of friction driving destructive thrust-fault earthquakes.
Steve Bosserman

Jane Jacobs's Theories on Urban Planning-and Democracy in America - The Atlantic - 0 views

  • Urban life was Jacobs’s great subject. But her great theme was the fragility of democracy—how difficult it is to maintain, how easily it can crumble. A city offered the perfect laboratory in which to study democracy’s intricate, interconnected gears and ballistics. “When we deal with cities,” she wrote in The Death and Life of Great American Cities (1961), “we are dealing with life at its most complex and intense.” When cities succeed, they represent the purest manifestation of democratic ideals: “Cities have the capability of providing something for everybody, only because, and only when, they are created by everybody.” When cities fail, they fail for the same reasons democracies fail: corruption, tyranny, homogenization, overspecialization, cultural drift and atrophy.
  • I was encouraged to believe that simple conformity results in stagnation for a society, and that American progress has been largely owing to the opportunity for experimentation, the leeway given initiative, and to a gusto and a freedom for chewing over odd ideas. I was taught that the American’s right to be a free individual, not at the mercy of the state, was hard-won and that its price was eternal vigilance, that I too would have to be vigilant.
  • Her 1,500-word speech, a version of which appears in Vital Little Plans, became the basis for The Death and Life of Great American Cities. Her main argument was Kirk’s: Small neighborhood stores, ignored by the planners in their grim demolition derby, were essential social hubs. She added that sidewalks, stoops, laundries, and mailbox areas were also indispensable centers of community activity, and that sterile, vacant outdoor space served nobody. “The least we can do,” she said, “is to respect—in the deepest sense—strips of chaos that have a weird wisdom of their own.”
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  • Reduced to a word, Jacobs’s argument is that a city, or neighborhood, or block, cannot succeed without diversity: diversity of residential and commercial use, racial and socioeconomic diversity, diversity of governing bodies (from local wards to state agencies), diverse modes of transportation, diversity of public and private institutional support, diversity of architectural style. Great numbers of people concentrated in relatively small areas should not be considered a health or safety hazard; they are the foundation of a healthy community. Dense, varied populations are “desirable,” Jacobs wrote,
  • Madison argued that as you increase the “variety of parties and interests” contained within a republic, “you make it less probable that a majority of the whole will have a common motive to invade the rights of other citizens.”
  • “We need all kinds of diversity,” Jacobs concluded in Death and Life, “so the people of cities can sustain (and further develop) their society and civilization.”
  • In her comparative study of fallen empires, Jacobs identifies common early indicators of decline: “cultural xenophobia,” “self-imposed isolation,” and “a shift from faith in logos, reason, with its future-oriented spirit … to mythos, meaning conservatism that looks backwards to fundamentalist beliefs for guidance and a worldview.” She warns of the profligate use of plausible denial in American politics, the idea that “a presentable image makes substance immaterial,” allowing political campaigns “to construct new reality.” She finds further evidence of our hardening cultural sclerosis in the rise of the prison-industrial complex, the prioritization of credentials over critical thinking in the educational system, low voter turnout, and the reluctance to develop renewable forms of energy in the face of global ecological collapse.
  • In the foreword to the 1992 Modern Library edition of Death and Life, Jacobs likens cities to natural ecosystems. “Both types of ecosystems,” she writes, “require much diversity to sustain themselves … and because of their complex interdependencies of components, both kinds of ecosystems are vulnerable and fragile, easily disrupted or destroyed.”
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