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We need to take a hard look at what parts of the world are critical to the security of the West and rethink how to make its alliances work again. The following geopolitical reality is still true today: The United States has to ensure that no power hostile to its interests can assert exclusive control over Eurasia, including the European rimland. Today preventing China's domination of Eurasia should be our overarching strategic objective, and to achieve this we need to focus on three fundamentals: 1) Prioritize Eurasia and stop draining our military resources in secondary theaters; 2) invest in allies who see their interests directly aligned with ours and are willing to assume the attendant risk; and 3) decouple U.S. strategic industries from China's and redefine the rules of international trade to ensure equitable competition.

The synthesis of structurally complex organic molecules is the first task in the discovery of functional compounds needed for new technologies, including those in medicine and flexible electronics. Starting with relatively simple, purchasable reactants, the process involves sequences of chemical reactions in which the complexity of the molecules produced gradually increases with each step towards the final target. The sequences can be linear, or convergent (different parts of the target molecule are made in separate sequences and then joined together). To ensure that large amounts of the final product are prepared, each synthetic step must be high-yielding and reproducible, and must generate few side products.