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Writing stimulates a bunch of cells at the base of the brain called the reticular activating system (RAS). The RAS acts as a filter for everything your brain needs to process, giving more importance to the stuff that you're actively focusing on at the moment—something that the physical act of writing brings to the forefront.

found that children's writing ability was consistently better (they wrote more, faster, and more complete sentences) when they used a pen rather than a keyboard;

As a compromise, perhaps we should all get stylus-friendly tablet PCs or digital pens.