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Matti Narkia

High Doses of Vitamin D Cut MS Relapses - 0 views

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    "April 28, 2009 (Seattle) -- High doses of vitamin D dramatically cut the relapse rate in people with multiple sclerosis, a study shows.

    Sixteen percent of 25 people with multiple sclerosis (MS) given an average of 14,000 international units (IU) of vitamin D a day for a year suffered relapses, says Jodie Burton, MD, a neurologist at the University of Toronto. In contrast, close to 40% of 24 MS patients who took an average of 1,000 IU a day -- the amount recommended by many MS specialists -- relapsed, she says.

    Also, people taking high-dose vitamin D suffered 41% fewer relapses than the year before the study began, compared with 17% of those taking typical doses.

    People taking high doses of vitamin D did not suffer any significant side effects, Burton tells WebMD."
Matti Narkia

Vitamin D and MS: Burton - 1 views

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    "Dr. Jodie Burton is the acting principal investigator (PI) of the dose-escalation trial of oral vitamin D3 with calcium supplementation in patients with multiple sclerosis with Dr. O'Connor. She started the trial as his fellow, while doing an additional 2 years of training in MS specifically after she received her neurology certification. She completed her fellowship training in 2007. Now she is staff doing clinical research and continuing with the vitamin D trial. As of August 2009, she will be Assistant Professor in Neurology in the Department of Clinical Neuroscience in Calgary and at the University of Calgary. She will be part of the MS team there with Dr. Luanne Metz and the MS group.

    Please scroll down for an abstract of the trial:
    A Phase I/II dose-escalation trial of oral vitamin D3 with calcium supplementation in patients with multiple sclerosis."

    Conclusions:
    High-dose VD3 (~10 000 IU/day, possibly higher) in MS is safe and tolerable, with evidence of clinical improvement.
Matti Narkia

Safety of vitamin D3 in adults with multiple sclerosis -- Kimball et al. 86 (3): 645 --... - 0 views

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    Safety of vitamin D3 in adults with multiple sclerosis.
    Kimball SM, Ursell MR, O'Connor P, Vieth R.
    Am J Clin Nutr. 2007 Sep;86(3):645-51.
    PMID: 17823429

    Conclusions: Patients' serum 25(OH)D concentrations reached twice the top of the physiologic range without eliciting hypercalcemia or hypercalciuria. The data support the feasibility of pharmacologic doses of vitamin D3 for clinical research, and they provide objective evidence that vitamin D intake beyond the current upper limit is safe by a large margin.
Matti Narkia

Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in... - 0 views

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    Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study.
    Djoussé L, Arnett DK, Carr JJ, Eckfeldt JH, Hopkins PN, Province MA, Ellison RC; Investigators of the NHLBI FHS.
    Circulation. 2005 Jun 7;111(22):2921-6. Epub 2005 May 31.
    PMID: 15927976
    doi: 10.1161/CIRCULATIONAHA.104.489534
Matti Narkia

The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Anal... - 0 views

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    Pittas AG, Lau J, Hu FB, Dawson-Hughes B.
    The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis.
    J Clin Endocrinol Metab. 2007 Jun;92(6):2017-29. Epub 2007 Mar 27. Review.
    PMID: 17389701 [PubMed - indexed for MEDL
Matti Narkia

Vitamin D and calcium supplementation reduces cancer risk: results of a randomized tria... - 0 views

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    Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP.
    Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial.
    Am J Clin Nutr. 2007 Jun;85(6):1586-91.
    PMID: 17556697 [PubMed - indexed for MEDLINE]
Matti Narkia

Calcium and Vitamin D Intake and Risk of Colorectal Cancer: The Multiethnic Cohort Stud... - 0 views

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    Park SY, Murphy SP, Wilkens LR, Nomura AM, Henderson BE, Kolonel LN.
    Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study.
    Am J Epidemiol. 2007 Apr 1;165(7):784-93. Epub 2007 Jan 10.
    PMID: 17215380 [PubMed - indexed
Matti Narkia

The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of In... - 0 views

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    Pittas AG, Harris SS, Stark PC, Dawson-Hughes B.
    The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults.
    Diabetes Care. 2007 Apr;30(4):980-6. Epub 2007 Feb 2.
    PMID: 17277040 [PubMed - in
Matti Narkia

Long-latency deficiency disease: insights from calcium and vitamin D -- Heaney 78 (5): ... - 0 views

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    Heaney RP.
    Long-latency deficiency disease: insights from calcium and vitamin D.
    Am J Clin Nutr. 2003 Nov;78(5):912-9. Review.
    PMID: 14594776 [PubMed - indexed for MEDLINE]
Matti Narkia

Does nutritional intake differ between children with autism spectrum disorders and chil... - 0 views

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    Does nutritional intake differ between children with autism spectrum disorders and children with typical development?
    Herndon AC, Diguiseppi C, Johnson SL, Leiferman J, Reynolds A.
    J Autism Dev Disord. 2009 Feb;39(2):212-22. Epub 2008 Jul 4.
    PMID: 18600441
    DOI: 10.1007/s10803-008-0606-2
Matti Narkia

Vitamin D deficiency an important, common, and easily treatable cardiovascular risk fac... - 0 views

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    Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?\nLee JH, O'Keefe JH, Bell D, Hensrud DD, Holick MF.\nJ Am Coll Cardiol. 2008 Dec 9;52(24):1949-56. Review.\nPMID: 19055985
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