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Rosa Medina

NIMH · Mapping the Risk Architecture of Mental Disorders - 0 views

www.nimh.nih.gov/...ture-of-mental-disorders.shtml

twitter enfermedad mental datificación pacientes HEM

shared by Rosa Medina on 08 Aug 14 - No Cached
  • The history of psychiatric genomics has been, until recently, disappointing
  • led to many papers but few replications and no actionable findings
  • Over the past five years, as the field realized the need for larger numbers of samples, investigators from around the world have worked together to share results in the hope of attaining the statistical power needed to find variants associated with schizophrenia or autism
  • ...14 more annotations...
  • the Psychiatric Genomics Consortium
  • Most of these are not in or even near genes. And any one of these 108 regions contributes only a tiny fraction of risk in the population. Nevertheless, this is a major step forward in describing the genetic risk for schizophrenia
  • what makes this such an exciting study
  • confirming that some regions are worth a deeper dive
  • the question of how many other loci might contain targets for medications yet to be developed
  • to stratify individuals for vulnerability to schizophrenia
    • Rosa Medina
      Rosa Medina on 08 Aug 14
       
      Estratficar a la gente en función del riesgo ?? ESTRATIFICAR??
  • common variation
  • rare variants have been spontaneous or de novo changes in the genome and some have a considerable impact on risk
    • Rosa Medina
      Rosa Medina on 08 Aug 14
       
      COMMON VARAITION VS RARE VARIANTS
  • he precise components of this risk need to be determined in other studies, but the new picture suggests
    • Rosa Medina
      Rosa Medina on 08 Aug 14
       
      Vamoa que hay alteraciones pero que no encuentran un patrón común que vincule una enfermedad a una alteración específica
  • complex genetic disorders, disorders in which scores or hundreds of variants, both common and rare, contribute to risk
  • the molecular pathways of risk
  • r translational science
    • Rosa Medina
      Rosa Medina on 08 Aug 14
       
      TRANSLATIONAL SCIENCE se refiere a interdisciplinariedad a comunicar NEUROCIENCIAS Y GENÉTICA ???
  • Rosa Medina on 08 Aug 14
     
    Mapping the Risk Architecture of Mental Disorders http://t.co/qYW9Dl3UTe
Rosa Medina

Del libro Banking the body - 0 views

Del libro Banking the body http://www.geneticsandsociety.org/article.php?id=7952 “Si el pensar no barre la casa por dentro, no es pensar” (María Zambrano) Begin forwarded messa...

HEM biobancos cuerpo datificación

started by Rosa Medina on 08 Aug 14 no follow-up yet
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