Lycopene Tomato Extract Lycopene is a non-provitamin A carotenoid that is fat-soluble and is responsible for the red coloration of certain fruits such as tomatoes, guavas, watermelons, and pink grapes. Since animals and humans cannot synthesize lycopene, they must rely on dietary intake to obtain this important carotenoid. Lycopen is the major carotenoid present in Human serum and approximately 50% of total carotenoids in the prostate gland and up to 60% in the testes.