more people living in cities, people moving frequently, and changing climate.[2] The disease originated in Africa, where it spread to South America through the slave trade in the 17th century.[1] Since the 17th century, several major outbreaks of the disease have occurred in the Americas, Africa, and Europe.[1] In the 18th and 19th centuries, yellow fever was seen as one of the most dangerous infectious diseases.[1] The yellow fever virus was