chronic health

Curcumin-treated biofilms displayed significantly reduced metabolic activity and no visible extracellular matrix. Although the previous study investigated the effects of curcumin on matured biofilms, the current study investigates the effect of curcumin on the early as well as the late stages of biofilm formed by P. gingivalis with S. mutans and A. viscosus, mimicking the in vivo condition of biofilm associated lesion of periodontitis. We observed when all the three bacteria were grown concurrently and then the drug was administered, the effect of the drug was maximum, and at 8.913 μM concentration, biofilm was completely suppressed within 90 min

For instance, extracts from E. globules leaf, exhibited the antibacterial activity with MIC values of 1–10 μg ml−1 against P. gingivalis and T. denticola, and was found to inhibit P. gingivalis Arg- and Lys-specific proteinase activities at 50–100 μg ml−1.55

Similarly, another controlled study showed that chewing gum containing eucalyptus extracts significantly inhibited the plaque formation and gingival inflammation.

The mean gingival index was 0.91 and the plaque index was 1.19 at baseline. In comparison to the baseline values both the gingival and the plaque indices substantially reduced during the period of assessment. There was a steady decline in both the plaque index and the gingival index values from day 7. The average gingival index score on day 30 was down to 0.401 and the plaque index score was 0.385 [Figures ​[Figures11 and ​and2].2]. Statistical analysis using the paired t test showed that the decrease was statistically significant [Tables ​[Tables22 and ​and33].