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Study will provide information about changes that occur in the motor neurons of the spinal cord (the nerve cells that control the muscles) when the motor cortex (the region of the brain that controls movement) is unable to send messages to the spinal cord and muscles in the normal way. This information will help elucidate how the nervous system adapts after injury or disease of the motor cortex.

Shriners Hospitals for Children study proposes to determine if injections of BTX-A to the hamstring muscles result in measurable physiologic changes not observed with normal saline injections in children with spastic diplegic cerebral palsy who walk with a flexed-knee gait pattern.

Study being conducted to better understand how the brain controls movement, to learn more about movement disorders and to train movement disorder specialists.

Study to improve understanding of the pathophysiology of movement disorders by performing small behavioral, electrophysiological and neuroimaging substudies. This will allow identifying dysfunction of the central nervous system that causes behavioral abnormalities seen in movement disorder patients.