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Observational cohort study designed to identify the mechanisms of disease in patients with preterm labor/contractions and preterm premature rupture of membranes and to describe the relationship between clinical, biochemical, histological, biophysical parameters and the development of infant neurological disorders.

Proposed study is designed to evaluate patients at particular risk for preterm delivery; those with advanced cervical exam. In this randomized prospective controlled study, we intend to examine the influence of adjunctive antibiotic use in preterm labor complicated by a cervical exam of 4 cm or greater. Comparison will be made between a study group receiving broad-spectrum antibiotics with a control group that will not receive antibiotics for pregnancy prolongation

NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development - NIH News - Common Treatment to Delay Labor Decreases Preterm Infants' Risk for Cerebral Palsy, August 2008

NICHD Center for Developmental Biology & Perinatal Medicine (CDBPM). The CDBPM supports scientists who are advancing fundamental and clinical knowledge about maternal health and problems of child development, including preterm labor and birth, intellectual and developmental disabilities, congenital and genetic disorders, fetal growth restriction, and other conditions. The Center and its programs aim to maximize human development, prevent diseases and disorders, and improve diagnoses, therapy, and clinical care.