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The Merck Manuals Online Medical Library - Information and causes of birth injury

Completed study. In this feasibility study, hyperoxemia, as proximated by transcutaneous hemoglobin saturation with oxygen (Sp02), at the time of birth will cause sustained pulmonary oxidative stress as demonstrated by elevation of ulmonary protein carbonyl. Furthermore, this oxidative stress will be directly proportional to the imposed oxygen-burden during resuscitation at the time of birth. This study will give us information regarding the magnitude of protein carbonyl elevation in the preterm infant. With these results we will be able to 1. establish the technique for the running or protein carbonyl assays and 2. calculate an appropriate sample size for a future randomized control trial.

Acute birth asphyxia is a cause of death and neurological injury. At present, there is no proven treatment; however, studies in animals suggest that brain cooling may protect against brain injury. This large multicenter trial will randomize term infants with a history of problems at delivery and signs of depression to total body cooling or standard care.

PubMed absact of a retrospective review of cases, the causes of cerebral palsy in 142 children living in the northwestern United States and born after Jan 1, 1970, were prenatal in 50% of the cases, similar to findings recently reported from Sweden

WebMD - Cerebral Palsy - Topic Overview