Drugs cause liver becomes weakened - 2 views
started by game gautruc on 23 Jun 15
started by game gautruc on 23 Jun 15
started by game gautruc on 23 Jun 15
started by game gautruc on 23 Jun 15
Medications such as isoniazid, rifampicin, streptomycin ..., especially isoniazid (INH). From the mid-20th century, INH is the main treatment for tuberculosis. The liver enzyme elevations appear several weeks after starting TB treatment is about 10-20% of patients taking INH. The liver enzyme elevations are generally moderate and not related signs or symptoms of liver disease. In many patients with elevated liver enzymes continue taking INH still can tolerate and then liver enzymes returned to near normal. If you have elevated liver enzymes, liver enzymes discontinued INH then returns to normal within 1-4 weeks. However there are fewer patients taking INH can acute liver failure (which can occur in about 0.1 to 2% of patients). Patients older than 50 years are more at risk for hepatitis while taking INH, children rarely have liver damage occurs. Female patients are affected more than men. When treatment should be closely monitored to detect hepatitis treatment by INH to stop in time and avoid heavy impact on the liver.
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Vitamin A
Drinking too much vitamin A causes liver toxicity depending on the dosage can lead to cirrhosis. Drinking large amounts of vitamin A frequent (> 25,000 units / day) can cause chronic poisoning and liver damage. Liver damage can occur when taken 15000-40000 units / day in a year, but higher doses may be poisoning within a few months. Liver damage more or less depending dosage and duration of use. Many patients with liver disease caused by vitamin A might not notice, just as clinicians see patients phenomenon prolonged vitamin A fat associated hepatitis, increased portal pressure is discovered . Alcoholics higher risk.
Several other drug groups
Also, some types of drugs can cause liver damage like fungus treatment (nystatin, ketoconazole, fuconazole), anti-thyroid drugs (PTU, MTU), antidiabetic drugs (sulphonamides, troglitazone, rosiglitazole) , cardiovascular medications (amiodazon, methyldopa, quinidine), anticonvulsants (phenytoin, carbamazepine) ...
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Besides the side effects of medications, we also note several factors that can increase the toxicity of the drug to the liver that is alcohol (alcohol can increase the toxicity of the drug to the liver most of which have to mention paracetamol , isoniazid); have liver disease before (such as chronic hepatitis, cirrhosis, ...); dosage of medication (some medication at a low dose is safe but use at high doses or overdoses cause for liver toxicity); the interaction between the drug increases the likelihood of liver toxicity (the isoniazid and rifampicin combination will increase the toxicity of rifampicin with liver).
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Therefore, to secure the drug, patients need utmost compliance guidelines, medical doctor's orders, not to abuse drugs and voluntarily taking medication, medication that can manifest as anorexia fear fat, dark urine, liver area pain, ie, the need to right the medical establishment to be inspected detected and treated promptly.