Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.
Kidd P.
Altern Med Rev. 2003 Aug;8(3):223-46. Review.
PMID: 12946237
Th1 pathways typically produce activation
of cytotoxic T lymphocytes (Tc), NK cells,
macrophages, and monocytes, all of which can
attack cancer cells and generally defend against
tumors.55 IFN-gamma and other Th1 cytokines are
typically lower in advanced cancer patients, while
the Th2 marker IL-4 can be higher or unchanged
Molecular immunological approaches to biotherapy of human cancers--a review, hypothesis and implications.
Becker Y.
Anticancer Res. 2006 Mar-Apr;26(2A):1113-34. Review.
PMID: 16619514
Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients.
Wei H, Sun R, Xiao W, Feng J, Zhen C, Xu X, Tian Z.
Oncol Rep. 2003 Sep-Oct;10(5):1507-12.
PMID: 12883732