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ESR Vial Determination of the Erythrocyte Sedimentation Rate for fully automated analyzers. ESR is a clinical lab test that measures the rate at which red blood cells in whole blood descend into a standardized tube, reported as mm per hour, to measure inflammation as inflamed red blood cells settle quickly relative to normal blood cells. A high ESR could be indicative of elevated inflammation. ESR blood test vacutainer is one kind of whole blood collection tube.