I really like the limitation of scope to 'information artifact'. This is also the way I had started to remodel the sequence ontology. 'DNA sequence information' as stored in GenBank is an information artifact. This information 'is about' the physical primary structure of a DNA molecule. The fact that DNA molecules can be transcribed (biologically) to produce RNA molecules by the molecular machinery of a cell does not require humans to be around. Doing this gets rid of the current confusion in SO between things that happen with physical DNA, and things I can do with DNA information in my computer (gapped sequences, BLAST alignments, phylogenetic trees, etc.). - Bjoern