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Zinc finger, as a miniprotein composed of 26 amino acids, was firstly identified in a transcription study via Xenopus laevis (African clawed frog) and characterized by the coordination of one or more zinc ions in order to stabilize the fold. These proteins are now found with various binding properties which can also bind to DNA, RNA, protein or lipid substrates. Zinc finger is a member of the DNA-binding motifs family, contains multiple finger-like protrusions that can recognize a diverse set of DNA strings in a sequence-specific manner. The binding ability of zinc finger is considered to involve the sequences of finger domains and their linkers, as well as their number and structure order.

On July 1st, Creative Biolabs announced custom scaffold library construction services for Monobody, Adnectin, FN3 or the fibronectin type III domain. Its innovative technology enables the generation of scaffold libraries with desired diversity and high controllability. Scientists of Creative BIolabs developed HiAffi™ platform, which provides an easy and reliable way to build up scaffold libraries and to select potential candidates for use in R&D applications, drug discovery and the development of diagnostic kits. It can be regarded as the foundation of this update service. Read full article at http://www.merchantcircle.com/blogs/Creative.Biolabs.63-187-1580/2015/7/Custom-Scaffold-Library-Construction-Service-in-Research-Applications/1272792.