In addition to adopting online learning as what we call a sustaining innovation, avoiding disruption will require incumbent institutions to effectively change their DNA. Most will need to become more focused on undergraduate students, cutting back on graduate programs that serve relatively few students while consuming much faculty time and generating little of the prestige hoped for when they were created. Programmatic offerings need to be more focused: Some majors should be dropped, and many should be shortened, making it more feasible for students to complete a degree in four years. The number of departments and centers at most institutions needs strategic shrinking.