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Nicholas Scholz

The effects of the brain in reproduction - 1 views

  • Properly functioning FSH (Follicle Stimulating Hormone) is needed to ensure fertility
  • Recently, the group of researchers at the University of Muenster (Germany) has analysed genetic variants in both the FSH gene and in the FSH receptor, which affect fertility in both males and females.
  • The group found that a distinct single nucleotide change in the DNA structure of FSHB gene (the FSH molecule has 2 subunits -- FSHB is the B subunit) caused significant effects in the functioning of the hormone in both men and women
  • ...3 more annotations...
  • They found that males with the FSHB variation had significant drops in FSH levels and in testicular volume
  • However, the number of women with the combined variation so far studied was not high enough to draw significant conclusions.
  • We estimate that around 45% of infertile men would respond to FSH therapy
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    Reproduction is obviously a vital aspect of the human development. With a non-functioning fertility system future generations would be at a loss. Many problems could arise with infertility and ground-breaking research is finally being conducted. One of the important aspects of human reproduction is the use of hormones specifically FSH (Follicle Stimulating Hormone). This hormone is produced at the base of the brain stem and non-existing levels of FSH were recently associated with infertility. In order to regenerate these hormones a change has to be made in the FSHB subunit of the nucleotide. Infertility usually occurs after certain changes are made in the hormone levels and by redirecting the levels of hormones we may be able to alter the problems that arise during reproduction. It should also be noted that increases and decreases in the levels of FSH may have different effects depending on the gender of the patient. Current research estimates that the response of males to this therapy could positively effect nearly 45% of infertile men. Estimates could not be made for females as a result of insufficient research. 
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