Argument: R S Downie argues that medicine and literate interact in many ways, and how literature has affected medicine and how medicine has affected. Downie addresses the 4 main types of connection between literature and medicine: (1) insights into medicine, from doctors who have become writers, (2) plays, films, novels that have medical settings, (3) the treatment on doctors and nurses by non-medical writers, and (4) the illumination of the patient doctor relationships. Claims: Picoult reveals the two of the 4 main medical and literature connections in both of her novels that I read. She incorporates medicine into both novel settings and reveals some doctor patient relationships. Evidence: "many plays, films, novels or TV serials have a medical setting. The appeal of this from the dramatic point of view is obvious: emotion" (Downie). "'whole person' approach to the doctor-patient relationship, and the 'whole person' approach is regarded by many doctors as distinctive of enlightened patient care" (Downie).

Argument: Narration to medical ethics comes in two forms: the use of stories for their content and methods of analysis. Claims: Picoult uses both forms of narration in medical ethics in her two books, "My Sisters Keeper" and "Handle With Care". She uses multiple narration in "My Sisters Keeper" to develop the story of ethical issues for Anna and the analysis of the daughters medical condition and ethical issues presented from the mother in "Handle With Care". Evidence: "The contributions of narrative to medical ethics come primarily in two ways: firstly, from the use of stories (narratives) for their mimetic content-that is, for what they say; and secondly, from the methods of literary criticism and narrative theory for their analysis of diegetic form-that is, for their understanding of how stories are told and why it matters." "During the past two decades, stories have been important to medical ethics in at least three major ways: firstly, as case examples for the teaching of principle based professional ethics, which has been the dominant form of medical ethics in the Western world; secondly, as moral guides to living a good life, not just in the practice of medicine but in all aspects of one's life; and thirdly, as narratives of witness that, with their experiential truth and passion, compel re-examination of accepted medical practices and ethical precepts." "In the past decade, scholars have begun to use the methods of literary criticism and narrative theory to examine the texts and practices of traditional medical ethics. What are now referred to as narrative approaches to medical ethics, or narrative contributions to medical ethics, use techniques of literary analysis to enhance the practice of principle based medical ethics. In contrast, what has become known as narrative ethics has reconceptualised the practice of medical ethics, seeking to replace principlism with a paradigmatically different practice."

Argument: Helena Silva, in her literary criticism of "My Sisters Keeper" argues that the advancements in biotechnology and genetic research are raising ethical questions of scope and the limits of genetic intervention. Claim: Silva argues that the advances in biotechnology and genetic research presented in Picoult's "My Sisters Keeper" are allowing doctors to intervene in the human genome preventing diseases. This intervention is raising concerns in the scientific community that might soon be able to take biological evolution into its own hands. Almost "playing God" in a sense. Evidence: "Playing God" is an expression commonly used to refer to this self-transformation of the species which, from the evidence, might soon be a reality" (Silva). "Jodi Picoult, an American novelist has been devoting her writings to several present-day events and controversial issues such as genetic engineering and the prospect of "savior siblings" with all its ethical implications" (Silva). "Anna wasconceived for a specific purpose and can't be forgotten because she is expected always to be ready for the welfare of her sister" (Silva).