Skip to main content

Home/ Groups/ Aging report
Danila Medvedev

genome.gov | A Brief History of the Human Genome Project - 0 views

  •  
    общая история проекта
Danila Medvedev

BBC News | ISS | ISS timeline - 0 views

  •  
    краткий таймлайн проекта.
Danila Medvedev

International Space Station - Wikipedia, the free encyclopedia - 0 views

  • With origins in the Cold War, the International Space Station represents a union of several space station projects from various nations.
    • Danila Medvedev
       
      Описание того, как непросто развивалась и продвигалась эта идея.
  • As a multinational project, the legal and financial aspects of the ISS are complex. Issues of concern include the ownership of modules, station utilisation by participating nations, and responsibilities for station resupply. The main legal document establishing obligations and rights between the ISS partners is the Space Station Intergovernmental Agreement (IGA).
  • The most cited figure of an overall cost estimate for the ISS ranges from 35 billion to 100 billion USD.[73] ESA, the only agency actually stating potential overall costs, estimates €100 billion for the entire station over a period of 30 years.
  •  
    Общий обзор об МКС, где есть ряд важных кусков.
Danila Medvedev

Microfunding of Early-Stage Scientific Research - 0 views

  • Similarly, many people could fund the answer to an important piece of scientific research if they so desired. Biotechnology is cheap nowadays, and only getting cheaper as time advances. The range of $5-20,000 will buy you a postgrad who knows what he's doing and lab access for long enough to answer an interesting question or produce a proof of principle - roughly the same as "is this worth chasing any further?" Can you use lasers to destroy lipofuscin inside cells, for example
  • The web of relationships, technology, and eager passage of information that enables a dynamic start-up culture is lacking for early stage research. A yawning gulf separates research communities from the many purses that might be opened were the connection made. People donate to research via intermediary organizations with broad goals because there is no readily available, widely understood way to do anything else.
  •  
    финансирование научных микро-проектов на начальном этапе.
Danila Medvedev

Organizational Profile by JAAM of the GRG in December 2003 - 0 views

  • Stephen Coles, M.D., Ph.D., is the Director and a co-founder of the Gerontology Research Group in Los Angeles. He is a stem-cell researcher in the Department of Surgery at the UCLA Geffen School of Medicine. In addition, he has organized a lecture series in gerontology for the past 12 years.
  • Dr. Steven Kaye, M.D., and I co-founded the GRG during the spring of 1990. We met once a month for about six months in each other’s homes and along the way wrote a Charter, or Mission Statement, for the group, describing what we wanted to see done in our lifetimes in the field of Anti-Aging Medicine.
  • in January of 1991, was our first formal lecture, and since then we have had at least one lecture per month for the past 12 years (including Summers) — 154 lectures and still going strong! In retrospect, our presenters have included world-famous researchers in gerontology. We videotaped each lecture and now have an extensive library of VHS tapes.
  • ...2 more annotations...
  • For any given lecture, 15 to 20 persons typically attend. About half the lectures are clinical in nature, while the other half focus on the basic sciences (or sometimes on engineering instrumentation), in which we talk about the chemistry and physics of molecular processes in the body. About half of our members are Ph.D.’s and about a quarter are M.D.’s.
  •   Today, the Los Angeles Gerontology Research Group consists of about 160 members: we have also founded Chapters in other cities, such as Washington, D.C. and New York City. About six years ago, we established a website (www.grg.org)
  •  
    Геронтологическая исследовательская группа
Danila Medvedev

Milestone (1971): President Nixon declares war on cancer - 0 views

  •  
    Краткие факты о начале и положительная оценка войны против рака прошлым директором NCI.
Danila Medvedev

Мы начали войну против рака... И рак победил. - 0 views

  •  
    После миллиардов израсходованных на научные исследования и десятилетия попыток лечения, пора переосмыслить войну против рака.
viktor zykov

В миллиард евро обойдется спасение Голландии от затопления | Водные технологи... - 0 views

  •  
    Мегапроекты
viktor zykov

Мировой океан затопит Голландию - 1 views

  •  
    Мегапроекты
viktor zykov

создание городов - 0 views

  •  
    Города Будущего
viktor zykov

о мегапроектах - 0 views

  •  
    Форум в Якутии
viktor zykov

Новости по мегапроектам - 0 views

  •  
    немного
viktor zykov

Голландская морская защита - 0 views

  •  
    Голландия
viktor zykov

Российские мегапроекты (инфраструктурные) - 0 views

  •  
    Презентация
Danila Medvedev

Научные мегапроекты (Китай) - 0 views

  •  
    Информация о китайских мегапроектах (2004 г.)
Danila Medvedev

Bent Flyvbjerg - 0 views

  •  
    Эксперт по крупным проектам, автор нескольких книг и множества статей. BT Professor and Chair of Major Programme Management
Danila Medvedev

Pharmaceuticals and Aging - Interview with Dr. Larry Miller (SAGE CROSSROADS ) - 0 views

  • Dr. Miller formerly led business operations for the global Drug Discovery Division at pharmaceutical company Glaxo Smith Kline.
  • Well one thing that I think is going to be critical is that in the past, pharmaceutical companies had treated diseases of aging as discrete entities, that is to develop something for diabetes, to develop something for osteoporosis…that is to treat each one as a separate silo if you will.
  • in the future we are going to have to look at more central regulatory pathways that are being identified now for aging.
  • ...15 more annotations...
  • I think this is quite a new concept because not until recently have we begun to understand a little bit more about the aging process and find some biochemical pathways that are at the root of aging processes.
  • Now what do you see as the greatest challenges for developing drugs that deal with aging? Would you say that it’s more regulatory and policy wise, or is this more scientific?
  • I think there is both.
  • When I was heading aging at Glaxo Smith Kline, the issues that I faced were that I was very interested in developing medications for frailty and weakness in muscle for when people get old because when people get weak they usually stop eating and then they fall and break a hip and end up in the hospital and die potentially, but the regulatory apparatus isn’t there yet.
  • Sarcopenia isn’t recognized as an official disease by the FDA, so the pathway to get drugs approved for frailty and to get more people mobile and into society is just not there, and so it’s a really difficult problem, and the pathways for osteoporosis are still very cumbersome, requiring fracture analysis.
  • There isn’t an approved, for example, like Jack Coralnick uses a scale at NIH to test people’s function. I think there is a critical need to have the FDA to recognize some battery of functional tests
  • how a reform would take place
  • Well we have a new FDA now, hopefully, but it’s going to take companies and scientists going to the FDA and to Congress to say “look the patient population is aging and currently we have a bottleneck, we can’t get these medicines through” and try to work out some new policy. Hopefully, the FDA will be a little more progressive about looking at endpoints. They are very, very conservative about what endpoints they will accept
  • You know, there is understandably some concern that people might use these drugs and abuse them for muscle building, but on the other hand, there is a critical unmet need out there in the elderly population
  • Well one thing is that it is quite difficult and expensive to develop drugs for aging per se because even to do pre-clinical models in animals is very expensive. It’s very expensive to get aged animals, and they don’t necessarily act like aged humans. So even in the pre-clinical stage, it’s a difficult area to work in.
  • find pathways to get these drugs approved
  • a lot of these companies are concerned as being seen as trying to produce “fountain of youth” drugs. I made it very clear when I was leading aging at GSK that I was not attempting simply to extend lifespan
  • I think this is a policy challenge and a perceptual challenge and if you will, a public relations challenge.
  • Potentially, I think we need to find more intelligent, creative ways to do clinical trials using biomarkers or other types of measures where we can get the trials through quickly
  • again, it goes back to the FDA policy. The FDA is going to have to be willing to accept some of these things, or we will not be able to get these drugs on the market
  •  
    Фармацевтика и старения (лекарства от старости)
« First ‹ Previous 81 - 100 of 212 Next › Last »
Showing 20 items per page