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Peripheral artery disease (PAD) is a major health challenge affecting millions of people worldwide. Among the arsenal of tools in the fight against PAD, percutaneous transluminal angioplasty (PTA) catheters stand out for their remarkable efficacy. In this review, we explore the pivotal role that PTA catheters play in interventions both above and below the belt, with a particular focus on their use in the pta iliaca and femoropopliteal arteries.