Obesity and Weight Loss Surgery are very hot topics nowadays. Check your obesity through online BMI calculators or consult your doctor. Obesity is a medical term. It means too much body fat. If your BMI (body mass index) is 25 to 29.9, you're overweight but of it is 30 or more then you are obese
Read how to measure weight and take healthy steps for reducing fats. Obesity is excess of your calories stored in adipose tissues as fats. BMI is used for calculating body mass in relation to stronger muscles.
Effect of increased water intake on plasma copeptin in healthy adults
PURPOSE:
Inter-individual variation in median plasma copeptin is associated with incident type 2 diabetes mellitus, progression of chronic kidney disease, and cardiovascular events. In this study, we examined whether 24-h urine osmolality was associated with plasma copeptin and whether increasing daily water intake could impact circulating plasma copeptin.
METHODS:
This trial was a prospective study conducted at a single investigating center. Eighty-two healthy adults (age 23.6 ± 2.9 years, BMI 22.2 ± 1.5 kg/m2, 50% female) were stratified based upon habitual daily fluid intake volumes: arm A (50-80% of EFSA dietary reference values), arm B (81-120%), and arm C (121-200%). Following a baseline visit, arms A and B increased their drinking water intake to match arm C for a period of 6 consecutive weeks.
RESULTS:
At baseline, plasma copeptin was positively and significantly associated with 24-h urine osmolality (p = 0.002) and 24-h urine specific gravity (p = 0.003) but not with plasma osmolality (p = 0.18), 24-h urine creatinine (p = 0.09), and total fluid intake (p = 0.52). Over the 6-week follow-up, copeptin decreased significantly from 5.18 (3.3;7.4) to 3.90 (2.7;5.7) pmol/L (p = 0.012), while urine osmolality and urine specific gravity decreased from 591 ± 206 to 364 ± 117 mOsm/kg (p < 0.001) and from 1.016 ± 0.005 to 1.010 ± 0.004 (p < 0.001), respectively.
CONCLUSIONS:
At baseline, circulating levels of copeptin were positively associated with 24-h urine concentration in healthy young subjects with various fluid intakes. Moreover, this study shows, for the first time, that increased water intake over 6 weeks results in an attenuation of circulating copeptin.
CLINICAL TRIAL REGISTRATION NUMBER:
NCT02044679.
KEYWORDS:
Copeptin; Fluid intake; Hydration; Urine osmolality; Water intake; drinking water
Effect of increased water intake on plasma copeptin in healthy adults