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Conjugated linoleic acid (CLA) supplementation is associated with an increase in serum C-reactive protein (CRP) concentration, according to a review and meta-analysis published online May 29 in Cardiovascular Therapeutics. Mohsen Mazidi, Ph.D., from the Chinese Academy of Sciences in Beijing, and colleagues conducted a systematic review and meta-analysis to examine the impact of CLA supplementation on serum CRP. Data were included from 14 studies. The researchers found that following supplementation with CLAs there was a significant increase in serum CRP concentrations (weighted mean difference, 0.63 mg/dL; 95 percent confidence interval, 0.13 to 1.13; heterogeneity P = 0.026); these findings were robust in sensitivity analyses. The changes in serum CRP levels were found to be independent of CLA supplementation dosage (slope, −0.02; 95 percent confidence interval, −0.10 to 0.12; P = 0.889) or follow-up duration (slope, 0.271; 95 percent confidence interval, −0.05 to 0.59; P = 0.098). "This meta-analysis suggests that CLA supplementation is associated with an increase in plasma CRP concentrations and a reduction in serum adiponectin concentrations, which indicates that CLA supplements have a pro-inflammatory effect," the authors write.

For patients with stage 4 or 5 chronic kidney disease and hepatitis C virus (HCV) infection, 12 weeks of treatment with glecaprevir and pibrentasvir results in a high rate of sustained virologic response, according to a study published online Oct. 11 in the New England Journal of Medicine. Edward Gane, M.D., from Auckland City Hospital in New Zealand, and colleagues conducted a multicenter trial to examine the efficacy and safety of combination treatment with the NS3/4A protease inhibitor glecaprevir and the NS5A inhibitor pibrentasvir for 12 weeks in adults with HCV infection and compensated liver disease with severe renal impairment, dependence on dialysis, or both. Participants had stage 4 or 5 chronic kidney disease. One hundred four patients were enrolled in the trial. The researchers found that the sustained virologic response rate was 98 percent. During treatment, none of the patients had virologic failure, and none had a virologic relapse after the end of treatment. Pruritus, fatigue, and nausea were reported in at least 10 percent of the patients. Twenty-four percent of the patients reported serious adverse events. Because of adverse events, four patients discontinued the trial treatment prematurely; three of these had sustained virologic response

MedCab: Best 24/7 Ambulance Service in Chinhat, Lucknow For the best ambulance service in Chinhat, MedCab is the most-called emergency ambulance number. MedCab offers 24/7 availability of ambulance services in Chinhat. This makes MedCab the best ambulance service in the area. The Indian Rebels were led by Barkat Ahmad and were able to win the Battle of Chinhat. Chinhat is located on the outskirts of Lucknow. It is a village area. Much like the rest of Lucknow, Chinhat also has a rich history related to Indian independence. It is famously known for the Battle of Chinhat which was fought between the British forces and Indian freedom fighters. The Battle of Chinhat led to the marking of the Siege of Lucknow, an extremely important event in the history of Indian independence. While being an important place of Indian history, Chinhat is majorly a residential area in the present. Chinhat has a lot of famous temples, such as the Arya Samaj Mandir and Shakti Dham Mandir. It also has some good schools, such as the Siddhant World School. Chinhat is in close proximity to Gomti Nagar.

Dual-graft (DG) adult living donor liver transplantation (ALDLT) with ABO-incompatible (ABOi) and ABO-compatible (ABOc) graft combination is associated with high rates of graft survival, with no significant difference for ABOi and ABOc grafts, according to research published online July 31 in the American Journal of Transplantation. Jae Hyun Kwon, M.D., from the University of Ulsan College of Medicine in Seoul, South Korea, and colleagues conducted a retrospective review of medical records of patients who underwent ABOi DG ALDLT between 2008 and 2014. The authors also assessed the graft regeneration rate using computed tomography volumetric analysis. During a mean follow-up of 57.0 ± 22.4 months, the researchers found that the one-, three-, and five-year patient survival rate was 96.4 percent. The rate of graft survival at one-, three-, and five-years was 96.4, 94.2, and 92.0 percent, respectively; ABOc and ABOi grafts did not differ significantly (P = 0.145). No significant differences were seen between ABOc and ABOi grafts in the biliary complication rate (P = 0.195). There was no significant difference in regeneration rates for ABOi and ABOc grafts. "DG ALDLT with ABOi and ABOc graft combination seems to be a feasible option for expanding the donor pool without additional donor risks," the authors write.

Too many carbs, not fats, may be the culprit in raising risk of premature death, according to a study published online Aug. 29 in the The Lancet to coincide with the European Society of Cardiology Congress 2017, held from Aug. 26 to 30 in Barcelona, Spain. Mahshid Dehghan, Ph.D., an investigator with the Population Health Research Institute at McMaster University in Hamilton, Canada, and colleagues tracked the diet and health of 135,335 people, aged 35 to 70, from 18 countries around the world, to gain a global perspective on the health effects of diet. Participants provided detailed information on their social and economic status, lifestyle, medical history, and current health. They also completed a questionnaire on their regular diet, which researchers used to calculate their average daily calories from fats, carbohydrates, and proteins. The research team then tracked the participants' health for about seven years on average, with follow-up visits at least every three years. The investigators found that high-carbohydrate diets are common, with more than half of the people deriving 70 percent of their daily calories from carbs. People with a high fat intake -- about 35 percent of their daily diet -- had a 23 percent lower risk of early death and 18 percent lower risk of stroke compared to people who ate less fat. The researchers also noted that a very low intake of saturated fats (below 3 percent of daily diet) was associated with a higher risk of death in the study, compared to diets containing up to 13 percent daily. At the same time, high-carb diets -- containing an average 77 percent carbohydrates -- were associated with a 28 percent increased risk of death versus low-carb diets. "The study showed that contrary to popular belief, increased consumption of dietary fats is associated with a lower risk of death," Dehghan told HealthDay. "We found no evidence that below 10 percent of energy by saturated fat is beneficial, and going below 7 percent may even be har

Looking for an Urgent Ambulance Service in Aishbagh? Call MedCab for Quick Help! Do you need quick and urgent medical assistance in Aishbagh, Lucknow? Then, search no further and contact MedCab through their 24/7 emergency number 18008-908-208. MedCab offers the fastest ambulance services in Aishbagh. Aishbagh is an industrial and residential area in Lucknow. Lucknow is famous for being the 'city of gardens' and Aishbagh contains one of these historical gardens. The Garden pavilions in the location were developed by Asaf-Ud-Dowlah. Besides this, Aishbagh is also the centre for the important railway station known as the Aishbagh railway station. It is an important railway station for the Lucknow railway line. As an industrial area, Aishbagh also has a number of plywood factories. Aishbagh is also known for the Mosque Eidgah. Besides this, Aishbagh also has the Ramleela Ground and Samadhi Temple. Aishbagh is also close to important locations in Lucknow, such as the Bara Imambara and the Nawab Wajid Ali Shah Zoological Park. Medical emergencies can arise unexpectedly even in Aishbagh. For urgent medical assistance in Aishbagh, MedCab is the best ambulance provider available.

MedCab: A 24/7 Quick Ambulance Service in Gomti Nagar, Lucknow Are you looking for an urgent ambulance service in Gomti Nagar, Lucknow? For fast and reliable transportation, call MedCab. MedCab offers urgent medical assistance and reliable booking. MedCab is known for being one of the most reliable ambulance services in Gomti Nagar. MedCab has a 24/7 reliable booking facility and caters to ICU services, ventilator, and oxygen support needs of patients. We offer the best ambulance service in Gomti Nagar. Ambulance services are offered for Gomti Nagar Phase-I, Gomti Nagar Phase-II, and Gomti Nagar Extension. Gomti Nagar is the most populous area of Lucknow. It is one of the fastest-growing areas in Lucknow. It is a commercial hub as well as a residential area. It has various popular malls. These include Wave Mall, City Mall, Fun Republic Mall, One Awadh Center, and Singapore Mall. Being home to multiple high-end projects, clubs and multiplexes, Gomti Nagar is famous for being one of the largest Asian colonies. Most houses in Gomti Nagar are based on the open space concept and are usually in the form of beautiful plots with an open space facing parks. Another important historical building in Gomti Nagar is the Dr. Bhimrao Ambedkar Samajik Parivartan Sthal. This public memorial is dedicated to Dr. Bhimrao Ambedkar. The famous Ekana Cricket Stadium is also located at the Gomti Nagar Extension. Some of the matches of the 2023 ICC Men's Cricket World Cup were hosted here. Gomti Nagar also has its own railway station known as the Gomti Nagar Railway Station. How would you handle a medical emergency in any of these areas? Contact MedCab through their emergency ambulance number which runs 24/7.