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For patients with stage 4 or 5 chronic kidney disease and hepatitis C virus (HCV) infection, 12 weeks of treatment with glecaprevir and pibrentasvir results in a high rate of sustained virologic response, according to a study published online Oct. 11 in the New England Journal of Medicine. Edward Gane, M.D., from Auckland City Hospital in New Zealand, and colleagues conducted a multicenter trial to examine the efficacy and safety of combination treatment with the NS3/4A protease inhibitor glecaprevir and the NS5A inhibitor pibrentasvir for 12 weeks in adults with HCV infection and compensated liver disease with severe renal impairment, dependence on dialysis, or both. Participants had stage 4 or 5 chronic kidney disease. One hundred four patients were enrolled in the trial. The researchers found that the sustained virologic response rate was 98 percent. During treatment, none of the patients had virologic failure, and none had a virologic relapse after the end of treatment. Pruritus, fatigue, and nausea were reported in at least 10 percent of the patients. Twenty-four percent of the patients reported serious adverse events. Because of adverse events, four patients discontinued the trial treatment prematurely; three of these had sustained virologic response

Hypertension: When to Call an Ambulance for High BP? Hypertension: When to Call an Ambulance for High BP? Hypertension, also known as high blood pressure, is a common condition in India. It can be very serious if it is not treated. As per a WHO (2023) report, 46% of adults are unaware that they have hypertension [1]. It is a type of 'silent killer' as individuals are usually not aware that something is wrong with their body due to the absence of major symptoms. The major high BP symptom is the blood pressure being over 180/120 mm Hg. This means there is a hypertensive crisis and you should call an ambulance in such a case. Read on to understand hypertension signs, reasons for high BP, and how to handle an emergency during a hypertensive crisis. Call MedCab emergency ambulance services for a hypertensive crisis or other medical emergencies by dialling the emergency ambulance number at 18008-908-208. What is Hypertension? Hypertension or high BP refers to the force of blood pushing against the artery walls being very high on a consistent basis. The heart would have to work harder to pump blood in the body during high BP. Untreated hypertension can have serious repercussions, such as stroke, heart attack, kidney failure and eye damage. To understand hypertension better, categorisations of BP are listed below - Normal BP - For BP to be considered normal, it should be under 120/80 mm Hg. Elevated BP - One would be considered to have elevated BP if the top number is between 120 to 129 mm Hg, while the bottom number is under 80 mm Hg. Stage 1 Hypertension - For stage 1 hypertension, the top number of the reading would be between 130 to 139 mm Hg, while the bottom number would show between 80 and 89 mm Hg. Stage 2 Hypertension - This is the most dangerous state of hypertension, and the top number is 140 mm Hg or more, and the lower number is 90 mm Hg or more. While usually high BP does not have noticeable signs and needs to be measured using t