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In the preceding article, we discussed the application of hot-melt extrusion technology in developing amorphous solid dispersions (ASD) for pharmaceutical formulations. The process involves dispersing a solution through a spray dryer, where it meets hot gas, quickly evaporates, and forms amorphous solids. Spray drying techniques are extensively employed in developing formulations for drugs with low solubility, largely due to their well-established scalability from small-scale experiments to large-scale commercial production, aligning with Good Manufacturing Practice (GMP) standards. Table 1 in the article provides examples of various drugs that have been commercially produced using spray drying technology to prepare amorphous solid dispersions.

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