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More evidence today that our genes aren't always our destiny -- with an inconvenient caveat for couch potatoes: Physically active people who carry gene mutations linked to obesity are no more likely to be overweight than those without the variants -- as long as they exercise at least three hours a day.

But the gene's "obese-ogenic" effect may be turned on by high-fat diets, inactivity or other environmental factors, Snitker said.