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2-APB is a nonspecific antagonist of calcium channels, commonly used in studies of calcium signaling, such as in apoptosis, muscle contraction, and neural transmission. It is a membrane-permeable inhibitor of the inositol-1,4,5-trisphosphate (InsP3) sensitive Ca2+ channels, with an IC50 value of 42μM when the concentration of InsP3 is 100nm[1]. Additionally, 2-APB has been found to affect the activity of TRP channels at certain concentrations [2].

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