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Matti Narkia

VitaminD3 - Ted Hutchinson's blog - 0 views

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    "Thursday, 17 December 2009
    This blog is in response to Dr Briffa's post here. as I keep having problems commenting on his blogs.

    While 44ng/ml is sufficient to not only maximize uptake of calcium (>32ng/ml) and ensure maximum bone mineral density (>42ng/ml), pregnant and nursing mothers should be aware that in order to maximize the amount of vitamin D3 in human breast milk 6400iu/daily was found to be necessary to raise (>58ng/ml) at latitude 32.
    This is detailed in the Taylor, Wagner and Hollis paper.
    Vitamin D supplementation during lactation to support infant and mother.
    Although 4000iu/daily met the mothers daily needs in full it left babies being born with lower 25(OH)D status than required for optimum calcium absorption

    They also found DAILY use of supplements was required by pregnant and nursing mothers to ensure an even daily Vitamin D3 supply to the foetus & baby.
    It makes virtually no measurable difference for everyone else if you supplement daily or weekly.

    While Dr Briffa will not be lactating he may be interested seeing in the
    Grassrootshealth chart showing disease incidence by 25(OH)D status.
    this may encourage him to go just another 10ng/ml higher and a bit nearer to the natural level at which human breast milk flows replete with D3."
Matti Narkia

Bread Fortified with Cholecalciferol Increases the Serum 25-Hydroxyvitamin D Concentrat... - 0 views

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    Bread fortified with cholecalciferol increases the serum 25-hydroxyvitamin D concentration in women as effectively as a cholecalciferol supplement.
    Natri AM, Salo P, Vikstedt T, Palssa A, Huttunen M, Kärkkäinen MU, Salovaara H, Piironen V, Jakobsen J, Lamberg-Allardt CJ.
    J Nutr. 2006 Jan;136(1):123-7.
    PMID: 16365070

    Both fortified breads increased serum 25-hydroxyvitamin D concentration as effectively as the cholecalciferol supplement. Supplementation or fortification did not affect serum intact parathyroid hormone concentration or urinary calcium excretion. In conclusion, fortified bread is a safe and feasible way to improve vitamin D nutrition.
Matti Narkia

A randomised comparison of increase in serum 25-hydroxyvitamin D concentratio... - 0 views

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    A randomised comparison of increase in serum 25-hydroxyvitamin D concentration after 4 weeks of daily oral intake of 10 microg cholecalciferol from multivitamin tablets or fish oil capsules in healthy young adults.
    Holvik K, Madar AA, Meyer HE, Lofthus CM, Stene LC.
    Br J Nutr. 2007 Sep;98(3):620-5. Epub 2007 Apr 24.
    PMID: 17456248

    We conclude that fish oil capsules and multivitamin tablets containing 10 microg cholecalciferol administered over a 4-week period produced a similar mean increase in s-25(OH)D concentration.
Matti Narkia

Estimation and Fortification of Vitamin D3 in Pasteurized Process Cheese -- Upreti et a... - 0 views

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    Estimation and fortification of vitamin D3 in pasteurized process cheese.
    Upreti P, Mistry VV, Warthesen JJ.
    J Dairy Sci. 2002 Dec;85(12):3173-81.
    PMID: 12512590


    The objective of this study was to develop methods for the estimation and fortification of vitamin D3 in pasteurized Process cheese. Vitamin D3 was estimated using alkaline saponification at 70°C for 30 min, followed by extraction with petroleum ether:diethyl ether (90:10 vol/vol) and HPLC. The retention time for vitamin D3 was approximately 9 min. A standard curve with a correlation coefficient of 0.972 was prepared for quantification of vitamin D3 in unknown samples. In the second phase of the study, pasteurized Process cheeses fortified with commercial water- or fat-dispersible forms of vitamin D3 at a level of 100 IU per serving (28 g) were manufactured. There was no loss of vitamin D3 during Process cheese manufacture, and the vitamin was uniformly distributed. No losses of the vitamin occurred during storage of the fortified cheeses over a 9-mo period at 21 to 29°C and 4 to 6°C. There was an approximately 25 to 30% loss of the vitamin when cheeses were heated for 5 min in an oven maintained at 232°C. Added vitamin D3 did not impart any off flavors to the Process cheeses as determined by sensory analysis. There were no differences between the water- and fat-dispersible forms of the vitamin in the parameters measured in fortified cheeses
Matti Narkia

The role of Vitamin D3 metabolism in prostate cancer - ScienceDirect - The Journal of S... - 1 views

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    The role of Vitamin D3 metabolism in prostate cancer.
    Lou YR, Qiao S, Talonpoika R, Syvälä H, Tuohimaa P.
    J Steroid Biochem Mol Biol. 2004 Nov;92(4):317-25. Epub 2004 Dec 19. Review.
    PMID: 15663995
    doi:10.1016/j.jsbmb.2004.10.007

    In summary, the local metabolism of hormonal Vitamin D seems to play an important role in the development and progression of prostate cancer.
Matti Narkia

The solar UV radiation level needed for cutaneous production of vitamin D3 in the face.... - 0 views

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    The solar UV radiation level needed for cutaneous production of vitamin D3 in the face. A study conducted among subjects living at a high latitude (68 degrees N).
    Edvardsen K, Brustad M, Engelsen O, Aksnes L.
    Photochem Photobiol Sci. 2007 Jan;6(1):57-62. Epub 2006 Nov 10.
    PMID: 17200737
Matti Narkia

Vitamin D effective ultraviolet wavelengths due to scattering in shade - ScienceDirect ... - 0 views

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    Vitamin D effective ultraviolet wavelengths due to scattering in shade.
    Turnbull DJ, Parisi AV, Kimlin MG.
    J Steroid Biochem Mol Biol. 2005 Sep;96(5):431-6. Epub 2005 Jul 6.
    PMID: 16005208
Matti Narkia

Vitamin D3 and 25-hydroxyvitamin D3 in raw and cooked pork cuts - ScienceDirect - Journ... - 0 views

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    Vitamin D3 and 25-hydroxyvitamin D3 in raw and cooked pork cuts.
    Ina Clausen, Jette Jakobsen, Torben Leth and Lars Ovesen.
    Journal of Food Composition and Analysis
    Volume 16, Issue 5, October 2003, Pages 575-585
    doi:10.1016/S0889-1575(03)00064-4

    Meat 25OHD3 contributes significantly to vitamin D activity. Food databases should include concentrations of both vitamin D and 25OHD.
Matti Narkia

Concentrations of vitamin D3 and 25-hydroxyvitamin D3 in raw and cooked New Zealand bee... - 0 views

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    Concentrations of vitamin D3 and 25-hydroxyvitamin D3 in raw and cooked New Zealand beef and lamb.
    Roger Purchas, Maggie Zoua, Philip Pearcea and Felicity Jackson-
    Journal of Food Composition and Analysis
    Volume 20, Issue 2, March 2007, Pages 90-98

    For lamb, the highest levels of vitamin D3 were in the shoulder chop both before and after cooking, while levels were lowest in the rack muscle. Similar cut differences were shown for 25OHD3 concentrations. For beef there were no significant differences between the cuts for vitamin D3, but concentrations of 25OHD3 were lower in the striploin before and after cooking, Vitamin D3 levels tended to be higher in beef cuts than in lamb cuts, but the opposite held for 25OHD3. Concentrations of vitamin D3 were similar to those in other reports, but the 25OHD3 levels were at the high end of reported ranges. With 25OHD3 being more potent than vitamin D3, it is concluded that meat can make a useful contribution of this vitamin to the human diet.
Matti Narkia

Cholecalciferol - Wikipedia, the free encyclopedia - 0 views

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    "Cholecalciferol is a form of Vitamin D, also called vitamin D3 or calciol.[1]

    It is structurally similar to steroids such as testosterone, cholesterol, and cortisol (though vitamin D3 itself is a secosteroid).

    One gram of pure vitamin D3 is 40 000 000 (40x106) IU, or, in other words, one IU is 0.025 μg. Individuals having a high risk of deficiency should consume 125 μg (5000 IU) of vitamin D daily"
Matti Narkia

The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Ch... - 0 views

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    The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets.
    Thacher TD, Obadofin MO, O'Brien KO, Abrams SA.
    J Clin Endocrinol Metab. 2009 Sep;94(9):3314-21. Epub 2009 Jun 30.
    PMID: 19567516

    Conclusions: Despite similar increases in 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with vitamin D2 or vitamin D3, fractional calcium absorption did not increase, indicating that rickets in Nigerian children is not primarily due to vitamin D-deficient calcium malabsorption
Matti Narkia

Correlation of symptoms with vitamin D deficiency and symptom response to cholecalcifer... - 0 views

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    Correlation of symptoms with vitamin D deficiency and symptom response to cholecalciferol treatment: a randomized controlled trial.
    Arvold DS, Odean MJ, Dornfeld MP, Regal RR, Arvold JG, Karwoski GC, Mast DJ, Sanford PB, Sjoberg RJ.
    Endocr Pract. 2009 May-Jun;15(3):203-12.
    PMID: 19364687

    Conclusions: Compared with participants in the placebo group, patients in the treatment group showed mild short-term improvement in the overall fibromyalgia impact score, but did not show significant improvement in most musculoskeletal symptoms or in activities of daily living.
Matti Narkia

Animal Pharm: 'Roid Rage: Vitamin D3 - DO IT (Part I) - 0 views

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    "Naturally, we are all mildly worried about the swine flu (the delayed 'flu' season). Taking Vitamin D will certainly provide several layers of protection for our family and hopefully avert potential complications. Studies show 36% of individuals who are Vitamin D deficient develop respiratory infections"
Matti Narkia

High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their inf... - 0 views

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    High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study.
    Wagner CL, Hulsey TC, Fanning D, Ebeling M, Hollis BW.
    Breastfeed Med. 2006 Summer;1(2):59-70.
    PMID: 17661565
    doi:10.1089/bfm.2006.1.59.

    Objective: To examine the effect of high-dose maternal vitamin D3 (vitD) supplementation on the nutritional vitD status of breastfeeding (BF) women and their infants compared with maternal and infant controls receiving 400 and 300 IU vitD/day, respectively.

    Design: Fully lactating women (n = 19) were enrolled at 1-month postpartum into a randomized- control pilot trial. Each mother received one of two treatments for a 6-month study period: 0 or 6000 IU vitD3 plus a prenatal vitamin containing 400 IU vitD3. The infants of mothers assigned to the control group received 300 IU vitD3/day; those infants of mothers in the high-dose group received 0 IU (placebo). Maternal serum and milk vitD and 25(OH)D were measured at baseline then monthly; infant serum vitD and 25(OH)D were measured at baseline, and months 4 and 7. Urinary calcium/creatinine ratios were measured monthly in both mothers and infants. Dietary and BF history and outdoor activity questionnaires were completed at each visit. Changes in skin pigmentation were measured by spectrophotometry. Data were analyzed using chi-square, t-test, and analysis of variance (ANOVA) on an intent-to-treat basis.

    Conclusion: With limited sun exposure, an intake of 400 IU/day vitamin D3 did not sustain circulating maternal 25(OH)D levels, and thus, supplied only extremely limited amounts of vitamin D to the nursing infant via breast milk. Infant levels achieved exclusively through maternal supplementation were equivalent to levels in infants who received oral vitamin D supplementation. Thus, a maternal intake of 6400 IU/day vitamin D elevated circulating 25(OH)D in both mother and nursing infant.
Matti Narkia

VITAMIN D LOWERS C-REACTIVE PROTEIN (CRP) - 0 views

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    VITAMIN D LOWERS C-REACTIVE PROTEIN (CRP)
    Van den Berghe and colleagues at the University of Leuven in Belgium appear to be the first to show that simple, natural and cheap vitamin D (cholecalciferol) lowers CRP in critically ill patients. Even small amounts of cholecalciferol (500 IU) lowered CRP by more than 25% in a small group of critically ill patients. Another marker of inflammation (IL-6) was reduced even more. The researchers also found that critically ill patients were profoundly deficient in vitamin D.
Matti Narkia

Plasma Vitamin D and 25OHD Responses of Young and Old Men to Supplementation with Vitam... - 0 views

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    Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3.
    Harris SS, Dawson-Hughes B.
    J Am Coll Nutr. 2002 Aug;21(4):357-62.
    PMID: 12166534

    Conclusions: There appears to be no age-related impairment among men in the absorption or metabolism of 20 µg/day of vitamin D3 taken orally for at least eight weeks.
Matti Narkia

Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after ... - 0 views

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    Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol.
    Glendenning P, Chew GT, Seymour HM, Gillett MJ, Goldswain PR, Inderjeeth CA, Vasikaran SD, Taranto M, Musk AA, Fraser WD.
    Bone. 2009 Nov;45(5):870-5. Epub 2009 Jul 23.
    PMID: 19631774
    doi:10.1016/j.bone.2009.07.015

    Cholecalciferol supplementation resulted in a 31% greater increase in total HPLC-measured 25OHD (p=0.010) and 52% greater rise in RIA-measured 25OHD (p<0.001) of supplementation dose with than ergocalciferol equivalent an>0.05). In vitamin D-insufficient hip fracture patients, supplementation with cholecalciferol 1000 IU/day for three months was more effective in increasing serum 25OHD than an equivalent dose of ergocalciferol. However, the lack of difference in PTH lowering between calciferol treatments raises questions about the biological importance of this observation.
Matti Narkia

Vitamin D and multiple sclerosis. [Proc Soc Exp Biol Med. 1997] - PubMed Result - 0 views

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    Vitamin D and multiple sclerosis.
    Hayes CE, Cantorna MT, DeLuca HF.
    Proc Soc Exp Biol Med. 1997 Oct;216(1):21-7. Review.
    PMID: 9316607
Matti Narkia

NEJM -- Vitamin D3 and calcium to prevent hip fractures in the elderly women - 0 views

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    Vitamin D3 and calcium to prevent hip fractures in the elderly women.
    Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ.
    N Engl J Med. 1992 Dec 3;327(23):1637-42.
    PMID: 1331788

    CONCLUSIONS. Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.
Matti Narkia

The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implicati... - 0 views

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    The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers.
    Vasquez A, Manso G, Cannell J.
    Altern Ther Health Med. 2004 Sep-Oct;10(5):28-36; quiz 37, 94. Review.
    PMID: 15478784
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