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Matti Narkia

Seasonality of UV-radiation and vitamin D status at 69 degrees north. - Photochem Photo... - 1 views

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    Seasonality of UV-radiation and vitamin D status at 69 degrees north.
    Brustad M, Edvardsen K, Wilsgaard T, Engelsen O, Aksnes L, Lund E.
    Photochem Photobiol Sci. 2007 Aug;6(8):903-8. Epub 2007 Jun 27.
    PMID: 17668121

    The generally high dietary intakes of vitamin D, especially in winter, mask largely the effect of seasonal variation in UV-exposure, causing an atypical seasonal variation in vitamin D status. The UV-hour variable significantly predicted 25(OH)D levels in blood when adjusted for intakes and artificial UV-radiation exposure and sun holidays abroad.
Matti Narkia

The High Prevalence of Vitamin D Insufficiency across Australian Populations Is Only Pa... - 1 views

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    The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude.
    van der Mei IA, Ponsonby AL, Engelsen O, Pasco JA, McGrath JJ, Eyles DW, Blizzard L, Dwyer T, Lucas R, Jones G.
    Environ Health Perspect. 2007 Aug;115(8):1132-9.
    PMID: 17687438
    doi: 10.1289/ehp.9937.

    Conclusion
    Vitamin D insufficiency is common over a wide latitude range in Australia. Season appears to be more important than latitude, but both accounted for less than one-fifth of the variation in serum 25(OH)D levels, highlighting the importance of behavioral factors. Current sun exposure guidelines do not seem to fully prevent vitamin D insufficiency, and consideration should be given to their modification or to pursuing other means to achieve vitamin D adequacy.
Matti Narkia

The solar UV radiation level needed for cutaneous production of vitamin D3 in the face.... - 0 views

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    The solar UV radiation level needed for cutaneous production of vitamin D3 in the face. A study conducted among subjects living at a high latitude (68 degrees N).
    Edvardsen K, Brustad M, Engelsen O, Aksnes L.
    Photochem Photobiol Sci. 2007 Jan;6(1):57-62. Epub 2006 Nov 10.
    PMID: 17200737
Matti Narkia

Vitamin D association with estradiol and progesterone in young women - Cancer Causes Co... - 0 views

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    Vitamin D association with estradiol and progesterone in young women.
    Knight JA, Wong J, Blackmore KM, Raboud JM, Vieth R.
    Cancer Causes Control. 2009 Nov 15. [Epub ahead of print]
    PMID: 19916051

    Conclusions Higher levels of vitamin D may reduce progesterone and estradiol, providing a potential mechanism for reduction in breast cancer risk from increased vitamin D exposure in young women
Matti Narkia

Low vitamin D levels associated with several risk factors in teenagers - 0 views

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    "* Low levels of vitamin D were associated with increased risk of high blood pressure, high blood sugar and metabolic syndrome in teenagers.
    * The highest levels of vitamin D were found in whites, the lowest levels in blacks and intermediate levels in Mexican-Americans.

    PALM HARBOR, Fla., March 11, 2009 - Low levels of vitamin D were associated with an increased risk of high blood pressure, high blood sugar and metabolic syndrome in teenagers, researchers reported at the American Heart Association's 49th Annual Conference on Cardiovascular Disease Epidemiology and Prevention."
Matti Narkia

High doses of vitamin D could cut relapse rate among MS sufferers - Times Online - 0 views

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    "Powerful new evidence about the ability of vitamin D to stem a wide range of diseases has brought the prospect of a nationwide programme to prescribe it in Scotland as a dietary supplement significantly closer.

    Reports at the weekend suggested that experts were increasingly convinced that the so-called sunshine drug - whose significance was first revealed in detail by The Times last year - could make a difference to the country's appalling health record.

    New research suggests that high doses of vitamin D could dramatically cut the relapse rate in people with multiple sclerosis. According to scientists in Canada, more than a third of sufferers taking high levels of supplement
Matti Narkia

Safety of vitamin D3 in adults with multiple sclerosis -- Kimball et al. 86 (3): 645 --... - 0 views

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    Safety of vitamin D3 in adults with multiple sclerosis.
    Kimball SM, Ursell MR, O'Connor P, Vieth R.
    Am J Clin Nutr. 2007 Sep;86(3):645-51.
    PMID: 17823429

    Conclusions: Patients' serum 25(OH)D concentrations reached twice the top of the physiologic range without eliciting hypercalcemia or hypercalciuria. The data support the feasibility of pharmacologic doses of vitamin D3 for clinical research, and they provide objective evidence that vitamin D intake beyond the current upper limit is safe by a large margin.
Matti Narkia

Vitamin D and MS: Burton - 0 views

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    "Dr. Jodie Burton is the acting principal investigator (PI) of the dose-escalation trial of oral vitamin D3 with calcium supplementation in patients with multiple sclerosis with Dr. O'Connor. She started the trial as his fellow, while doing an additional 2 years of training in MS specifically after she received her neurology certification. She completed her fellowship training in 2007. Now she is staff doing clinical research and continuing with the vitamin D trial. As of August 2009, she will be Assistant Professor in Neurology in the Department of Clinical Neuroscience in Calgary and at the University of Calgary. She will be part of the MS team there with Dr. Luanne Metz and the MS group.

    Please scroll down for an abstract of the trial:
    A Phase I/II dose-escalation trial of oral vitamin D3 with calcium supplementation in patients with multiple sclerosis."

    Conclusions:
    High-dose VD3 (~10 000 IU/day, possibly higher) in MS is safe and tolerable, with evidence of clinical improvement."
Matti Narkia

High Doses of Vitamin D Cut MS Relapses - 0 views

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    "April 28, 2009 (Seattle) -- High doses of vitamin D dramatically cut the relapse rate in people with multiple sclerosis, a study shows.

    Sixteen percent of 25 people with multiple sclerosis (MS) given an average of 14,000 international units (IU) of vitamin D a day for a year suffered relapses, says Jodie Burton, MD, a neurologist at the University of Toronto. In contrast, close to 40% of 24 MS patients who took an average of 1,000 IU a day -- the amount recommended by many MS specialists -- relapsed, she says.

    Also, people taking high-dose vitamin D suffered 41% fewer relapses than the year before the study began, compared with 17% of those taking typical doses.

    People taking high doses of vitamin D did not suffer any significant side effects, Burton tells WebMD."
Matti Narkia

Low vitamin D raises blood pressure in women: study | Health | Reuters - 0 views

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    WASHINGTON (Reuters) - Younger white women with vitamin D deficiencies are about three times more likely to have high blood pressure in middle age than those with normal vitamin levels, according to a study released on Thursday.

    The study, presented at a meeting of the American Heart Association in Chicago, adds younger women to a growing list of people including men who may develop high blood pressure at least in part because of low vitamin D.
Matti Narkia

Healthy elderly French women living at home have secondary hyperparathyroidism and high... - 0 views

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    Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter. EPIDOS Study Group.
    Chapuy MC, Schott AM, Garnero P, Hans D, Delmas PD, Meunier PJ.
    J Clin Endocrinol Metab. 1996 Mar;81(3):1129-33.
    PMID: 8772587

    These results show that vitamin D status of a French aged population in good health and living at home depends mainly on lifestyle. Like institutionalized women, old women living at home exhibit clear evidence of senile hyperparathyroidism in the winter, secondary in part to a reduced 25OHD level and associated with biological signs of increased bone turnover. The maintenance of PTH within the normal range for healthy adults by vitamin D and calcium treatment might constitute an approach for the prevention of bone loss in the entire
Matti Narkia

A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients. - J Inte... - 0 views

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    A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients.
    Kauppinen-Mäkelin R, Tähtelä R, Löyttyniemi E, Kärkkäinen J, Välimäki MJ.
    J Intern Med. 2001 Jun;249(6):559-63.
    PMID: 11422663
    DOI: 10.1046/j.1365-2796.2001.00847.x

    CONCLUSION: Hypovitaminosis D is very common amongst Finnish in- and outpatients in both sexes, causing secondary hyperparathyroidism in females. More extensive studies are warranted to elucidate the vitamin D status of the Finnish population.
Matti Narkia

Both high and low levels of blood vitamin D are associated with a higher prostate cance... - 0 views

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    Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries.
    Tuohimaa P, Tenkanen L, Ahonen M, Lumme S, Jellum E, Hallmans G, Stattin P, Harvei S, Hakulinen T, Luostarinen T, Dillner J, Lehtinen M, Hakama M.
    Int J Cancer. 2004 Jan 1;108(1):104-8.
    PMID: 14618623
    DOI: 10.1002/ijc.11375
Matti Narkia

Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension Among Young Women -... - 0 views

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    Plasma 25-hydroxyvitamin D levels and risk of incident hypertension among young women.
    Forman JP, Curhan GC, Taylor EN.
    Hypertension. 2008 Nov;52(5):828-32. Epub 2008 Oct 6.
    PMID: 18838623
    doi: 10.1161/HYPERTENSIONAHA.108.117630

    Women in the lowest compared with highest quartile of plasma 25(OH)D had an adjusted odds ratio for incident hypertension of 1.66 (95% CI: 1.11 to 2.48; P for trend=0.01). Compared with women with sufficient levels, those with vitamin D deficiency (<30 ng/mL; 65.7% of the study population) had a multivariable odds ratio of 1.47 (95% CI: 1.10 to 1.97). Plasma 25(OH)D levels are inversely and independently associated with the risk of developing hypertension.
Matti Narkia

High Prevalence of Vitamin D Deficiency Despite Supplementation in Premenopausal Women ... - 0 views

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    High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy.
    Crew KD, Shane E, Cremers S, McMahon DJ, Irani D, Hershman DL.
    J Clin Oncol. 2009 May 1;27(13):2151-6. Epub 2009 Apr 6.
    PMID: 19349547
    DOI: 10.1200/JCO.2008.19.6162

    Conclusion Vitamin D deficiency is highly prevalent in women with breast cancer. The current recommended dietary allowance of vitamin D is too low to increase serum 25-OHD greater than 30 ng/mL. Optimal dosing for bone health and, possibly, improved survival has yet to be determined.
Matti Narkia

The High Prevalence of Vitamin D Insufficiency cross Australian Populations Is Only Par... - 0 views

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    van der Mei IA, Ponsonby AL, Engelsen O, Pasco JA, McGrath JJ, Eyles DW, Blizzard L, Dwyer T, Lucas R, Jones G.
    The High Prevalence of Vitamin D Insufficiency across Australian Populations Is Only Partly Explained by Season and Latitude.
    Environ Health
Matti Narkia

High prevalence of vitamin D deficiency in Chilean healthy postmenopausal women with no... - 0 views

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    Gonzalez G, Alvarado JN, Rojas A, Navarrete C, Velasquez CG, Arteaga E.
    High prevalence of vitamin D deficiency in Chilean healthy postmenopausal women with normal sun exposure: additional evidence for a worldwide concern.
    Menopause. 2007 May-Jun;14(3
Matti Narkia

High prevalence of low dietary calcium, high phytate consumption, and vitamin D deficie... - 0 views

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    Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D, Srinivasarao PV, Sarma KV, Kumar EG.
    High prevalence of low dietary calcium, high phytate consumption, and vitamin D deficiency in healthy south Indians.
    Am J Clin Nutr. 2007 Apr;85(4):1062-7.
    PMID
Matti Narkia

A higher dose of vitamin d reduces the risk of falls in nursing home residents: a rando... - 0 views

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    Broe KE, Chen TC, Weinberg J, Bischoff-Ferrari HA, Holick MF, Kiel DP. \nA higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multiple-dose study.\nJ Am Geriatr Soc. 2007 Feb;55(2):234-9.\nPMID: 17302660 [PubMed -
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