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Matti Narkia

Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age... - 0 views

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    Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age.
    Cashman KD, Wallace JM, Horigan G, Hill TR, Barnes MS, Lucey AJ, Bonham MP, Taylor N, Duffy EM, Seamans K, Muldowney S, Fitzgerald AP, Flynn A, Strain JJ, Kiely M.
    Am J Clin Nutr. 2009 May;89(5):1366-74. Epub 2009 Mar 18.
    PMID: 19297462
    doi:10.3945/ajcn.2008.27334

    Conclusion: To ensure that the vitamin D requirement is met by the vast majority (>97.5%) of adults aged ≥64 y during winter, between 7.9 and 42.8 µg vitamin D/d is required, depending on summer sun exposure and the threshold of adequacy of 25(OH)D. .
Matti Narkia

Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration -- Aloia e... - 0 views

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    Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration.
    Aloia JF, Patel M, Dimaano R, Li-Ng M, Talwar SA, Mikhail M, Pollack S, Yeh JK.
    Am J Clin Nutr. 2008 Jun;87(6):1952-8.
    PMID: 18541590

    The mean daily dose was 86 microg (3440 IU). The use of computer simulations to obtain the most participants within the range of 75-220 nmol/L predicted an optimal daily dose of 115 microg/d (4600 IU). No hypercalcemia or hypercalciuria was observed. CONCLUSIONS: Determination of the intake required to attain serum 25(OH)D concentrations >75 nmol/L must consider the wide variability in the dose-response curve and basal 25(OH)D concentrations. Projection of the dose-response curves observed in this convenience sample onto the population of the third National Health and Nutrition Examination Survey suggests a dose of 95 microg/d (3800 IU) for those above a 25(OH)D threshold of 55 nmol/L and a dose of 125 microg/d (5000 IU) for those below that threshold.
Matti Narkia

How Much Vitamin D3 Do the Elderly Need? -- Viljakainen et al. 25 (5): 429 -- Journal o... - 0 views

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    How much vitamin D3 do the elderly need?
    Viljakainen HT, Palssa A, Kärkkäinen M, Jakobsen J, Lamberg-Allardt C.
    J Am Coll Nutr. 2006 Oct;25(5):429-35.
    PMID: 17031013

    Conclusions: A clear dose response was noted in S-25-OHD to different doses of vitamin D3. The recommended dietary intake of 15 µg is adequate to maintain the S-25-OHD concentration around 40-55 nmol/L during winter, but if the optimal S-25-OHD is higher than that even higher vitamin D intakes are needed. Interestingly, subjects with lower vitamin D status at baseline responded more efficiently to supplementation than those with more adequate status
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