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Matti Narkia

Vitamin D, nervous system and aging. - Tuohimaa et al. - Psychoneuroendocrinology Volum... - 0 views

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    Vitamin D, nervous system and aging.
    P. Tuohimaa, T. Keisala, A. Minasyan, J. Cachat and A. Kalueff. .
    Psychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286
    NEUROACTIVE STEROIDS: EFFECTS AND MECHANISMS OF ACTION
    doi:10.1016/j.psyneuen.2009.07.003

    This is a mini-review of vitamin D3, its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis and muscle weakness all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease, seasonal affective disorder and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.
Matti Narkia

Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk - Scien... - 1 views

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    Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk.
    Yin L, Raum E, Haug U, Arndt V, Brenner H.
    Cancer Epidemiol. 2009 Dec;33(6):435-45. Epub 2009 Nov 25.
    PMID: 19939760
    doi:10.1016/j.canep.2009.10.014

    CONCLUSIONS: According to available evidence from longitudinal studies, serum 25(OH)D is not associated with PC incidence.
Matti Narkia

Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pa... - 0 views

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    Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology.
    Peterlik M, Cross HS.
    Eur J Clin Nutr. 2009 Dec;63(12):1377-86. Epub 2009 Sep 2.
    PMID: 19724293
    doi:10.1038/ejcn.2009.105

    A compromised vitamin D status, characterized by low 25-hydroxyvitamin D (25-(OH)D) serum levels, and a nutritional calcium deficit are widely encountered in European and North American countries, independent of age or gender. Both conditions are linked to the pathogenesis of many degenerative, malignant, inflammatory and metabolic diseases. Studies on tissue-specific expression and activity of vitamin D metabolizing enzymes, 25-(OH)D-1alpha-hydroxylase and 25-(OH)D-24-hydroxylase, and of the extracellular calcium-sensing receptor (CaR) have led to the understanding of how, in non-renal tissues and cellular systems, locally produced 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and extracellular Ca2+ act jointly as key regulators of cellular proliferation, differentiation and function. Impairment of cooperative signalling from the 1,25-(OH)2D3-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency causes cellular dysfunction in many organs and biological systems, and, therefore, increases the risk of diseases, particularly of osteoporosis, colorectal and breast cancer, inflammatory bowel disease, insulin-dependent diabetes mellitus type I, metabolic syndrome, diabetes mellitus type II, hypertension and cardiovascular disease. Understanding the underlying molecular and cellular processes provides a rationale for advocating adequate intake of vitamin D and calcium in all populations, thereby preventing many chronic diseases worldwide.
Matti Narkia

Benefit-risk assessment of vitamin D supplementation. - Osteoporos Int. 2009 Dec 3. - S... - 0 views

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    Benefit-risk assessment of vitamin D supplementation.
    Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC.
    Osteoporos Int. 2009 Dec 3. [Epub ahead of print]
    PMID: 19957164

    Conclusion Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
Matti Narkia

A vitamin D nutritional cornucopia: new insights concerning the serum 25-hydroxyvitamin... - 0 views

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    A vitamin D nutritional cornucopia: new insights concerning the serum 25-hydroxyvitamin D status of the US population.
    Norman AW.
    Am J Clin Nutr. 2008 Dec;88(6):1455-6.
    PMID: 19064502
    doi:10.3945/ajcn.2008.27049

    In summary, the report of Looker et al should be required reading for all nutritionists, clinicians, and vitamin D aficionados who are decision makers with regard to 25(OH)D assays, vitamin D nutritional policy, and the care of patients with vitamin D-related diseases.
Matti Narkia

Overview of general physiologic features and functions of vitamin D -- DeLuca 80 (6): 1... - 0 views

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    Overview of general physiologic features and functions of vitamin D.
    DeLuca HF.
    Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. Review.
    PMID: 15585789
Matti Narkia

Vitamin D requirements during lactation: high-dose maternal supplementation as therapy ... - 0 views

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    Vitamin D requirements during lactation: high-dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant.
    Hollis BW, Wagner CL.
    Am J Clin Nutr. 2004 Dec;80(6 Suppl):1752S-8S.
    PMID: 15585800
Matti Narkia

Vitamin D Deficiency Syndrome (VDDS) John Jacob Cannell, MD December 27, 2003 - 0 views

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    Vitamin D is safe when used in physiological doses (those used by Nature). Physiological doses are 3,000-5,000 IU/day, from all sources (sun, diet and supplements). Should hypercalcemia occur with such doses, it is due to vitamin D hypersensitivity syndrome, not vitamin D toxicity. Vitamin D hypersensitivity syndromes include conditions such as primary hyperparathyroidism, occult cancers (especially lymphoma) or granulomatous disease (especially sarcoidosis). In such cases, treatment of vitamin D deficiency should be done under the care of a knowledgeable physician. A serum 25(OH)D, serum 1,25(OH)D, PTH and SMA will lead the clinician in the right direction.
Matti Narkia

Epidemic influenza and vitamin D. - Epidemiol Infect. 2006 Dec;134(6):1129-40. (full t... - 0 views

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    Epidemic influenza and vitamin D.
    Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E.
    Epidemiol Infect. 2006 Dec;134(6):1129-40. Epub 2006 Sep 7. Review.
    PMID: 16959053
Matti Narkia

Vitamin D toxicity, policy, and science. - JBMR Online - Journal of Bone and Mineral Re... - 0 views

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    Vitamin D toxicity, policy, and science.
    Vieth R.
    J Bone Miner Res. 2007 Dec;22 Suppl 2:V64-8. Review.
    PMID: 18290725
    doi: 10.1359/jbmr.07s221
Matti Narkia

Vitamin D and skin physiology: a D-lightful story - JBMR Online - Journal of Bone and M... - 0 views

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    Vitamin D and skin physiology: a D-lightful story.
    Holick MF, Chen TC, Lu Z, Sauter E.
    J Bone Miner Res. 2007 Dec;22 Suppl 2:V28-33.
    PMID: 18290718
    doi: 10.1359/jbmr.07s211

    Very few foods naturally contain vitamin D, and those that do have a very variable vitamin D content. Recently it was observed that wild caught salmon had between 75% and 90% more vitamin D(3) compared with farmed salmon. The associations regarding increased risk of common deadly cancers, autoimmune diseases, infectious diseases, and cardiovascular disease with living at higher latitudes and being prone to vitamin D deficiency should alert all health care professionals about the importance of vitamin D for overall health and well being.

    Humans have depended on sunlight for their vitamin D requirement. The impact of season, time of day, and latitude on vitamin D synthesis is well documented.(2,3) We now report that altitude also has a dramatic influence on vitamin D3 production and that living at altitudes above 3500 m permits previtamin D3 production at a time when very little is produced at latitudes below 3400 m. It was surprising that, at 27° N in Agra (169 M), little previtamin D3 production was observed. However, there was significant air pollution that caused a haze over the city. It is likely the ozone and other UVB-absorbing pollutants in the air prevented the solar UVB photons from reaching the earth's surface to produce previtamin D3.
Matti Narkia

Vitamin D requirements: current and future -- Weaver and Fleet 80 (6): 1735S -- America... - 0 views

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    Upper levels of vitamin D intake were set at 50 microg/d (2000 IU/d) for all ages. Some individuals would require higher levels than these to achieve serum 25-hydroxyvitamin D concentrations for optimal calcium absorption. So much new information on vitamin D and health has been collected since the requirements were set in 1997 that this nutrient is likely the most in need of revised requirements.

    Vitamin D requirements: current and future.
    Weaver CM, Fleet JC.
    Am J Clin Nutr. 2004 Dec;80(6 Suppl):1735S-9S. Review. Erratum in: Am J Clin Nutr. 2005 Mar;81(3):729.
    PMID: 15585797
Matti Narkia

Vitamin D Deficiency: What a Pain It Is - Mayo Clinic Proceedings - 0 views

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    M. F. Holick
    Vitamin D Deficiency: What a Pain It Is
    Mayo Clin. Proc., December 1, 2003; 78(12): 1457 - 1459.
Matti Narkia

CAM Therapies to Promote Healthy Moods - Pediatr Clin North Am. 2007 Dec - 0 views

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    Complementary and alternative medicine therapies to promote healthy moods.\nKemper KJ, Shannon S.\nPediatr Clin North Am. 2007 Dec;54(6):901-26; x. Review.\nPMID: 18061783 \ndoi: 10.1016/j.pcl.2007.09.002.
Matti Narkia

Vitamin D deficiency an important, common, and easily treatable cardiovascular risk fac... - 0 views

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    Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?\nLee JH, O'Keefe JH, Bell D, Hensrud DD, Holick MF.\nJ Am Coll Cardiol. 2008 Dec 9;52(24):1949-56. Review.\nPMID: 19055985
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