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Matti Narkia

Serum Vitamin D Concentration and Prostate Cancer Risk: A Nested Case-Control Study -- ... - 0 views

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    Serum vitamin D concentration and prostate cancer risk: a nested case-control study.
    Ahn J, Peters U, Albanes D, Purdue MP, Abnet CC, Chatterjee N, Horst RL, Hollis BW, Huang WY, Shikany JM, Hayes RB; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Project Team.
    J Natl Cancer Inst. 2008 Jun 4;100(11):796-804. Epub 2008 May 27.
    PMID: 18505967
    doi:10.1093/jnci/djn152

    CONCLUSION: The findings of this large prospective study do not support the hypothesis that vitamin D is associated with decreased risk of prostate cancer; indeed, higher circulating 25(OH)D concentrations may be associated with increased risk of aggressive disease.

    In summary, results from this large prospective study of men who underwent standardized prostate cancer screening in the context of a screening trial do not support the hypothesis that higher serum vitamin D status is associated with decreased risk of prostate cancer. The study showed no association of vitamin D level with nonaggressive disease; however, it raises the possibility that higher vitamin D level may be associated with increased risks for aggressive disease, although a clear monotonic dose-response relationship was lacking. Along with recent reports of adverse associations for higher vitamin D status and risk of pancreatic (32) and esophageal (33,34) cancer, caution should be taken in recommending high doses of vitamin D or sunlight exposure to the general public for prostate cancer prevention. Future analyses are warranted to confirm these results and to further clarify the effects of vitamin D on aggressive prostate cancer.
Matti Narkia

Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a lo... - 0 views

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    Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study.
    Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, Arden NK, Godfrey KM, Cooper C; Princess Anne Hospital Study Group.
    Lancet. 2006 Jan 7;367(9504):36-43. Erratum in: Lancet. 2006 May 6;367(9521):1486.
    PMID: 16399151
    doi:10.1016/S0140-6736(06)67922-1

    Interpretation
    Maternal vitamin D insufficiency is common during pregnancy and is associated with reduced bone-mineral accrual in the offspring during childhood; this association is mediated partly through the concentration of umbilical venous calcium. Vitamin D supplementation of pregnant women, especially during winter months, could lead to longlasting reductions in the risk of osteoporotic fracture in their offspring.
Matti Narkia

Relationships between 25-Hydroxyvitamin D Levels and Plasma Glucose and Lipid Levels in... - 0 views

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    Relationships between 25-Hydroxyvitamin D Levels and Plasma Glucose and Lipid Levels in Pediatric Outpatients.
    Johnson MD, Nader NS, Weaver AL, Singh R, Kumar S.
    J Pediatr. 2009 Nov 17. [Epub ahead of print]
    PMID: 19926097

    Conclusions
    Low 25(OH) D levels in children and adolescents are associated with higher plasma glucose and lower HDL concentrations.
Matti Narkia

Seasonality of UV-radiation and vitamin D status at 69 degrees north. - Photochem Photo... - 1 views

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    Seasonality of UV-radiation and vitamin D status at 69 degrees north.
    Brustad M, Edvardsen K, Wilsgaard T, Engelsen O, Aksnes L, Lund E.
    Photochem Photobiol Sci. 2007 Aug;6(8):903-8. Epub 2007 Jun 27.
    PMID: 17668121

    The generally high dietary intakes of vitamin D, especially in winter, mask largely the effect of seasonal variation in UV-exposure, causing an atypical seasonal variation in vitamin D status. The UV-hour variable significantly predicted 25(OH)D levels in blood when adjusted for intakes and artificial UV-radiation exposure and sun holidays abroad.
Matti Narkia

The High Prevalence of Vitamin D Insufficiency across Australian Populations Is Only Pa... - 1 views

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    The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude.
    van der Mei IA, Ponsonby AL, Engelsen O, Pasco JA, McGrath JJ, Eyles DW, Blizzard L, Dwyer T, Lucas R, Jones G.
    Environ Health Perspect. 2007 Aug;115(8):1132-9.
    PMID: 17687438
    doi: 10.1289/ehp.9937.

    Conclusion
    Vitamin D insufficiency is common over a wide latitude range in Australia. Season appears to be more important than latitude, but both accounted for less than one-fifth of the variation in serum 25(OH)D levels, highlighting the importance of behavioral factors. Current sun exposure guidelines do not seem to fully prevent vitamin D insufficiency, and consideration should be given to their modification or to pursuing other means to achieve vitamin D adequacy.
Matti Narkia

The solar UV radiation level needed for cutaneous production of vitamin D3 in the face.... - 0 views

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    The solar UV radiation level needed for cutaneous production of vitamin D3 in the face. A study conducted among subjects living at a high latitude (68 degrees N).
    Edvardsen K, Brustad M, Engelsen O, Aksnes L.
    Photochem Photobiol Sci. 2007 Jan;6(1):57-62. Epub 2006 Nov 10.
    PMID: 17200737
Matti Narkia

Duration of vitamin D synthesis from weather model data for use in prospective epidemio... - 0 views

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    Duration of vitamin D synthesis from weather model data for use in prospective epidemiological studies.
    Edvardsen K, Engelsen O, Brustad M.
    Int J Biometeorol. 2009 Sep;53(5):451-9. Epub 2009 May 15.
    PMID: 19444487
Matti Narkia

Vitamin D effective ultraviolet wavelengths due to scattering in shade - ScienceDirect ... - 0 views

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    Vitamin D effective ultraviolet wavelengths due to scattering in shade.
    Turnbull DJ, Parisi AV, Kimlin MG.
    J Steroid Biochem Mol Biol. 2005 Sep;96(5):431-6. Epub 2005 Jul 6.
    PMID: 16005208
Matti Narkia

Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patient... - 0 views

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    Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients.
    Romagnoli E, Caravella P, Scarnecchia L, Martinez P, Minisola S.
    Br J Nutr. 1999 Feb;81(2):133-7.
    PMID: 10450331

    The results of the present study emphasize the importance of 25-hydroxyvitamin D measurement, and the need to increase vitamin D intake in Italy; foodstuff fortification and supplement use must be considered in order to prevent negative effects of vitamin D deficiency on skeletal integrity.

    All hospitalized patients, both in summer and in winter,
    are characterized by the highest prevalence of hypovitaminosis
    D, especially the older patients. Medical
    inpatients may be at risk for vitamin D deficiency,
Matti Narkia

Decreased bioavailability of vitamin D in obesity -- Wortsman et al. 72 (3): 690 -- Ame... - 0 views

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    Decreased bioavailability of vitamin D in obesity.
    Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF.
    Am J Clin Nutr. 2000 Sep;72(3):690-3. Erratum in: Am J Clin Nutr. 2003 May;77(5):1342.
    PMID: 10966885

    Conclusions: Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D3 from cutaneous and dietary sources because of its deposition in body fat compartments.
Matti Narkia

Vitamin D Deficiency in the Morbidly Obese. [Obes Surg. 1993] - PubMed result - 0 views

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    Vitamin D Deficiency in the Morbidly Obese.
    Buffington C, Walker B, Cowan GS Jr, Scruggs D.
    Obes Surg. 1993 Nov;3(4):421-424.
    PMID: 10757956

    These data suggest that low vitamin D may be associated with obesity per se. Hypovitaminosis D, when it is found in post-bariatric surgery patients, may not be caused by the surgery since it may have been present to some degree pre-operatively.
Matti Narkia

Evidence for alteration of the vitamin D-endocrine system in obese subjects. - Journal ... - 0 views

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    Evidence for alteration of the vitamin D-endocrine system in obese subjects.
    Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S.
    J Clin Invest. 1985 Jul;76(1):370-3.
    PMID: 2991340

    The results provide evidence that alteration of the vitamin D-endocrine system in obese subjects is characterized by secondary hyperparathyroidism which is associated with enhanced renal tubular reabsorption of calcium and increased circulating 1,25(OH)2D. The reduction of serum 25-OHD in them is attributed to feedback inhibition of hepatic synthesis of the precursor by the increased serum 1,25(OH)2D.
Matti Narkia

Vitamin D supplementation during the first year of life and risk of schizophrenia: a Fi... - 0 views

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    Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study.
    McGrath J, Saari K, Hakko H, Jokelainen J, Jones P, Järvelin MR, Chant D, Isohanni M.
    Schizophr Res. 2004 Apr 1;67(2-3):237-45.
    PMID: 14984883

    Conclusion: Vitamin D supplementation during the first year of life is associated with a reduced risk of schizophrenia in males. Preventing hypovitaminosis D during early life may reduce the incidence of schizophrenia.
Matti Narkia

Vitamin D3 and 25-hydroxyvitamin D3 in raw and cooked pork cuts - ScienceDirect - Journ... - 0 views

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    Vitamin D3 and 25-hydroxyvitamin D3 in raw and cooked pork cuts.
    Ina Clausen, Jette Jakobsen, Torben Leth and Lars Ovesen.
    Journal of Food Composition and Analysis
    Volume 16, Issue 5, October 2003, Pages 575-585
    doi:10.1016/S0889-1575(03)00064-4

    Meat 25OHD3 contributes significantly to vitamin D activity. Food databases should include concentrations of both vitamin D and 25OHD.
Matti Narkia

Concentrations of vitamin D3 and 25-hydroxyvitamin D3 in raw and cooked New Zealand bee... - 0 views

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    Concentrations of vitamin D3 and 25-hydroxyvitamin D3 in raw and cooked New Zealand beef and lamb.
    Roger Purchas, Maggie Zoua, Philip Pearcea and Felicity Jackson-
    Journal of Food Composition and Analysis
    Volume 20, Issue 2, March 2007, Pages 90-98

    For lamb, the highest levels of vitamin D3 were in the shoulder chop both before and after cooking, while levels were lowest in the rack muscle. Similar cut differences were shown for 25OHD3 concentrations. For beef there were no significant differences between the cuts for vitamin D3, but concentrations of 25OHD3 were lower in the striploin before and after cooking, Vitamin D3 levels tended to be higher in beef cuts than in lamb cuts, but the opposite held for 25OHD3. Concentrations of vitamin D3 were similar to those in other reports, but the 25OHD3 levels were at the high end of reported ranges. With 25OHD3 being more potent than vitamin D3, it is concluded that meat can make a useful contribution of this vitamin to the human diet.
Matti Narkia

Low Vitamin D Status, High Bone Turnover, and Bone Fractures in Centenarians -- Passeri... - 0 views

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    Low vitamin D status, high bone turnover, and bone fractures in centenarians.
    Passeri G, Pini G, Troiano L, Vescovini R, Sansoni P, Passeri M, Gueresi P, Delsignore R, Pedrazzoni M, Franceschi C.
    J Clin Endocrinol Metab. 2003 Nov;88(11):5109-15.
    PMID: 14602735

    We conclude that the extreme decades of life are characterized by a pathophysiological sequence of events linking vitamin D deficiency, low serum calcium, and secondary hyperparathyroidism with an increase in bone resorption and severe osteopenia. These data offer a rationale for the possible prevention of elevated bone turnover, bone loss, and consequently the reduction of osteoporotic fractures and fracture-induced disability in the oldest olds through the supplementation with calcium and vitamin D.
Matti Narkia

Vitamin D supplementation reduces insulin resistance in South Asian women living in New... - 0 views

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    Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial.
    von Hurst PR, Stonehouse W, Coad J.
    Br J Nutr. 2009 Sep 28:1-7. [Epub ahead of print]
    PMID: 19781131

    In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion. Optimal vitamin D concentrations for reducing IR were shown to be 80-119 nmol/l, providing further evidence for an increase in the recommended adequate levels. Registered Trial No. ACTRN12607000642482.
Matti Narkia

Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need... - 0 views

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    Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need More Vitamin D?
    Mansbach JM, Ginde AA, Camargo CA Jr.
    Pediatrics. 2009 Nov;124(5):1404-1410.
    PMID: 19951983

    CONCLUSIONS: On the basis of a nationally representative sample of US children aged 1 to 11 years, millions of children may have suboptimal levels of 25(OH)D, especially non-Hispanic black and Hispanic children. More data in children are needed not only to understand better the health implications of specific serum levels of 25(OH)D but also to determine the appropriate vitamin D supplement requirements for children.
Matti Narkia

Vitamin D and mortality in older men and women. - Clin Endocrinol (Oxf). 2009 Nov;71(5)... - 0 views

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    Vitamin D and mortality in older men and women.
    Pilz S, Dobnig H, Nijpels G, Heine RJ, Stehouwer CD, Snijder MB, van Dam RM, Dekker JM.
    Clin Endocrinol (Oxf). 2009 Nov;71(5):666-72. Epub 2009 Feb 18.
    PMID: 19226272
    DOI: 10.1111/j.1365-2265.2009.03548.x

    Conclusions Low 25(OH)D levels are associated with all-cause mortality and even more pronounced with cardiovascular mortality, but it remains unclear whether vitamin D deficiency is a cause or a consequence of a poor health status. Therefore, intervention studies are warranted to evaluate whether vitamin D supplementation reduces mortality and cardiovascular diseases.
Matti Narkia

Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mort... - 0 views

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    Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women.
    Semba RD, Houston DK, Ferrucci L, Cappola AR, Sun K, Guralnik JM, Fried LP.
    Nutr Res. 2009 Aug;29(8):525-30.
    PMID: 19761886
    doi:10.1016/j.nutres.2009.07.007

    Older community-dwelling women with low 25(OH)D levels are at an increased risk of death.
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