Skip to main content

Home/ Vitamin D/ Group items tagged primates response immune peptide antimicrobial

Rss Feed Group items tagged

Matti Narkia

Exapation of an ancient Alu short interspersed element provides a highly conserved vita... - 0 views


    We demonstrated that the VDRE in the CAMP gene originated from the exaptation of an AluSx SINE in the lineage leading to humans, apes, OWMs and NWMs and remained under purifying selection for the last 55-60 million years. We present convincing evidence of an evolutionarily fixed, Alu-mediated divergence in steroid hormone nuclear receptor gene regulation between humans/primates and other mammals. Evolutionary selection to place the primate CAMP gene under regulation of the vitamin D pathway potentiates the innate immune response and may counter the anti-inflammatory properties of vitamin D.

    Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.
    Gombart AF, Saito T, Koeffler HP.
    BMC Genomics. 2009 Jul 16;10:321.
    PMID: 19607716
Matti Narkia

Key feature of immune system survived in humans, other primates for 60 million years - 0 views

    A new study has concluded that one key part of the immune system, the ability of vitamin D to regulate anti-bactericidal proteins, is so important that is has been conserved through almost 60 million years of evolution and is shared only by primates, including humans - but no other known animal species.
1 - 2 of 2
Showing 20 items per page