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Matti Narkia

Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Res... - 0 views

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    Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004.
    Melamed ML, Muntner P, Michos ED, Uribarri J, Weber C, Sharma J, Raggi P.
    Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1179-85. Epub 2008 Apr 16.
    PMID: 18417640
    doi: 10.1161/ATVBAHA.108.165886

    Conclusions- Low serum 25(OH)D levels are associated with a higher prevalence of PAD. Several mechanisms have been invoked in the literature to support a potential antiatherosclerotic activity of vitamin D. Prospective cohort and mechanistic studies should be designed to confirm this association.

    Vitamin D is an inhibitor of the renin-angiotensin system and has antiinflammatory and anticoagulant properties. Among 4839 NHANES 2001 to 2004 participants, low 25(OH)D levels were associated with a higher prevalence of PAD, after multivariate adjustment. To confirm this association, longitudinal cohort and mechanistic studies are needed.
Matti Narkia

Low Vitamin D Status despite Abundant Sun Exposure -- Binkley et al. 92 (6): 2130 -- Jo... - 0 views

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    Low vitamin D status despite abundant sun exposure.
    Binkley N, Novotny R, Krueger D, Kawahara T, Daida YG, Lensmeyer G, Hollis BW, Drezner MK.
    J Clin Endocrinol Metab. 2007 Jun;92(6):2130-5. Epub 2007 Apr 10.
    PMID: 17426097
    doi:10.1210/jc.2006-2250

    CONCLUSIONS: These data suggest that variable responsiveness to UVB radiation is evident among individuals, causing some to have low vitamin D status despite abundant sun exposure. In addition, because the maximal 25(OH)D concentration produced by natural UV exposure appears to be approximately 60 ng/ml, it seems prudent to use this value as an upper limit when prescribing vitamin D supplementation.
Matti Narkia

Global vitamin D status and determinants of hypovitaminosis D - SpringerLink - Journal... - 0 views

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    Global vitamin D status and determinants of hypovitaminosis D.
    Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J; on behalf of the IOF Committee of Scientific Advisors (CSA) Nutrition Working Group.
    Osteoporos Int. 2009 Jun 19. [Epub ahead of print]
    PMID: 19543765

    CONCLUSION: Reports from across the world indicate that hypovitaminosis D is widespread and is re-emerging as a major health problem globally.
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