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Matti Narkia

Reducing the Burden of Disease Through Adequate Intake of Vitamin D3 by William B. Gran... - 1 views

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    Reducing the Burden of Disease Through Adequate Intake of Vitamin D3.
    A presentation at University of California, San Diego,
    April 9, 2008
    by William B. Grant, Ph.D
Matti Narkia

Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a lo... - 0 views

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    Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study.
    Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, Arden NK, Godfrey KM, Cooper C; Princess Anne Hospital Study Group.
    Lancet. 2006 Jan 7;367(9504):36-43. Erratum in: Lancet. 2006 May 6;367(9521):1486.
    PMID: 16399151
    doi:10.1016/S0140-6736(06)67922-1

    Interpretation
    Maternal vitamin D insufficiency is common during pregnancy and is associated with reduced bone-mineral accrual in the offspring during childhood; this association is mediated partly through the concentration of umbilical venous calcium. Vitamin D supplementation of pregnant women, especially during winter months, could lead to longlasting reductions in the risk of osteoporotic fracture in their offspring.
Matti Narkia

Benefits of Vitamin D Supplementation - Journal of American Physicians and Surgeons Vol... - 1 views

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    Benefits of Vitamin D Supplementation
    Joel M. Kauffman, Ph.D.
    Journal of American Physicians and Surgeons
    Volume 14 Number 2 - Summer 2009

    Clinical trials show that vitamin D supplementation at higher
    levels than previously recommended is beneficial for many
    conditions. It decreases the frequency of falls and fractures, helps
    prevent cardiovascular disease, and reduces symptoms of colds or
    influenza. Benefits are also seen in diabetes mellitus, multiple
    sclerosis, Crohn disease, pain, depression, and possibly autism.
    Sunlight does not cause an overdose of vitamin D production,
    and toxicity from supplementation is rare. Dose recommendations
    are increasing, but appear to be lagging the favorable trial results. A
    number of common drugs deplete vitamin D levels, and others may
    limit its biosynthesis from sunlight.
    People with adequate levels from sun exposure will not benefit
    from supplementation. While dietary intake is helpful,
    supplementation is better able to raise serum 25-hydroxyvitamin D ,
    the major circulating metabolite, to the level now thought adequate,
    30-50 ng/mL.
    Where there is inadequate daily sun exposure, oral doses of
    1,000-2,000 IU/d are now considered routine, with much higher
    doses (up to 50,000 IU) for rapid repletion now considered safe.
Matti Narkia

Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sun... - 0 views

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    Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?
    Pignotti GA, Genaro PS, Pinheiro MM, Szejnfeld VL, Martini LA.
    Eur J Nutr. 2009 Nov 28. [Epub ahead of print]
    PMID: 19946776

    CONCLUSION: The dose given (400 IU/day) was not enough to achieve 25(OH)D concentration, considered optimal for bone health.
Matti Narkia

Vitamin D deficiency is associated with worse cognitive performance and lower bone dens... - 0 views

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    Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans.
    Wilkins CH, Birge SJ, Sheline YI, Morris JC.
    J Natl Med Assoc. 2009 Apr;101(4):349-54.
    PMID: 19397226

    CONCLUSIONS: Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip
Matti Narkia

Effects Of Vitamin D Deficiency Amplified By Shortage Of Estrogen - 0 views

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    "Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.

    In a national study in 1010 men, to be presented Nov. 15 at the American Heart Association's (AHA) annual Scientific Sessions in Orlando, researchers say the new findings build on previous studies showing that deficiencies in vitamin D and low levels of estrogen, found naturally in differing amounts in men and women, were independent risk factors for hardened and narrowed arteries and weakened bones. Vitamin D is an essential part to keeping the body healthy, and can be obtained from fortified foods, such as milk and cereals, and by exposure to sunlight.
Matti Narkia

Low Vitamin D Levels May Raise Heart Risk - 0 views

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    "Study Shows Vitamin D Supplements May Be Useful in Preventing Heart Disease

    Nov. 16, 2009 (Orlando, Fla.) -- Some men with low levels of vitamin D in their blood are at particularly high risk of developing heart disease and weakened bones that can lead to osteoporosis, researchers report.

    In a study of more than 1,000 men, those with low levels of both vitamin D and the sex hormone estrogen were at significantly increased risk of having cardiovascular disease, says study head Erin Michos, MD, a cardiologist at Johns Hopkins.

    "They were also at dramatically increased risk of osteopenia," or bone loss that can lead to osteoporosis, she says.

    "Our results suggest that vitamin D supplements, which are already prescribed to treat osteoporosis, may also be useful in preventing heart disease," Michos tells WebMD.

    Men with low levels of vitamin D and testosterone, on the other hand, were not at heightened risk for heart disease or osteopenia."
Matti Narkia

Effectiveness and safety of vitamin D in relation to bone health. - [Evid Rep Technol A... - 0 views

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    Effectiveness and safety of vitamin D in relation to bone health.
    Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V.
    Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235. Review.
    PMID: 18088161
Matti Narkia

Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies - 0 views

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    Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies
    Viljakainen, Heli Tuulikki
    University of Helsinki
    2008-05-23
    Doctoral dissertation (article-based)

    Vitamin D is required for normal bone growth and maintenance of the skeleton throughout life. In Finland, like in many other Western countries, the population suffers from inadequate or deficient vitamin D status, especially during winter, which is thought to increase the risk of osteoporosis. New strategies to prevent osteoporosis are actively being sought. The main objective of this thesis was to determine whether vitamin D is feasible in the primary prevention of osteoporosis; does it affect bone mineral accrual during the growth period? A second goal was to ascertain whether seasonal variation in calcitropic hormones affects bone remodelling, and to elucidate the vitamin D intake needed to overcome this variation in different age groups.

    In summary, vitamin D intake remains inadequate among the target groups of this thesis, as reflected by seasonal variation in calcitropic hormones and bone metabolism. Dietary intake of vitamin D should be increased to achieve at least an adequate vitamin D status (S-25-OHD>50 nmol/l) and possibly an optimal vitamin D status (S-25-OHD>80 nmol/l) throughout the year. This could be accomplished by introducing new vitamin D-fortified foods to the market."
Matti Narkia

Coeliac bone loss link uncovered - BBC NEWS | Health - 0 views

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    "People with coeliac disease may be more susceptible to osteoporosis because their own immune system attacks their bone tissue, a study suggests.

    Osteoporosis is a known risk of coeliac disease and has been explained by a failure to absorb calcium or vitamin D. "
Matti Narkia

African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox -- Aloia 88 (2): 54... - 0 views

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    African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox.
    Aloia JF.
    Am J Clin Nutr. 2008 Aug;88(2):545S-550S. Review.
    PMID: 18689399
Matti Narkia

Aggressive Vitamin D Treatment for Osteoporosis - 0 views

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    "May 19, 2008 (Orlando, Florida) - A new study shows that a proactive vitamin D treatment plan should be considered when caring for all osteoporosis patients, and that such treatment might help decrease the likelihood of developing vitamin D deficiency.

    Vitamin D deficiency is widespread among patients being treated for osteoporosis, and such deficiency should be treated aggressively, according to the findings presented here at the American Association of Clinical Endocrinologists 17th Annual Meeting and Clinical Congress."
Matti Narkia

Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elder... - 0 views

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    Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women.
    Dawson-Hughes B, Harris SS, Dallal GE.
    Am J Clin Nutr. 1997 Jan;65(1):67-71.
    PMID: 8988915

    Plasma calcidiol and serum PTH concentrations were inversely related, with PTH rising slowly as calcidiol concentrations declined below 110 nmol/L (95 CI: 60, 168 nmol/L). More than 90% of the men and women had calcidiol concentrations below this value in the wintertime. The high prevalence of lower wintertime calcidiol values may increase risk of bone loss in elderly men and women.
Matti Narkia

Vitamin D and vitamin D analogues for preventing fractures associated with involutional... - 0 views

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    Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis.
    Avenell A, Gillespie WJ, Gillespie LD, O'Connell D.
    Cochrane Database Syst Rev. 2009 Apr 15;(2):CD000227. Review.
    PMID: 19370554
    DOI: 10.1002/14651858.CD000227.pub3

    AUTHORS' CONCLUSIONS: Frail older people confined to institutions may sustain fewer hip fractures if given vitamin D with calcium. Vitamin D alone is unlikely to prevent fracture. Overall there is a small but significant increase in gastrointestinal symptoms and renal disease associated with vitamin D or its analogues. Calcitriol is associated with an increased incidence of hypercalcaemia.
Matti Narkia

Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset... - 0 views

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    Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density.
    Abreu MT, Kantorovich V, Vasiliauskas EA, Gruntmanis U, Matuk R, Daigle K, Chen S, Zehnder D, Lin YC, Yang H, Hewison M, Adams JS.
    Gut. 2004 Aug;53(8):1129-36.
    PMID: 15247180
    doi: 10.1136/gut.2003.036657.

    Conclusions: These data demonstrate that elevated 1,25(OH)2D is more common in CD than previously appreciated and is independently associated with low bone mineral density. The source of the active vitamin D may be the inflamed intestine. Treatment of the underlying inflammation may improve metabolic bone disease in this subgroup of patients.
Matti Narkia

Vitamin D status affects serum parathyroid hormone concentrations during winter in fema... - 0 views

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    Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density.
    Outila TA, Kärkkäinen MU, Lamberg-Allardt CJ.
    Am J Clin Nutr. 2001 Aug;74(2):206-10.
    PMID: 11470722

    Conclusion: A large percentage of adolescent females have low vitamin D status during the winter in Finland, which seems to have negative effects on bone health.
Matti Narkia

NEJM -- Vitamin D3 and calcium to prevent hip fractures in the elderly women - 0 views

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    Vitamin D3 and calcium to prevent hip fractures in the elderly women.
    Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ.
    N Engl J Med. 1992 Dec 3;327(23):1637-42.
    PMID: 1331788

    CONCLUSIONS. Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.
Matti Narkia

Vitamin D deficiency and bone health in healthy adults in Finland: could this be a conc... - 0 views

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    Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe?
    Lamberg-Allardt CJ, Outila TA, Kärkkainen MU, Rita HJ, Valsta LM.
    J Bone Miner Res. 2001 Nov;16(11):2066-73.
    PMID: 11697803

    Low vitamin D status was prevalent in these young adults in northern Europe in winter, although the vitamin D intake met the recommendation. This probably is not a local problem for northern Europe, because the natural sources of vitamin D are scarce and fortification is not very common in Europe, and with the exception of the southern part of Europe, sunshine is not very abundant in this part of the world. Thus, the results of this study indicate that more attention should be focused on vitamin D status and the sources of vitamin D in these countries.
Matti Narkia

Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual a... - 0 views

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    Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial.
    Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A, Nicholson PH, Ivaska KK, Korpela R, Ohlsson C, Väänänen KH, Tylavsky F.
    Am J Clin Nutr. 2005 Nov;82(5):1115-26; quiz 1147-8.
    PMID: 16280447
Matti Narkia

Reducing fracture risk with calcium and vitamin D. - Wiley InterScience :: JO... - 0 views

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    Reducing fracture risk with calcium and vitamin D.
    Lips P, Bouillon R, van Schoor NM, Vanderschueren D, Verschueren S, Kuchuk N, Milisen K, Boonen S.
    Clin Endocrinol (Oxf). 2009 Sep 10. [Epub ahead of print]
    PMID: 19744099
    DOI: 10.1111/j.0300-0664.2009.03701.x
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