Skip to main content

Home/ Vitamin D/ Group items tagged nutrition humans VDRE

Rss Feed Group items tagged

Matti Narkia

Exapation of an ancient Alu short interspersed element provides a highly conserved vita... - 0 views

  •  
    Conclusion

    We demonstrated that the VDRE in the CAMP gene originated from the exaptation of an AluSx SINE in the lineage leading to humans, apes, OWMs and NWMs and remained under purifying selection for the last 55-60 million years. We present convincing evidence of an evolutionarily fixed, Alu-mediated divergence in steroid hormone nuclear receptor gene regulation between humans/primates and other mammals. Evolutionary selection to place the primate CAMP gene under regulation of the vitamin D pathway potentiates the innate immune response and may counter the anti-inflammatory properties of vitamin D.

    Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.
    Gombart AF, Saito T, Koeffler HP.
    BMC Genomics. 2009 Jul 16;10:321.
    PMID: 19607716
    doi:10.1186/1471-2164-10-321
Matti Narkia

Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is re... - 0 views

  •  
    Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D.\nRamagopalan SV, Maugeri NJ, Handunnetthi L, Lincoln MR, Orton SM, Dyment DA, Deluca GC, Herrera BM, Chao MJ, Sadovnick AD, Ebers GC, Knight JC.\nPLoS Genet. 2009 Feb;5(2):e1000369. Epub 2009 Feb 6.\nPMID: 19197344 [
1 - 2 of 2
Showing 20 items per page