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Matti Narkia

A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in brea... - 0 views

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    A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in breast cancer patients with bone metastases.
    Amir E, Simmons CE, Freedman OC, Dranitsaris G, Cole DE, Vieth R, Ooi WS, Clemons M.
    Cancer. 2009 Nov 13. [Epub ahead of print]
    PMID: 19918922
    DOI: 10.1002/cncr.24749

    METHODS:
    Patients with bone metastases treated with bisphosphonates were enrolled into this single-arm phase 2 study. Patients received 10,000 IU of vitamin D3 and 1000 mg of calcium supplementation each day for 4 months. The effect of this treatment on palliation, bone resorption markers, calcium metabolism, and toxicity were evaluated at baseline and monthly thereafter.


    CONCLUSIONS:
    Daily doses of 10,000 IU vitamin D3 for 4 months appear safe in patients without comorbid conditions causing hypersensitivity to vitamin D. Treatment reduced inappropriately elevated parathyroid hormone levels, presumably caused by long-term bisphosphonate use. There did not appear to be a significant palliative benefit nor any significant change in bone resorption. Cancer 2010. © 2009 American Cancer Society.
Matti Narkia

Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer ... - 0 views

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    Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men.
    Tang JY, Parimi N, Wu A, John Boscardin W, Shikany JM, Chren MM, Cummings SR, Epstein EH Jr, Bauer DC; for the Osteoporotic Fractures in Men (MrOS) Study Group.
    Cancer Causes Control. 2009 Nov 18. [Epub ahead of print]
    PMID: 19921445

    Our results suggest that a diagnosis of NMSC is not a surrogate for adequate 25(OH)D levels or increased UV exposure, and high 25(OH)D levels may be associated with a reduced risk of NMSC.
Matti Narkia

Vitamin D association with estradiol and progesterone in young women. - [Cancer Causes ... - 0 views

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    Vitamin D association with estradiol and progesterone in young women.
    Knight JA, Wong J, Blackmore KM, Raboud JM, Vieth R.
    Cancer Causes Control. 2009 Nov 15. [Epub ahead of print]
    PMID: 19916051

    CONCLUSIONS: Higher levels of vitamin D may reduce progesterone and estradiol, providing a potential mechanism for reduction in breast cancer risk from increased vitamin D exposure in young women.
Matti Narkia

Calcium Plus Vitamin D Supplementation and the Risk of Breast Cancer -- Chlebowski et a... - 0 views

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    Calcium plus vitamin D supplementation and the risk of breast cancer.
    Chlebowski RT, Johnson KC, Kooperberg C, Pettinger M, Wactawski-Wende J, Rohan T, Rossouw J, Lane D, O'Sullivan MJ, Yasmeen S, Hiatt RA, Shikany JM, Vitolins M, Khandekar J, Hubbell FA; Women's Health Initiative Investigators.
    J Natl Cancer Inst. 2008 Nov 19;100(22):1581-91. Epub 2008 Nov 11.
    PMID: 19001601
Matti Narkia

Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. - [Lancet. 19... - 0 views

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    Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study.
    Garland CF, Comstock GW, Garland FC, Helsing KJ, Shaw EK, Gorham ED.
    Lancet. 1989 Nov 18;2(8673):1176-8.
    PMID: 2572900

    Blood samples taken in 1974 in Washington County, Maryland, from 25 620 volunteers were used to investigate the relation of serum 25-hydroxyvitamin D (25-OHD) with subsequent risk of getting colon cancer. 34 cases of colon cancer diagnosed between August, 1975, and January, 1983, were matched to 67 controls by age, race, sex, and month blood was taken. Risk of colon cancer was reduced by 75% in the third quintile (27-32 ng/ml) and by 80% in the fourth quintile (33-41 ng/ml) of serum 25-OHD. Risk of getting colon cancer decreased three-fold in people with a serum 25-OHD concentration of 20 ng/ml or more. The results are consistent with a protective effect of serum 25-OHD on colon cancer.
Matti Narkia

Are sunlight deprivation and influenza epidemics associated with the onset of acute leu... - 0 views

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    Are sunlight deprivation and influenza epidemics associated with the onset of acute leukemia?
    Timonen T, Näyhä S, Koskela T, Pukkala E.
    Haematologica. 2007 Nov;92(11):1553-6.
    PMID: 18024404
    doi:10.3324/haematol.10799

    Month of diagnosis of 7,423 cases of acute leukemia (AL) in Finland during 1964-2003 were linked with data on influenza and solar radiation. Acute myeloblastic leukemia (AML) showed the highest risk in the dark season. During the light season, the incidence decreased by 58% (95% confidence interval, 16-79%) per 1,000 kJ/m2/d increase of solar radiation. Independent of solar radiation, AML increased by 9% (95% confidence interval, 0-19%) during influenza epidemics. Reoccurring at the same time annually, darkness-related vitamin D deficiency and influenza could cause successive and co-operative mutations leading to AL with a short latency.
Matti Narkia

Vitamin D Status and the Risk of Lung Cancer: A Cohort Study in Finland - Cancer Epidem... - 0 views

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    Vitamin D status and the risk of lung cancer: a cohort study in Finland.
    Kilkkinen A, Knekt P, Heliövaara M, Rissanen H, Marniemi J, Hakulinen T, Aromaa A.
    Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3274-8.
    PMID: 18990771v

    In conclusion, although there was no overall association between vitamin D and lung cancer risk, women and young participants with a higher level of vitamin D were observed to have a lower lung cancer risk. Although experimental data support the suppressing effect of vitamin D on the development of lung cancer, large epidemiologic studies from different populations with repeated measurements of vitamin D are warranted to confirm this finding. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3274-8)
Matti Narkia

Geographic variation in breast cancer mortality in the United States: A hypothesis invo... - 0 views

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    Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation.
    Garland FC, Garland CF, Gorham ED, Young JF.
    Prev Med. 1990 Nov;19(6):614-22.
    PMID: 2263572
    doi:10.1016/0091-7435(90)90058-R

    Vitamin D from sunlight exposure may be associated with low risk for fatal breast cancer, and differences in ultraviolet light reaching the United States population may account for the striking regional differences in breast cancer mortality. The ecological nature of this study is emphasized, and the possibility that an indirect association with dietary and socioeconomic factors could explain these findings is discussed.
Matti Narkia

Vitamin D may help treat prostate cancer - 0 views

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    The Toronto group gave a fixed low dose (2,000 units) of the prehormone, cholecalciferol, a very safe compound that never causes high calcium in the doses used. In fact, the lowest dose of cholecalciferol known to cause high blood calcium is more than 20,000 units. Therefore, the Toronto group got better results with one-tenth the comparable dose of deltanoids! Vieth wanted to use more cholecalciferol but widespread ignorance about the physiology and pharmacology of vitamin D remains and he could not get adequate dosing past the various review committees.
Matti Narkia

Vitamin D and prevention of colorectal adenoma: a meta-analysis - Cancer Epidemiol Bio... - 0 views

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    Vitamin D and prevention of colorectal adenoma: a meta-analysis.\nWei MY, Garland CF, Gorham ED, Mohr SB, Giovannucci E.\nCancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):2958-69.\nPMID: 18990737
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